FBXO8 (F-box protein 8)

2006-10-01  

Identity

HGNC
LOCATION
4q34.1
LOCUSID
ALIAS
DC10,FBS,FBX8

Other Information

Locus ID:

NCBI: 26269
MIM: 605649
HGNC: 13587
Ensembl: ENSG00000164117

Variants:

dbSNP: 26269
ClinVar: 26269
TCGA: ENSG00000164117
COSMIC: FBXO8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164117ENST00000393674Q9NRD0
ENSG00000164117ENST00000393674A0A0S2Z5D1
ENSG00000164117ENST00000503293Q9NRD0
ENSG00000164117ENST00000513696D6RIC0
ENSG00000164117ENST00000515664D6RJ92
ENSG00000164117ENST00000615392Q9NRD0

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
189876182009Screening for replication of genome-wide SNP associations in sporadic ALS.14
208482312010c-Myc stimulates cell invasion by inhibiting FBX8 function.9
279166062017FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma.8
238260802013FBX8 Acts as an Invasion and Metastasis Suppressor and Correlates with Poor Survival in Hepatocellular Carcinoma.5
310240082019FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progression.2
255508532014Down-expression of F box only protein 8 correlates with tumor grade and poor prognosis in human glioma.1
258013342015Significance of FBX8 in progression of gastric cancer.1

Citation

Dessen P

FBXO8 (F-box protein 8)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43256/fbxo8