F3 (coagulation factor III, tissue factor)

2003-08-01  

Identity

HGNC
LOCATION
1p21.3
LOCUSID
ALIAS
CD142,TF,TFA
FUSION GENES

Other Information

Locus ID:

NCBI: 2152
MIM: 134390
HGNC: 3541
Ensembl: ENSG00000117525

Variants:

dbSNP: 2152
ClinVar: 2152
TCGA: ENSG00000117525
COSMIC: F3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117525ENST00000334047P13726
ENSG00000117525ENST00000370207P13726

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Extrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140834
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446459Myocardial IschemiaDiseaseClinicalAnnotationassociatedPD19027114
PA451363simvastatinChemicalClinicalAnnotationassociatedPD19027114

References

Pubmed IDYearTitleCitations
154944272005Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.151
151177362004Role of tissue factor in hemostasis, thrombosis, and vascular development.144
169598862006Disulfide isomerization switches tissue factor from coagulation to cell signaling.121
198286972010Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation.121
198614412009Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy.117
170604762006Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets.110
179012452008Inhibition of tissue factor signaling suppresses tumor growth.107
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
164889802006Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor.83
120700202002Thrombin functions during tissue factor-induced blood coagulation.79

Citation

Dessen P

F3 (coagulation factor III, tissue factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40522/f3