FDPS (farnesyl diphosphate synthase)

2007-02-01  

Identity

HGNC
LOCATION
1q22
LOCUSID
ALIAS
FPPS,FPS,POROK9
FUSION GENES

Other Information

Locus ID:

NCBI: 2224
MIM: 134629
HGNC: 3631
Ensembl: ENSG00000160752

Variants:

dbSNP: 2224
ClinVar: 2224
TCGA: ENSG00000160752
COSMIC: FDPS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160752ENST00000356657P14324
ENSG00000160752ENST00000368356P14324
ENSG00000160752ENST00000447866P14324
ENSG00000160752ENST00000465559A0A087X1D8
ENSG00000160752ENST00000467076P14324
ENSG00000160752ENST00000474345A0A087WTP2
ENSG00000160752ENST00000491013A0A087WVN4
ENSG00000160752ENST00000611010A0A087X090
ENSG00000160752ENST00000612683P14324

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Terpenoid backbone biosynthesisKEGGko00900
Terpenoid backbone biosynthesisKEGGhsa00900
Metabolic pathwaysKEGGhsa01100
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Cholesterol biosynthesisREACTOMER-HSA-191273
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10235zoledronateChemicalClinicalAnnotationassociatedPD21196316
PA164712563BisphosphonatesChemicalClinicalAnnotationassociatedPD18687167, 21151198, 24311107
PA443797Coronary DiseaseDiseaseClinicalAnnotationassociatedPD21151198, 24311107
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD21196316
PA445187OsteonecrosisDiseaseClinicalAnnotationassociatedPD21196316
PA445190OsteoporosisDiseaseClinicalAnnotationassociatedPD18687167, 21151198, 24311107
PA446214Osteoporosis, PostmenopausalDiseaseClinicalAnnotationassociatedPD18687167, 21151198
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD21151198, 24311107

References

Pubmed IDYearTitleCitations
194943382009Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells.31
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
173875282007Association study of cholesterol-related genes in Alzheimer's disease.16
290750412017Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma.13
157139902004Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis.12
249275482014Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.11
171987372007Mitochondrial targeting of farnesyl diphosphate synthase is a widespread phenomenon in eukaryotes.10
184949342008Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells.10
232772742013Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.10

Citation

Dessen P

FDPS (farnesyl diphosphate synthase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43907/fdps