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F3 (coagulation factor III, tissue factor)

Identity

Alias_namescoagulation factor III (thromboplastin
Alias_symbol (synonym)CD142
TF
Other aliasTFA
HGNC (Hugo) F3
LocusID (NCBI) 2152
Atlas_Id 40522
Location 1p21.3  [Link to chromosome band 1p21]
Location_base_pair Starts at 94529176 and ends at 94541857 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGAP1 (2q37.2) / F3 (1p21.3)F3 (1p21.3) / C11orf80 (11q13.2)F3 (1p21.3) / C1orf21 (1q25.3)
F3 (1p21.3) / SPG7 (16q24.3)F3 (1p21.3) / SQSTM1 (5q35.3)F3 (1p21.3) / TMTC2 (12q21.31)
LBH (2p23.1) / F3 (1p21.3)RBM3 (Xp11.23) / F3 (1p21.3)SETD2 (3p21.31) / F3 (1p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)F3   3541
Cards
Entrez_Gene (NCBI)F3  2152  coagulation factor III, tissue factor
AliasesCD142; TF; TFA
GeneCards (Weizmann)F3
Ensembl hg19 (Hinxton)ENSG00000117525 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117525 [Gene_View]  chr1:94529176-94541857 [Contig_View]  F3 [Vega]
ICGC DataPortalENSG00000117525
TCGA cBioPortalF3
AceView (NCBI)F3
Genatlas (Paris)F3
WikiGenes2152
SOURCE (Princeton)F3
Genetics Home Reference (NIH)F3
Genomic and cartography
GoldenPath hg38 (UCSC)F3  -     chr1:94529176-94541857 -  1p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)F3  -     1p21.3   [Description]    (hg19-Feb_2009)
EnsemblF3 - 1p21.3 [CytoView hg19]  F3 - 1p21.3 [CytoView hg38]
Mapping of homologs : NCBIF3 [Mapview hg19]  F3 [Mapview hg38]
OMIM134390   
Gene and transcription
Genbank (Entrez)AF487337 AF497569 AF497570 AF497571 AK310918
RefSeq transcript (Entrez)NM_001178096 NM_001993
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)F3
Cluster EST : UnigeneHs.62192 [ NCBI ]
CGAP (NCI)Hs.62192
Alternative Splicing GalleryENSG00000117525
Gene ExpressionF3 [ NCBI-GEO ]   F3 [ EBI - ARRAY_EXPRESS ]   F3 [ SEEK ]   F3 [ MEM ]
Gene Expression Viewer (FireBrowse)F3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2152
GTEX Portal (Tissue expression)F3
Human Protein AtlasENSG00000117525-F3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13726   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13726  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13726
Splice isoforms : SwissVarP13726
PhosPhoSitePlusP13726
Domaine pattern : Prosite (Expaxy)TISSUE_FACTOR (PS00621)   
Domains : Interpro (EBI)FN3_dom    Ig-like_fold    Interferon/interleukin_rcp_dom    Tissue_fac/coagulation_fac-3    Tissue_factor    Tissue_Factor_CS   
Domain families : Pfam (Sanger)Interfer-bind (PF09294)    Tissue_fac (PF01108)   
Domain families : Pfam (NCBI)pfam09294    pfam01108   
Conserved Domain (NCBI)F3
DMDM Disease mutations2152
Blocks (Seattle)F3
PDB (SRS)1AHW    1BOY    1DAN    1FAK    1J9C    1JPS    1NL8    1O5D    1TFH    1UJ3    1W0Y    1W2K    1WQV    1WSS    1WTG    1WUN    1WV7    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2C4F    2CEF    2CEH    2CEZ    2CFJ    2EC9    2F9B    2FIR    2FLB    2FLR    2HFT    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4M7L    4YLQ    4Z6A    4ZMA   
PDB (PDBSum)1AHW    1BOY    1DAN    1FAK    1J9C    1JPS    1NL8    1O5D    1TFH    1UJ3    1W0Y    1W2K    1WQV    1WSS    1WTG    1WUN    1WV7    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2C4F    2CEF    2CEH    2CEZ    2CFJ    2EC9    2F9B    2FIR    2FLB    2FLR    2HFT    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4M7L    4YLQ    4Z6A    4ZMA   
PDB (IMB)1AHW    1BOY    1DAN    1FAK    1J9C    1JPS    1NL8    1O5D    1TFH    1UJ3    1W0Y    1W2K    1WQV    1WSS    1WTG    1WUN    1WV7    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2C4F    2CEF    2CEH    2CEZ    2CFJ    2EC9    2F9B    2FIR    2FLB    2FLR    2HFT    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4M7L    4YLQ    4Z6A    4ZMA   
PDB (RSDB)1AHW    1BOY    1DAN    1FAK    1J9C    1JPS    1NL8    1O5D    1TFH    1UJ3    1W0Y    1W2K    1WQV    1WSS    1WTG    1WUN    1WV7    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2C4F    2CEF    2CEH    2CEZ    2CFJ    2EC9    2F9B    2FIR    2FLB    2FLR    2HFT    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4M7L    4YLQ    4Z6A    4ZMA   
Structural Biology KnowledgeBase1AHW    1BOY    1DAN    1FAK    1J9C    1JPS    1NL8    1O5D    1TFH    1UJ3    1W0Y    1W2K    1WQV    1WSS    1WTG    1WUN    1WV7    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2C4F    2CEF    2CEH    2CEZ    2CFJ    2EC9    2F9B    2FIR    2FLB    2FLR    2HFT    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4M7L    4YLQ    4Z6A    4ZMA   
