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FNTA (farnesyltransferase, CAAX box, alpha)

Identity

Alias (NCBI)FPTA
PGGT1A
PTAR2
HGNC (Hugo) FNTA
HGNC Alias symbFPTA
PGGT1A
PTAR2
HGNC Alias nameprotein prenyltransferase alpha subunit repeat containing 2
 protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
LocusID (NCBI) 2339
Atlas_Id 40618
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 43056323 and ends at 43085782 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEP72 (5p15.33) / FNTA (8p11.21)FNTA (8p11.21) / FNTA (8p11.21)FNTA (8p11.21) / OVOL1 (11q13.1)
FNTA (8p11.21) / SPIDR (8q11.21)FNTA (8p11.21) / ZMAT4 (8p11.21)RNF170 (8p11.21) / FNTA (8p11.21)
FNTA 8p11.21 KIAA0146FNTA 8p11.21 / OVOL1 11q13.1FNTA 8p11.21 / ZMAT4 8p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FNTA   3782
Cards
Entrez_Gene (NCBI)FNTA    farnesyltransferase, CAAX box, alpha
AliasesFPTA; PGGT1A; PTAR2
GeneCards (Weizmann)FNTA
Ensembl hg19 (Hinxton)ENSG00000168522 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168522 [Gene_View]  ENSG00000168522 [Sequence]  chr8:43056323-43085782 [Contig_View]  FNTA [Vega]
ICGC DataPortalENSG00000168522
TCGA cBioPortalFNTA
AceView (NCBI)FNTA
Genatlas (Paris)FNTA
SOURCE (Princeton)FNTA
Genetics Home Reference (NIH)FNTA
Genomic and cartography
GoldenPath hg38 (UCSC)FNTA  -     chr8:43056323-43085782 +  8p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FNTA  -     8p11.21   [Description]    (hg19-Feb_2009)
GoldenPathFNTA - 8p11.21 [CytoView hg19]  FNTA - 8p11.21 [CytoView hg38]
ImmunoBaseENSG00000168522
Genome Data Viewer NCBIFNTA [Mapview hg19]  
OMIM134635   
Gene and transcription
Genbank (Entrez)AB209689 AK091717 AK123002 AK292121 AL698961
RefSeq transcript (Entrez)NM_001018676 NM_001018677 NM_002027
Consensus coding sequences : CCDS (NCBI)FNTA
Gene ExpressionFNTA [ NCBI-GEO ]   FNTA [ EBI - ARRAY_EXPRESS ]   FNTA [ SEEK ]   FNTA [ MEM ]
Gene Expression Viewer (FireBrowse)FNTA [ Firebrowse - Broad ]
GenevisibleExpression of FNTA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2339
GTEX Portal (Tissue expression)FNTA
Human Protein AtlasENSG00000168522-FNTA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49354   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49354  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49354
PhosPhoSitePlusP49354
Domaine pattern : Prosite (Expaxy)PFTA (PS51147)   
Domains : Interpro (EBI)Prenyl_trans_a   
Domain families : Pfam (Sanger)PPTA (PF01239)   
Domain families : Pfam (NCBI)pfam01239   
Conserved Domain (NCBI)FNTA
PDB (RSDB)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
PDB Europe1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
PDB (PDBSum)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
PDB (IMB)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
Structural Biology KnowledgeBase1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
SCOP (Structural Classification of Proteins)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
CATH (Classification of proteins structures)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
SuperfamilyP49354
AlphaFold pdb e-kbP49354   
Human Protein Atlas [tissue]ENSG00000168522-FNTA [tissue]
HPRD00607
Protein Interaction databases
DIP (DOE-UCLA)P49354
IntAct (EBI)P49354
BioGRIDFNTA
STRING (EMBL)FNTA
ZODIACFNTA
Ontologies - Pathways
QuickGOP49354
