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FCGR2A (Fc fragment of IgG receptor IIa)

Identity

Alias_namesFCG2
FCGR2A1
FCGR2
Fc fragment of IgG, low affinity IIa, receptor for (CD32)
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Alias_symbol (synonym)CD32
CD32A
IGFR2
CDw32
Other aliasFcGR
HGNC (Hugo) FCGR2A
LocusID (NCBI) 2212
Atlas_Id 45528
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 161505415 and ends at 161519570 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSH1 (17q23.3) / FCGR2A (1q23.3)FCGR2A (1q23.3) / SPTA1 (1q23.1)FCGR2A 1q23.3 / SPTA1 1q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FCGR2A   3616
Cards
Entrez_Gene (NCBI)FCGR2A  2212  Fc fragment of IgG receptor IIa
AliasesCD32; CD32A; CDw32; FCG2; 
FCGR2; FCGR2A1; FcGR; IGFR2
GeneCards (Weizmann)FCGR2A
Ensembl hg19 (Hinxton)ENSG00000143226 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143226 [Gene_View]  chr1:161505415-161519570 [Contig_View]  FCGR2A [Vega]
ICGC DataPortalENSG00000143226
TCGA cBioPortalFCGR2A
AceView (NCBI)FCGR2A
Genatlas (Paris)FCGR2A
WikiGenes2212
SOURCE (Princeton)FCGR2A
Genetics Home Reference (NIH)FCGR2A
Genomic and cartography
GoldenPath hg38 (UCSC)FCGR2A  -     chr1:161505415-161519570 +  1q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FCGR2A  -     1q23.3   [Description]    (hg19-Feb_2009)
EnsemblFCGR2A - 1q23.3 [CytoView hg19]  FCGR2A - 1q23.3 [CytoView hg38]
Mapping of homologs : NCBIFCGR2A [Mapview hg19]  FCGR2A [Mapview hg38]
OMIM146790   152700   611162   
Gene and transcription
Genbank (Entrez)AF416711 AI250177 AK225438 AK225601 AK226059
RefSeq transcript (Entrez)NM_001136219 NM_021642
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FCGR2A
Cluster EST : UnigeneHs.352642 [ NCBI ]
CGAP (NCI)Hs.352642
Alternative Splicing GalleryENSG00000143226
Gene ExpressionFCGR2A [ NCBI-GEO ]   FCGR2A [ EBI - ARRAY_EXPRESS ]   FCGR2A [ SEEK ]   FCGR2A [ MEM ]
Gene Expression Viewer (FireBrowse)FCGR2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2212
GTEX Portal (Tissue expression)FCGR2A
Human Protein AtlasENSG00000143226-FCGR2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12318   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP12318  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP12318
Splice isoforms : SwissVarP12318
PhosPhoSitePlusP12318
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2   
Domain families : Pfam (Sanger)Ig_2 (PF13895)   
Domain families : Pfam (NCBI)pfam13895   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)FCGR2A
DMDM Disease mutations2212
Blocks (Seattle)FCGR2A
PDB (SRS)1FCG    1H9V    3D5O    3RY4    3RY5    3RY6   
PDB (PDBSum)1FCG    1H9V    3D5O    3RY4    3RY5    3RY6   
PDB (IMB)1FCG    1H9V    3D5O    3RY4    3RY5    3RY6   
PDB (RSDB)1FCG    1H9V    3D5O    3RY4    3RY5    3RY6   
Structural Biology KnowledgeBase1FCG    1H9V    3D5O    3RY4    3RY5    3RY6   
SCOP (Structural Classification of Proteins)1FCG    1H9V    3D5O    3RY4    3RY5    3RY6   
CATH (Classification of proteins structures)1FCG    1H9V    3D5O    3RY4    3RY5    3RY6   
SuperfamilyP12318
Human Protein Atlas [tissue]ENSG00000143226-FCGR2A [tissue]
Peptide AtlasP12318
HPRD00906
IPIIPI00023505   IPI00646445   IPI00943196   IPI00816820   IPI01015679   IPI01015472   IPI01014888   IPI01014415   
Protein Interaction databases
DIP (DOE-UCLA)P12318
IntAct (EBI)P12318
FunCoupENSG00000143226
BioGRIDFCGR2A
STRING (EMBL)FCGR2A
ZODIACFCGR2A
Ontologies - Pathways
QuickGOP12318
Ontology : AmiGOprotein binding  plasma membrane  integral component of membrane  IgG binding  secretory granule membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  neutrophil degranulation  extracellular exosome  
Ontology : EGO-EBIprotein binding  plasma membrane  integral component of membrane  IgG binding  secretory granule membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  neutrophil degranulation  extracellular exosome  
Pathways : KEGGPhagosome    Osteoclast differentiation    Fc gamma R-mediated phagocytosis    Leishmaniasis    Staphylococcus aureus infection    Tuberculosis    Systemic lupus erythematosus   
NDEx NetworkFCGR2A
Atlas of Cancer Signalling NetworkFCGR2A
Wikipedia pathwaysFCGR2A
Orthology - Evolution
OrthoDB2212
GeneTree (enSembl)ENSG00000143226
Phylogenetic Trees/Animal Genes : TreeFamFCGR2A
HOVERGENP12318
HOGENOMP12318
Homologs : HomoloGeneFCGR2A
Homology/Alignments : Family Browser (UCSC)FCGR2A
Gene fusions - Rearrangements
Fusion : MitelmanFCGR2A/SPTA1 [1q23.3/1q23.1]  
Fusion: TCGA_MDACCFCGR2A 1q23.3 SPTA1 1q23.1 BRCA
Tumor Fusion PortalFCGR2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFCGR2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FCGR2A
dbVarFCGR2A
ClinVarFCGR2A
1000_GenomesFCGR2A 
Exome Variant ServerFCGR2A
ExAC (Exome Aggregation Consortium)ENSG00000143226
GNOMAD BrowserENSG00000143226
Genetic variants : HAPMAP2212
Genomic Variants (DGV)FCGR2A [DGVbeta]
DECIPHERFCGR2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFCGR2A 
Mutations
ICGC Data PortalFCGR2A 
TCGA Data PortalFCGR2A 
Broad Tumor PortalFCGR2A
OASIS PortalFCGR2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFCGR2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFCGR2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch FCGR2A
DgiDB (Drug Gene Interaction Database)FCGR2A
DoCM (Curated mutations)FCGR2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FCGR2A (select a term)
intoGenFCGR2A
Cancer3DFCGR2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146790    152700    611162   
Orphanet
DisGeNETFCGR2A
MedgenFCGR2A
Genetic Testing Registry FCGR2A
NextProtP12318 [Medical]
TSGene2212
GENETestsFCGR2A
Target ValidationFCGR2A
Huge Navigator FCGR2A [HugePedia]
snp3D : Map Gene to Disease2212
BioCentury BCIQFCGR2A
ClinGenFCGR2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2212
Chemical/Pharm GKB GenePA28063
Clinical trialFCGR2A
Miscellaneous
canSAR (ICR)FCGR2A (select the gene name)
Probes
Litterature
PubMed436 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFCGR2A
EVEXFCGR2A
GoPubMedFCGR2A
iHOPFCGR2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:13:06 CET 2017

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