SCOP (Structural Classification of Proteins)1AHW    1BOY    1DAN    1FAK    1J9C    1JPS    1NL8    1O5D    1TFH    1UJ3    1W0Y    1W2K    1WQV    1WSS    1WTG    1WUN    1WV7    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2C4F    2CEF    2CEH    2CEZ    2CFJ    2EC9    2F9B    2FIR    2FLB    2FLR    2HFT    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4M7L    4YLQ    4Z6A    4ZMA   
CATH (Classification of proteins structures)1AHW    1BOY    1DAN    1FAK    1J9C    1JPS    1NL8    1O5D    1TFH    1UJ3    1W0Y    1W2K    1WQV    1WSS    1WTG    1WUN    1WV7    1Z6J    2A2Q    2AEI    2AER    2B7D    2B8O    2C4F    2CEF    2CEH    2CEZ    2CFJ    2EC9    2F9B    2FIR    2FLB    2FLR    2HFT    2PUQ    2ZP0    2ZWL    2ZZU    3ELA    3TH2    3TH3    3TH4    4IBL    4M7L    4YLQ    4Z6A    4ZMA   
SuperfamilyP13726
Human Protein Atlas [tissue]ENSG00000117525-F3 [tissue]
Peptide AtlasP13726
HPRD00603
IPIIPI00010338   IPI00384454   
Protein Interaction databases
DIP (DOE-UCLA)P13726
IntAct (EBI)P13726
FunCoupENSG00000117525
BioGRIDF3
STRING (EMBL)F3
ZODIACF3
Ontologies - Pathways
QuickGOP13726
Ontology : AmiGOpositive regulation of endothelial cell proliferation  protease binding  activation of plasma proteins involved in acute inflammatory response  activation of blood coagulation via clotting cascade  serine-type endopeptidase activity  cytokine receptor activity  protein binding  phospholipid binding  extracellular space  plasma membrane  plasma membrane  activation of cysteine-type endopeptidase activity involved in apoptotic process  blood coagulation  blood coagulation, extrinsic pathway  cell surface  positive regulation of platelet-derived growth factor receptor signaling pathway  integral component of membrane  protein processing  cytokine-mediated signaling pathway  positive regulation of cell migration  extracellular matrix  intrinsic component of external side of plasma membrane  positive regulation of angiogenesis  positive regulation of positive chemotaxis  positive regulation of protein kinase B signaling  extracellular exosome  serine-type peptidase complex  
Ontology : EGO-EBIpositive regulation of endothelial cell proliferation  protease binding  activation of plasma proteins involved in acute inflammatory response  activation of blood coagulation via clotting cascade  serine-type endopeptidase activity  cytokine receptor activity  protein binding  phospholipid binding  extracellular space  plasma membrane  plasma membrane  activation of cysteine-type endopeptidase activity involved in apoptotic process  blood coagulation  blood coagulation, extrinsic pathway  cell surface  positive regulation of platelet-derived growth factor receptor signaling pathway  integral component of membrane  protein processing  cytokine-mediated signaling pathway  positive regulation of cell migration  extracellular matrix  intrinsic component of external side of plasma membrane  positive regulation of angiogenesis  positive regulation of positive chemotaxis  positive regulation of protein kinase B signaling  extracellular exosome  serine-type peptidase complex  
Pathways : BIOCARTAExtrinsic Prothrombin Activation Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkF3
Atlas of Cancer Signalling NetworkF3
Wikipedia pathwaysF3
Orthology - Evolution
OrthoDB2152
GeneTree (enSembl)ENSG00000117525
Phylogenetic Trees/Animal Genes : TreeFamF3
HOVERGENP13726
HOGENOMP13726
Homologs : HomoloGeneF3
Homology/Alignments : Family Browser (UCSC)F3
Gene fusions - Rearrangements
Tumor Fusion PortalF3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)F3
dbVarF3
ClinVarF3
1000_GenomesF3 
Exome Variant ServerF3
ExAC (Exome Aggregation Consortium)ENSG00000117525
GNOMAD BrowserENSG00000117525
Genetic variants : HAPMAP2152
Genomic Variants (DGV)F3 [DGVbeta]
DECIPHERF3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisF3 
Mutations
ICGC Data PortalF3 
TCGA Data PortalF3 
Broad Tumor PortalF3
OASIS PortalF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICF3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDF3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch F3
DgiDB (Drug Gene Interaction Database)F3
DoCM (Curated mutations)F3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)F3 (select a term)
intoGenF3
Cancer3DF3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134390   
Orphanet
DisGeNETF3
MedgenF3
Genetic Testing Registry F3
NextProtP13726 [Medical]
TSGene2152
GENETestsF3
Target ValidationF3
Huge Navigator F3 [HugePedia]
snp3D : Map Gene to Disease2152
BioCentury BCIQF3
ClinGenF3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2152
Chemical/Pharm GKB GenePA158
Clinical trialF3
Miscellaneous
canSAR (ICR)F3 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineF3
EVEXF3
GoPubMedF3
iHOPF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:12:33 CET 2017

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