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FDPS (farnesyl diphosphate synthase)

Identity

Alias_namesdimethylallyltranstransferase
geranyltranstransferase
Other aliasFPPS
FPS
POROK9
HGNC (Hugo) FDPS
LocusID (NCBI) 2224
Atlas_Id 43907
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 155308748 and ends at 155320666 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FDPS (1q22) / ATP13A2 (1p36.13)FDPS (1q22) / GPI (19q13.11)FDPS (1q22) / TGIF2 (20q11.23)
FDPS (1q22) / THRA (17q21.1)GPI (19q13.11) / FDPS (1q22)PMM2 (16p13.2) / FDPS (1q22)
THRA (17q21.1) / FDPS (1q22)VPS52 (6p21.32) / FDPS (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FDPS   3631
Cards
Entrez_Gene (NCBI)FDPS  2224  farnesyl diphosphate synthase
AliasesFPPS; FPS; POROK9
GeneCards (Weizmann)FDPS
Ensembl hg19 (Hinxton)ENSG00000160752 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160752 [Gene_View]  ENSG00000160752 [Sequence]  chr1:155308748-155320666 [Contig_View]  FDPS [Vega]
ICGC DataPortalENSG00000160752
TCGA cBioPortalFDPS
AceView (NCBI)FDPS
Genatlas (Paris)FDPS
WikiGenes2224
SOURCE (Princeton)FDPS
Genetics Home Reference (NIH)FDPS
Genomic and cartography
GoldenPath hg38 (UCSC)FDPS  -     chr1:155308748-155320666 +  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FDPS  -     1q22   [Description]    (hg19-Feb_2009)
EnsemblFDPS - 1q22 [CytoView hg19]  FDPS - 1q22 [CytoView hg38]
Mapping of homologs : NCBIFDPS [Mapview hg19]  FDPS [Mapview hg38]
OMIM134629   616631   
Gene and transcription
Genbank (Entrez)AK021828 AK022841 AK291084 BC010004 BE047993
RefSeq transcript (Entrez)NM_001135821 NM_001135822 NM_001242824 NM_001242825 NM_002004
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FDPS
Cluster EST : UnigeneHs.335918 [ NCBI ]
CGAP (NCI)Hs.335918
Alternative Splicing GalleryENSG00000160752
Gene ExpressionFDPS [ NCBI-GEO ]   FDPS [ EBI - ARRAY_EXPRESS ]   FDPS [ SEEK ]   FDPS [ MEM ]
Gene Expression Viewer (FireBrowse)FDPS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2224
GTEX Portal (Tissue expression)FDPS
Human Protein AtlasENSG00000160752-FDPS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14324   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14324  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14324
Splice isoforms : SwissVarP14324
Catalytic activity : Enzyme2.5.1.10 [ Enzyme-Expasy ]   2.5.1.102.5.1.10 [ IntEnz-EBI ]   2.5.1.10 [ BRENDA ]   2.5.1.10 [ KEGG ]   
PhosPhoSitePlusP14324
Domaine pattern : Prosite (Expaxy)POLYPRENYL_SYNTHASE_1 (PS00723)    POLYPRENYL_SYNTHASE_2 (PS00444)   
Domains : Interpro (EBI)Isoprenoid_synthase_dom_sf    Polyprenyl_synt    Polyprenyl_synt_CS   
Domain families : Pfam (Sanger)polyprenyl_synt (PF00348)   
Domain families : Pfam (NCBI)pfam00348   
Conserved Domain (NCBI)FDPS
DMDM Disease mutations2224
Blocks (Seattle)FDPS
PDB (SRS)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX   
PDB (PDBSum)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX   
PDB (IMB)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX   
PDB (RSDB)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX   
Structural Biology KnowledgeBase1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX   
SCOP (Structural Classification of Proteins)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX   
