FCAR (Fc fragment of IgA receptor)

2007-07-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CD89,CTB-61M7.2,FcalphaRI
FUSION GENES

Other Information

Locus ID:

NCBI: 2204
MIM: 147045
HGNC: 3608
Ensembl: ENSG00000186431

Variants:

dbSNP: 2204
ClinVar: 2204
TCGA: ENSG00000186431
COSMIC: FCAR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186431ENST00000345937P24071
ENSG00000186431ENST00000353758P24071
ENSG00000186431ENST00000355524P24071
ENSG00000186431ENST00000359272P24071
ENSG00000186431ENST00000391723P24071
ENSG00000186431ENST00000391724P24071
ENSG00000186431ENST00000391724A0A024R4R4
ENSG00000186431ENST00000391725P24071
ENSG00000186431ENST00000391725A0A024R4N4
ENSG00000186431ENST00000391726P24071
ENSG00000186431ENST00000469767P24071
ENSG00000186431ENST00000469767A0A024R4M5
ENSG00000186431ENST00000488066P24071

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127682052003Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc.66
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
126340592003Bivalent binding of IgA1 to FcalphaRI suggests a mechanism for cytokine activation of IgA phagocytosis.26
208113332010Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy.21
208113332010Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy.21
173394982007FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA.20
213831762011Recognition and functional activation of the human IgA receptor (FcalphaRI) by C-reactive protein.20
216538352011Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy.17
190230992009Gene variants associated with ischemic stroke: the cardiovascular health study.16

Citation

Dessen P

FCAR (Fc fragment of IgA receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47634/fcar