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FAT4 (FAT atypical cadherin 4)

Identity

Alias_namesFAT tumor suppressor homolog 4 (Drosophila)
Alias_symbol (synonym)CDHF14
FAT-J
CDHR11
Other aliasFATJ
HKLLS2
NBLA00548
VMLDS2
HGNC (Hugo) FAT4
LocusID (NCBI) 79633
Atlas_Id 40537
Location 4q28.1  [Link to chromosome band 4q28]
Location_base_pair Starts at 125316412 and ends at 125492932 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAT4 (4q28.1) / STAMBPL1 (10q23.31)UBA1 (Xp11.23) / FAT4 (4q28.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FAT4   23109
Cards
Entrez_Gene (NCBI)FAT4  79633  FAT atypical cadherin 4
AliasesCDHF14; CDHR11; FAT-J; FATJ; 
HKLLS2; NBLA00548; VMLDS2
GeneCards (Weizmann)FAT4
Ensembl hg19 (Hinxton)ENSG00000196159 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196159 [Gene_View]  chr4:125316412-125492932 [Contig_View]  FAT4 [Vega]
ICGC DataPortalENSG00000196159
TCGA cBioPortalFAT4
AceView (NCBI)FAT4
Genatlas (Paris)FAT4
WikiGenes79633
SOURCE (Princeton)FAT4
Genetics Home Reference (NIH)FAT4
Genomic and cartography
GoldenPath hg38 (UCSC)FAT4  -     chr4:125316412-125492932 +  4q28.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAT4  -     4q28.1   [Description]    (hg19-Feb_2009)
EnsemblFAT4 - 4q28.1 [CytoView hg19]  FAT4 - 4q28.1 [CytoView hg38]
Mapping of homologs : NCBIFAT4 [Mapview hg19]  FAT4 [Mapview hg38]
OMIM612411   615546   616006   
Gene and transcription
Genbank (Entrez)AB075518 AK026709 AK091292 AK096646 AK291461
RefSeq transcript (Entrez)NM_001291285 NM_001291303 NM_024582
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FAT4
Cluster EST : UnigeneHs.563205 [ NCBI ]
CGAP (NCI)Hs.563205
Alternative Splicing GalleryENSG00000196159
Gene ExpressionFAT4 [ NCBI-GEO ]   FAT4 [ EBI - ARRAY_EXPRESS ]   FAT4 [ SEEK ]   FAT4 [ MEM ]
Gene Expression Viewer (FireBrowse)FAT4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79633
GTEX Portal (Tissue expression)FAT4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6V0I7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6V0I7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6V0I7
Splice isoforms : SwissVarQ6V0I7
PhosPhoSitePlusQ6V0I7
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    CADHERIN_1 (PS00232)    CADHERIN_2 (PS50268)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)Cadherin    Cadherin-like    Cadherin_CS    ConA-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_    Laminin_G   
Domain families : Pfam (Sanger)Cadherin (PF00028)    EGF_CA (PF07645)    hEGF (PF12661)    Laminin_G_2 (PF02210)   
Domain families : Pfam (NCBI)pfam00028    pfam07645    pfam12661    pfam02210   
Domain families : Smart (EMBL)CA (SM00112)  EGF (SM00181)  EGF_CA (SM00179)  LamG (SM00282)  
Conserved Domain (NCBI)FAT4
DMDM Disease mutations79633
Blocks (Seattle)FAT4
SuperfamilyQ6V0I7
Human Protein AtlasENSG00000196159
Peptide AtlasQ6V0I7
HPRD07637
IPIIPI00852735   IPI00419327   IPI00888207   
Protein Interaction databases
DIP (DOE-UCLA)Q6V0I7
IntAct (EBI)Q6V0I7
FunCoupENSG00000196159
BioGRIDFAT4
STRING (EMBL)FAT4
ZODIACFAT4
Ontologies - Pathways
QuickGOQ6V0I7
Ontology : AmiGObranching involved in ureteric bud morphogenesis  heart morphogenesis  calcium ion binding  protein binding  intracellular  plasma membrane  plasma membrane organization  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  Notch signaling pathway  fibroblast growth factor receptor signaling pathway  integral component of membrane  cerebral cortex development  neurogenesis  hippo signaling  ossification involved in bone maturation  apical part of cell  digestive tract development  inner ear receptor stereocilium organization  extracellular exosome  condensed mesenchymal cell proliferation  regulation of metanephric nephron tubule epithelial cell differentiation  
Ontology : EGO-EBIbranching involved in ureteric bud morphogenesis  heart morphogenesis  calcium ion binding  protein binding  intracellular  plasma membrane  plasma membrane organization  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  Notch signaling pathway  fibroblast growth factor receptor signaling pathway  integral component of membrane  cerebral cortex development  neurogenesis  hippo signaling  ossification involved in bone maturation  apical part of cell  digestive tract development  inner ear receptor stereocilium organization  extracellular exosome  condensed mesenchymal cell proliferation  regulation of metanephric nephron tubule epithelial cell differentiation  
NDEx NetworkFAT4
Atlas of Cancer Signalling NetworkFAT4
Wikipedia pathwaysFAT4
Orthology - Evolution
OrthoDB79633
GeneTree (enSembl)ENSG00000196159
Phylogenetic Trees/Animal Genes : TreeFamFAT4
HOVERGENQ6V0I7
HOGENOMQ6V0I7
Homologs : HomoloGeneFAT4
Homology/Alignments : Family Browser (UCSC)FAT4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAT4
dbVarFAT4
ClinVarFAT4
1000_GenomesFAT4 
Exome Variant ServerFAT4
ExAC (Exome Aggregation Consortium)FAT4 (select the gene name)
Genetic variants : HAPMAP79633
Genomic Variants (DGV)FAT4 [DGVbeta]
DECIPHERFAT4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAT4 
Mutations
ICGC Data PortalFAT4 
TCGA Data PortalFAT4 
Broad Tumor PortalFAT4
OASIS PortalFAT4 [ Somatic mutations - Copy number]
Cancer Gene: CensusFAT4 
Somatic Mutations in Cancer : COSMICFAT4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFAT4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FAT4
DgiDB (Drug Gene Interaction Database)FAT4
DoCM (Curated mutations)FAT4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FAT4 (select a term)
intoGenFAT4
Cancer3DFAT4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612411    615546    616006   
Orphanet2036    21513   
MedgenFAT4
Genetic Testing Registry FAT4
NextProtQ6V0I7 [Medical]
TSGene79633
GENETestsFAT4
Target ValidationFAT4
Huge Navigator FAT4 [HugePedia]
snp3D : Map Gene to Disease79633
BioCentury BCIQFAT4
ClinGenFAT4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79633
Chemical/Pharm GKB GenePA134954366
Clinical trialFAT4
Miscellaneous
canSAR (ICR)FAT4 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFAT4
EVEXFAT4
GoPubMedFAT4
iHOPFAT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:00:58 CEST 2017

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