Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FBXW2 (F-box and WD repeat domain containing 2)

Identity

Alias_namesF-box and WD-40 domain protein 2
Alias_symbol (synonym)FBW2
Md6
Fwd2
Other alias
HGNC (Hugo) FBXW2
LocusID (NCBI) 26190
Atlas_Id 47148
Location 9q33.2  [Link to chromosome band 9q33]
Location_base_pair Starts at 123519254 and ends at 123555740 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGAP10 (4q31.23) / FBXW2 (9q33.2)CSH1 (17q23.3) / FBXW2 (9q33.2)FBXW2 (9q33.2) / ALDOA (16p11.2)
FBXW2 (9q33.2) / C1R (12p13.31)FBXW2 (9q33.2) / FBXW2 (9q33.2)FBXW2 (9q33.2) / HDGF (1q23.1)
ARHGAP10 4q31.23 / FBXW2 9q33.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXW2   13608
Cards
Entrez_Gene (NCBI)FBXW2  26190  F-box and WD repeat domain containing 2
AliasesFBW2; Fwd2; Md6
GeneCards (Weizmann)FBXW2
Ensembl hg19 (Hinxton)ENSG00000119402 [Gene_View]  chr9:123519254-123555740 [Contig_View]  FBXW2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000119402 [Gene_View]  chr9:123519254-123555740 [Contig_View]  FBXW2 [Vega]
ICGC DataPortalENSG00000119402
TCGA cBioPortalFBXW2
AceView (NCBI)FBXW2
Genatlas (Paris)FBXW2
WikiGenes26190
SOURCE (Princeton)FBXW2
Genetics Home Reference (NIH)FBXW2
Genomic and cartography
GoldenPath hg19 (UCSC)FBXW2  -     chr9:123519254-123555740 -  9q33.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FBXW2  -     9q33.2   [Description]    (hg38-Dec_2013)
EnsemblFBXW2 - 9q33.2 [CytoView hg19]  FBXW2 - 9q33.2 [CytoView hg38]
Mapping of homologs : NCBIFBXW2 [Mapview hg19]  FBXW2 [Mapview hg38]
OMIM609071   
Gene and transcription
Genbank (Entrez)AF129531 AF145024 AF176698 AF193594 AK022484
RefSeq transcript (Entrez)NM_012164
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)FBXW2
Cluster EST : UnigeneHs.494985 [ NCBI ]
CGAP (NCI)Hs.494985
Alternative Splicing GalleryENSG00000119402
Gene ExpressionFBXW2 [ NCBI-GEO ]   FBXW2 [ EBI - ARRAY_EXPRESS ]   FBXW2 [ SEEK ]   FBXW2 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXW2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26190
GTEX Portal (Tissue expression)FBXW2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKT8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKT8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKT8
Splice isoforms : SwissVarQ9UKT8
PhosPhoSitePlusQ9UKT8
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)F-box_dom    G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)F-box-like (PF12937)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12937    pfam00400   
Domain families : Smart (EMBL)FBOX (SM00256)  WD40 (SM00320)  
Conserved Domain (NCBI)FBXW2
DMDM Disease mutations26190
Blocks (Seattle)FBXW2
SuperfamilyQ9UKT8
Human Protein AtlasENSG00000119402
Peptide AtlasQ9UKT8
HPRD09950
IPIIPI00103023   IPI00385182   IPI00647538   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKT8
IntAct (EBI)Q9UKT8
FunCoupENSG00000119402
BioGRIDFBXW2
STRING (EMBL)FBXW2
ZODIACFBXW2
Ontologies - Pathways
QuickGOQ9UKT8
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  cellular protein modification process  proteolysis  protein ubiquitination  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  cellular protein modification process  proteolysis  protein ubiquitination  
NDEx NetworkFBXW2
Atlas of Cancer Signalling NetworkFBXW2
Wikipedia pathwaysFBXW2
Orthology - Evolution
OrthoDB26190
GeneTree (enSembl)ENSG00000119402
Phylogenetic Trees/Animal Genes : TreeFamFBXW2
HOVERGENQ9UKT8
HOGENOMQ9UKT8
Homologs : HomoloGeneFBXW2
Homology/Alignments : Family Browser (UCSC)FBXW2
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP10/FBXW2 [4q31.23/9q33.2]  [t(4;9)(q31;q33)]  
Fusion: TCGAARHGAP10 4q31.23 FBXW2 9q33.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXW2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXW2
dbVarFBXW2
ClinVarFBXW2
1000_GenomesFBXW2 
Exome Variant ServerFBXW2
ExAC (Exome Aggregation Consortium)FBXW2 (select the gene name)
Genetic variants : HAPMAP26190
Genomic Variants (DGV)FBXW2 [DGVbeta]
DECIPHER (Syndromes)9:123519254-123555740  ENSG00000119402
CONAN: Copy Number AnalysisFBXW2 
Mutations
ICGC Data PortalFBXW2 
TCGA Data PortalFBXW2 
Broad Tumor PortalFBXW2
OASIS PortalFBXW2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXW2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXW2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXW2
DgiDB (Drug Gene Interaction Database)FBXW2
DoCM (Curated mutations)FBXW2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXW2 (select a term)
intoGenFBXW2
Cancer3DFBXW2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609071   
Orphanet
MedgenFBXW2
Genetic Testing Registry FBXW2
NextProtQ9UKT8 [Medical]
TSGene26190
GENETestsFBXW2
Huge Navigator FBXW2 [HugePedia]
snp3D : Map Gene to Disease26190
BioCentury BCIQFBXW2
ClinGenFBXW2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26190
Chemical/Pharm GKB GenePA28052
Clinical trialFBXW2
Miscellaneous
canSAR (ICR)FBXW2 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXW2
EVEXFBXW2
GoPubMedFBXW2
iHOPFBXW2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:05:51 CET 2017

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