FCGR2A (Fc fragment of IgG receptor IIa)

2007-02-01  

Identity

HGNC
FCGR2A
LOCATION
1q23.3
LOCUSID
2212
ALIAS
CD32,CD32A,CDw32,FCG2,FCGR2,FCGR2A1,FcGR,IGFR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2212
MIM: 146790
HGNC: 3616
Ensembl: ENSG00000143226

Variants:

dbSNP: 2212
ClinVar: 2212
TCGA: ENSG00000143226
COSMIC: FCGR2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143226ENST00000271450P12318
ENSG00000143226ENST00000367972P12318
ENSG00000143226ENST00000459885V9GY55
ENSG00000143226ENST00000467525V9GY83
ENSG00000143226ENST00000483665F5GXY9
ENSG00000143226ENST00000536731F5GX41

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD24048425, 24667440, 25823785, 27044681
PA10040cetuximabChemicalClinicalAnnotationassociatedPD23296156, 27897268, 28719596, 30318772
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD24667440, 25823785, 30457672
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD18347005, 21109570
PA444352Head and Neck NeoplasmsDiseaseClinicalAnnotationassociatedPD23296156, 27897268, 28719596, 30318772
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD24048425, 27044681
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD23296156, 27897268, 28719596, 30318772
PA449515etanerceptChemicalClinicalAnnotationassociatedPD24048425, 27044681
PA451261rituximabChemicalClinicalAnnotationassociatedPD30457672
PA451743trastuzumabChemicalClinicalAnnotationassociatedPD18347005, 21109570
PA452639infliximabChemicalClinicalAnnotationassociatedPD24048425, 24667440, 25823785, 27044681

References

Pubmed IDYearTitleCitations
182044462008Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.488
183470052008Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.303
183470052008Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.303
202287992010Genome-wide association identifies multiple ulcerative colitis susceptibility loci.248
191642132009Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.153
191642132009Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.153
177044202007FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab.138
177044202007FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab.138
198984812009Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.131
129603602003Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG.119

Citation

Dessen P

FCGR2A (Fc fragment of IgG receptor IIa)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45528/fcgr2a