CATH (Classification of proteins structures)1YQ7    1YV5    1ZW5    2F7M    2F89    2F8C    2F8Z    2F92    2F94    2F9K    2OPM    2OPN    2QIS    2RAH    2VF6    3B7L    3CP6    3N1V    3N1W    3N3L    3N45    3N46    3N49    3N5H    3N5J    3N6K    3RYE    3S4J    4DEM    4GA3    4H5C    4H5D    4H5E    4JVJ    4KFA    4KPD    4KPJ    4KQ5    4KQS    4KQU    4L2X    4LFV    4LPG    4LPH    4N1Z    4N9U    4NFI    4NFJ    4NFK    4NG6    4NKE    4NKF    4NUA    4OGU    4P0V    4P0W    4P0X    4PVX    4PVY    4Q23    4QPF    4QXS    4RXA    4XQR    4XQS    4XQT    5CG5    5CG6    5DGM    5DGN    5DGS    5DIQ    5DJP    5DJR    5DJV    5JA0    5JUZ    5JV0    5JV1    5JV2    5KSX   
SuperfamilyP14324
Human Protein Atlas [tissue]ENSG00000160752-FDPS [tissue]
Peptide AtlasP14324
HPRD00606
IPIIPI00914566   IPI00382869   IPI00914971   
Protein Interaction databases
DIP (DOE-UCLA)P14324
IntAct (EBI)P14324
FunCoupENSG00000160752
BioGRIDFDPS
STRING (EMBL)FDPS
ZODIACFDPS
Ontologies - Pathways
QuickGOP14324
Ontology : AmiGORNA binding  dimethylallyltranstransferase activity  dimethylallyltranstransferase activity  geranyltranstransferase activity  geranyltranstransferase activity  nucleoplasm  cytoplasm  cytosol  cytosol  cholesterol biosynthetic process  viral process  geranyl diphosphate biosynthetic process  farnesyl diphosphate biosynthetic process  farnesyl diphosphate biosynthetic process  regulation of cholesterol biosynthetic process  metal ion binding  
Ontology : EGO-EBIRNA binding  dimethylallyltranstransferase activity  dimethylallyltranstransferase activity  geranyltranstransferase activity  geranyltranstransferase activity  nucleoplasm  cytoplasm  cytosol  cytosol  cholesterol biosynthetic process  viral process  geranyl diphosphate biosynthetic process  farnesyl diphosphate biosynthetic process  farnesyl diphosphate biosynthetic process  regulation of cholesterol biosynthetic process  metal ion binding  
Pathways : KEGGTerpenoid backbone biosynthesis    Influenza A    HTLV-I infection   
NDEx NetworkFDPS
Atlas of Cancer Signalling NetworkFDPS
Wikipedia pathwaysFDPS
Orthology - Evolution
OrthoDB2224
GeneTree (enSembl)ENSG00000160752
Phylogenetic Trees/Animal Genes : TreeFamFDPS
HOVERGENP14324
HOGENOMP14324
Homologs : HomoloGeneFDPS
Homology/Alignments : Family Browser (UCSC)FDPS
Gene fusions - Rearrangements
Fusion : QuiverFDPS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFDPS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FDPS
dbVarFDPS
ClinVarFDPS
1000_GenomesFDPS 
Exome Variant ServerFDPS
ExAC (Exome Aggregation Consortium)ENSG00000160752
GNOMAD BrowserENSG00000160752
Varsome BrowserFDPS
Genetic variants : HAPMAP2224
Genomic Variants (DGV)FDPS [DGVbeta]
DECIPHERFDPS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFDPS 
Mutations
ICGC Data PortalFDPS 
TCGA Data PortalFDPS 
Broad Tumor PortalFDPS
OASIS PortalFDPS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFDPS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFDPS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch FDPS
DgiDB (Drug Gene Interaction Database)FDPS
DoCM (Curated mutations)FDPS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FDPS (select a term)
intoGenFDPS
Cancer3DFDPS(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134629    616631   
Orphanet11178   
DisGeNETFDPS
MedgenFDPS
Genetic Testing Registry FDPS
NextProtP14324 [Medical]
TSGene2224
GENETestsFDPS
Target ValidationFDPS
Huge Navigator FDPS [HugePedia]
snp3D : Map Gene to Disease2224
BioCentury BCIQFDPS
ClinGenFDPS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2224
Chemical/Pharm GKB GenePA28075
Clinical trialFDPS
Miscellaneous
canSAR (ICR)FDPS (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFDPS
EVEXFDPS
GoPubMedFDPS
iHOPFDPS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:22:50 CEST 2018

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