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FDPS (farnesyl diphosphate synthase)

Identity

Alias (NCBI)FPPS
FPS
POROK9
HGNC (Hugo) FDPS
HGNC Alias namefarnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
LocusID (NCBI) 2224
Atlas_Id 43907
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 155308866 and ends at 155320665 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FDPS (1q22) / ATP13A2 (1p36.13)FDPS (1q22) / GPI (19q13.11)FDPS (1q22) / TGIF2 (20q11.23)
FDPS (1q22) / THRA (17q21.1)GPI (19q13.11) / FDPS (1q22)PMM2 (16p13.2) / FDPS (1q22)
THRA (17q21.1) / FDPS (1q22)VPS52 (6p21.32) / FDPS (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FDPS   3631
Cards
Entrez_Gene (NCBI)FDPS    farnesyl diphosphate synthase
AliasesFPPS; FPS; POROK9
GeneCards (Weizmann)FDPS
Ensembl hg19 (Hinxton)ENSG00000160752 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160752 [Gene_View]  ENSG00000160752 [Sequence]  chr1:155308866-155320665 [Contig_View]  FDPS [Vega]
ICGC DataPortalENSG00000160752
TCGA cBioPortalFDPS
AceView (NCBI)FDPS
Genatlas (Paris)FDPS
SOURCE (Princeton)FDPS
Genetics Home Reference (NIH)FDPS
Genomic and cartography
GoldenPath hg38 (UCSC)FDPS  -     chr1:155308866-155320665 +  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FDPS  -     1q22   [Description]    (hg19-Feb_2009)
GoldenPathFDPS - 1q22 [CytoView hg19]  FDPS - 1q22 [CytoView hg38]
ImmunoBaseENSG00000160752
Genome Data Viewer NCBIFDPS [Mapview hg19]  
OMIM134629   616631   
Gene and transcription
Genbank (Entrez)AK021828 AK022841 AK291084 BC010004 BE047993
RefSeq transcript (Entrez)NM_001135821 NM_001135822 NM_001242824 NM_001242825 NM_001378424 NM_001378425 NM_002004
Consensus coding sequences : CCDS (NCBI)FDPS
Gene ExpressionFDPS [ NCBI-GEO ]   FDPS [ EBI - ARRAY_EXPRESS ]   FDPS [ SEEK ]   FDPS [ MEM ]
Gene Expression Viewer (FireBrowse)FDPS [ Firebrowse - Broad ]
GenevisibleExpression of FDPS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2224
GTEX Portal (Tissue expression)FDPS
Human Protein AtlasENSG00000160752-FDPS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14324   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14324  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14324
PhosPhoSitePlusP14324
Domaine pattern : Prosite (Expaxy)POLYPRENYL_SYNTHASE_1 (PS00723)    POLYPRENYL_SYNTHASE_2 (PS00444)   
Domains : Interpro (EBI)Isoprenoid_synthase_dom_sf    Polyprenyl_synt    Polyprenyl_synt_CS   
Domain families : Pfam (Sanger)polyprenyl_synt (PF00348)   
Domain families : Pfam (NCBI)pfam00348   
Conserved Domain (NCBI)FDPS
PDB (RSDB)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX    5YGI    6N7Y    6N7Z    6N82    6N83    6OAG    6OAH   
PDB Europe1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX    5YGI    6N7Y    6N7Z    6N82    6N83    6OAG    6OAH   
PDB (PDBSum)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX    5YGI    6N7Y    6N7Z    6N82    6N83    6OAG    6OAH   
PDB (IMB)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX    5YGI    6N7Y    6N7Z    6N82    6N83    6OAG    6OAH   
Structural Biology KnowledgeBase1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX    5YGI    6N7Y    6N7Z    6N82    6N83    6OAG    6OAH   
SCOP (Structural Classification of Proteins)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX    5YGI    6N7Y    6N7Z    6N82    6N83    6OAG    6OAH   
CATH (Classification of proteins structures)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX    5YGI    6N7Y    6N7Z    6N82    6N83    6OAG    6OAH   
SuperfamilyP14324
AlphaFold pdb e-kbP14324   
Human Protein Atlas [tissue]ENSG00000160752-FDPS [tissue]
HPRD00606
Protein Interaction databases
DIP (DOE-UCLA)P14324
IntAct (EBI)P14324
BioGRIDFDPS
STRING (EMBL)FDPS
ZODIACFDPS
Ontologies - Pathways
QuickGOP14324
Ontology : AmiGORNA binding  dimethylallyltranstransferase activity  geranyltranstransferase activity  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  cholesterol biosynthetic process  regulation of lipid metabolic process  geranyl diphosphate biosynthetic process  farnesyl diphosphate biosynthetic process  farnesyl diphosphate biosynthetic process  metal ion binding  
Ontology : EGO-EBIRNA binding  dimethylallyltranstransferase activity  geranyltranstransferase activity  protein binding  nucleoplasm  cytoplasm  cytosol  cytosol  cholesterol biosynthetic process  regulation of lipid metabolic process  geranyl diphosphate biosynthetic process  farnesyl diphosphate biosynthetic process  farnesyl diphosphate biosynthetic process  metal ion binding  
Pathways : KEGGTerpenoid backbone biosynthesis    Influenza A    HTLV-I infection   
NDEx NetworkFDPS
Atlas of Cancer Signalling NetworkFDPS
Wikipedia pathwaysFDPS
Orthology - Evolution
OrthoDB2224
GeneTree (enSembl)ENSG00000160752
Phylogenetic Trees/Animal Genes : TreeFamFDPS
Homologs : HomoloGeneFDPS
Homology/Alignments : Family Browser (UCSC)FDPS
Gene fusions - Rearrangements
Fusion : QuiverFDPS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFDPS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FDPS
dbVarFDPS
ClinVarFDPS
MonarchFDPS
1000_GenomesFDPS 
Exome Variant ServerFDPS
GNOMAD BrowserENSG00000160752
Varsome BrowserFDPS
ACMGFDPS variants
VarityP14324
Genomic Variants (DGV)FDPS [DGVbeta]
DECIPHERFDPS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFDPS 
Mutations
ICGC Data PortalFDPS 
TCGA Data PortalFDPS 
Broad Tumor PortalFDPS
OASIS PortalFDPS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFDPS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFDPS
Mutations and Diseases : HGMDFDPS
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFDPS
DgiDB (Drug Gene Interaction Database)FDPS
DoCM (Curated mutations)FDPS
CIViC (Clinical Interpretations of Variants in Cancer)FDPS
Cancer3DFDPS
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134629    616631   
Orphanet11178   
DisGeNETFDPS
MedgenFDPS
Genetic Testing Registry FDPS
NextProtP14324 [Medical]
GENETestsFDPS
Target ValidationFDPS
Huge Navigator FDPS [HugePedia]
ClinGenFDPS
Clinical trials, drugs, therapy
MyCancerGenomeFDPS
Protein Interactions : CTDFDPS
Pharm GKB GenePA28075
Pharm GKB PathwaysPA154423660   
PharosP14324
Clinical trialFDPS
Miscellaneous
canSAR (ICR)FDPS
HarmonizomeFDPS
DataMed IndexFDPS
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFDPS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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