FMO3 (flavin containing dimethylaniline monoxygenase 3)

2007-02-01  

Identity

HGNC
FMO3
LOCATION
1q24.3
LOCUSID
2328
ALIAS
FMOII,TMAU,dJ127D3.1

Other Information

Locus ID:

NCBI: 2328
MIM: 136132
HGNC: 3771
Ensembl: ENSG00000007933

Variants:

dbSNP: 2328
ClinVar: 2328
TCGA: ENSG00000007933
COSMIC: FMO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007933ENST00000367755P31513
ENSG00000007933ENST00000367755A0A024R8Z4
ENSG00000007933ENST00000472784V9GYP3
ENSG00000007933ENST00000479749V9GZ60

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - cytochrome P450KEGGhsa00982
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
FMO oxidises nucleophilesREACTOMER-HSA-217271

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD21900104, 23441093
PA134308647rosuvastatinChemicalClinicalAnnotationassociatedPD20679960
PA152432599itoprideChemicalClinicalAnnotationassociatedPK25224784
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD21900104, 23441093
PA445876Tobacco Use DisorderDiseaseClinicalAnnotationassociatedPK28290528
PA447247liver transplantationDiseaseVariantAnnotationassociatedPK28084894
PA449212daunorubicinChemicalMultilinkAnnotationassociated25119182
PA450626nicotineChemicalClinicalAnnotationassociatedPK28290528
PA450688olanzapineChemicalClinicalAnnotationassociatedPK23147717
PA451565sulindacChemicalClinicalAnnotationassociatedPK
PA451578tacrolimusChemicalVariantAnnotationassociatedPK28084894
PA451581tamoxifenChemicalPathwayassociated23962908

References

Pubmed IDYearTitleCitations
258491382015Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis.87
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
201730832010Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.44
118099202002Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression.41
184433012008Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase.38
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
161837782006Quantitative analysis of FMO gene mRNA levels in human tissues.30
172574342007Transient trimethylaminuria related to menstruation.20
168008222006Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans.18
168008222006Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans.18

Citation

Dessen P

FMO3 (flavin containing dimethylaniline monoxygenase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45891/fmo3