Ontology : AmiGOMAPK cascade  protein farnesyltransferase activity  protein farnesyltransferase activity  protein farnesyltransferase activity  protein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase activity  Rab geranylgeranyltransferase activity  protein binding  cytoplasm  cytosol  microtubule associated complex  plasma membrane  CAAX-protein geranylgeranyltransferase complex  CAAX-protein geranylgeranyltransferase complex  protein farnesyltransferase complex  protein farnesyltransferase complex  transforming growth factor beta receptor signaling pathway  microtubule binding  protein farnesylation  protein farnesylation  protein geranylgeranylation  protein geranylgeranylation  regulation of rhodopsin mediated signaling pathway  acetylcholine receptor regulator activity  receptor tyrosine kinase binding  alpha-tubulin binding  neurotransmitter receptor metabolic process  skeletal muscle acetylcholine-gated channel clustering  positive regulation of tubulin deacetylation  positive regulation of deacetylase activity  
Ontology : EGO-EBIMAPK cascade  protein farnesyltransferase activity  protein farnesyltransferase activity  protein farnesyltransferase activity  protein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase activity  Rab geranylgeranyltransferase activity  protein binding  cytoplasm  cytosol  microtubule associated complex  plasma membrane  CAAX-protein geranylgeranyltransferase complex  CAAX-protein geranylgeranyltransferase complex  protein farnesyltransferase complex  protein farnesyltransferase complex  transforming growth factor beta receptor signaling pathway  microtubule binding  protein farnesylation  protein farnesylation  protein geranylgeranylation  protein geranylgeranylation  regulation of rhodopsin mediated signaling pathway  acetylcholine receptor regulator activity  receptor tyrosine kinase binding  alpha-tubulin binding  neurotransmitter receptor metabolic process  skeletal muscle acetylcholine-gated channel clustering  positive regulation of tubulin deacetylation  positive regulation of deacetylase activity  
Pathways : KEGGTerpenoid backbone biosynthesis   
NDEx NetworkFNTA
Atlas of Cancer Signalling NetworkFNTA
Wikipedia pathwaysFNTA
Orthology - Evolution
OrthoDB2339
GeneTree (enSembl)ENSG00000168522
Phylogenetic Trees/Animal Genes : TreeFamFNTA
Homologs : HomoloGeneFNTA
Homology/Alignments : Family Browser (UCSC)FNTA
Gene fusions - Rearrangements
Fusion : MitelmanFNTA/OVOL1 [8p11.21/11q13.1]  
Fusion : MitelmanFNTA/SPIDR [8p11.21/8q11.21]  
Fusion : MitelmanFNTA/ZMAT4 [8p11.21/8p11.21]  
Fusion : QuiverFNTA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFNTA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FNTA
dbVarFNTA
ClinVarFNTA
MonarchFNTA
1000_GenomesFNTA 
Exome Variant ServerFNTA
GNOMAD BrowserENSG00000168522
Varsome BrowserFNTA
ACMGFNTA variants
VarityP49354
Genomic Variants (DGV)FNTA [DGVbeta]
DECIPHERFNTA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFNTA 
Mutations
ICGC Data PortalFNTA 
TCGA Data PortalFNTA 
Broad Tumor PortalFNTA
OASIS PortalFNTA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFNTA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFNTA
Mutations and Diseases : HGMDFNTA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFNTA
DgiDB (Drug Gene Interaction Database)FNTA
DoCM (Curated mutations)FNTA
CIViC (Clinical Interpretations of Variants in Cancer)FNTA
Cancer3DFNTA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134635   
Orphanet
DisGeNETFNTA
MedgenFNTA
Genetic Testing Registry FNTA
NextProtP49354 [Medical]
GENETestsFNTA
Target ValidationFNTA
Huge Navigator FNTA [HugePedia]
ClinGenFNTA
Clinical trials, drugs, therapy
MyCancerGenomeFNTA
Protein Interactions : CTDFNTA
Pharm GKB GenePA28199
PharosP49354
Clinical trialFNTA
Miscellaneous
canSAR (ICR)FNTA
HarmonizomeFNTA
DataMed IndexFNTA
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFNTA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:09:44 CEST 2021

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