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FNTA (farnesyltransferase, CAAX box, alpha)

Identity

Alias_symbol (synonym)FPTA
PGGT1A
PTAR2
Other alias
HGNC (Hugo) FNTA
LocusID (NCBI) 2339
Atlas_Id 40618
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 43056299 and ends at 43085788 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CEP72 (5p15.33) / FNTA (8p11.21)FNTA (8p11.21) / FNTA (8p11.21)FNTA (8p11.21) / OVOL1 (11q13.1)
FNTA (8p11.21) / SPIDR (8q11.21)FNTA (8p11.21) / ZMAT4 (8p11.21)RNF170 (8p11.21) / FNTA (8p11.21)
FNTA 8p11.21 KIAA0146FNTA 8p11.21 / OVOL1 11q13.1FNTA 8p11.21 / ZMAT4 8p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FNTA   3782
Cards
Entrez_Gene (NCBI)FNTA  2339  farnesyltransferase, CAAX box, alpha
AliasesFPTA; PGGT1A; PTAR2
GeneCards (Weizmann)FNTA
Ensembl hg19 (Hinxton)ENSG00000168522 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168522 [Gene_View]  chr8:43056299-43085788 [Contig_View]  FNTA [Vega]
ICGC DataPortalENSG00000168522
TCGA cBioPortalFNTA
AceView (NCBI)FNTA
Genatlas (Paris)FNTA
WikiGenes2339
SOURCE (Princeton)FNTA
Genetics Home Reference (NIH)FNTA
Genomic and cartography
GoldenPath hg38 (UCSC)FNTA  -     chr8:43056299-43085788 +  8p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FNTA  -     8p11.21   [Description]    (hg19-Feb_2009)
EnsemblFNTA - 8p11.21 [CytoView hg19]  FNTA - 8p11.21 [CytoView hg38]
Mapping of homologs : NCBIFNTA [Mapview hg19]  FNTA [Mapview hg38]
OMIM134635   
Gene and transcription
Genbank (Entrez)AB209689 AK091717 AK123002 AK292121 AL698961
RefSeq transcript (Entrez)NM_001018676 NM_001018677 NM_002027
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FNTA
Cluster EST : UnigeneHs.370312 [ NCBI ]
CGAP (NCI)Hs.370312
Alternative Splicing GalleryENSG00000168522
Gene ExpressionFNTA [ NCBI-GEO ]   FNTA [ EBI - ARRAY_EXPRESS ]   FNTA [ SEEK ]   FNTA [ MEM ]
Gene Expression Viewer (FireBrowse)FNTA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2339
GTEX Portal (Tissue expression)FNTA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49354   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49354  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49354
Splice isoforms : SwissVarP49354
PhosPhoSitePlusP49354
Domaine pattern : Prosite (Expaxy)PFTA (PS51147)   
Domains : Interpro (EBI)Prenyl_trans_a   
Domain families : Pfam (Sanger)PPTA (PF01239)   
Domain families : Pfam (NCBI)pfam01239   
Conserved Domain (NCBI)FNTA
DMDM Disease mutations2339
Blocks (Seattle)FNTA
PDB (SRS)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
PDB (PDBSum)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
PDB (IMB)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
PDB (RSDB)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
Structural Biology KnowledgeBase1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
SCOP (Structural Classification of Proteins)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
CATH (Classification of proteins structures)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
SuperfamilyP49354
Human Protein AtlasENSG00000168522
Peptide AtlasP49354
HPRD00607
IPIIPI00607601   IPI00026813   IPI00816195   IPI00976205   IPI00975531   IPI01014486   IPI00976845   
Protein Interaction databases
DIP (DOE-UCLA)P49354
IntAct (EBI)P49354
FunCoupENSG00000168522
BioGRIDFNTA
STRING (EMBL)FNTA
ZODIACFNTA
Ontologies - Pathways
QuickGOP49354
Ontology : AmiGOprotein farnesyltransferase activity  protein farnesyltransferase activity  protein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase activity  Rab geranylgeranyltransferase activity  protein binding  cytoplasm  cytosol  microtubule associated complex  plasma membrane  CAAX-protein geranylgeranyltransferase complex  protein farnesyltransferase complex  transforming growth factor beta receptor signaling pathway  microtubule binding  protein farnesylation  protein geranylgeranylation  regulation of rhodopsin mediated signaling pathway  acetylcholine receptor regulator activity  receptor tyrosine kinase binding  alpha-tubulin binding  neurotransmitter receptor metabolic process  skeletal muscle acetylcholine-gated channel clustering  positive regulation of tubulin deacetylation  positive regulation of deacetylase activity  execution phase of apoptosis  regulation of neurotransmitter receptor activity  
Ontology : EGO-EBIprotein farnesyltransferase activity  protein farnesyltransferase activity  protein geranylgeranyltransferase activity  CAAX-protein geranylgeranyltransferase activity  Rab geranylgeranyltransferase activity  protein binding  cytoplasm  cytosol  microtubule associated complex  plasma membrane  CAAX-protein geranylgeranyltransferase complex  protein farnesyltransferase complex  transforming growth factor beta receptor signaling pathway  microtubule binding  protein farnesylation  protein geranylgeranylation  regulation of rhodopsin mediated signaling pathway  acetylcholine receptor regulator activity  receptor tyrosine kinase binding  alpha-tubulin binding  neurotransmitter receptor metabolic process  skeletal muscle acetylcholine-gated channel clustering  positive regulation of tubulin deacetylation  positive regulation of deacetylase activity  execution phase of apoptosis  regulation of neurotransmitter receptor activity  
Pathways : KEGGTerpenoid backbone biosynthesis   
NDEx NetworkFNTA
Atlas of Cancer Signalling NetworkFNTA
Wikipedia pathwaysFNTA
Orthology - Evolution
OrthoDB2339
GeneTree (enSembl)ENSG00000168522
Phylogenetic Trees/Animal Genes : TreeFamFNTA
HOVERGENP49354
HOGENOMP49354
Homologs : HomoloGeneFNTA
Homology/Alignments : Family Browser (UCSC)FNTA
Gene fusions - Rearrangements
Fusion : MitelmanFNTA/OVOL1 [8p11.21/11q13.1]  
Fusion : MitelmanFNTA/SPIDR [8p11.21/8q11.21]  [t(8;8)(p11;q11)]  
Fusion : MitelmanFNTA/ZMAT4 [8p11.21/8p11.21]  [t(8;8)(p11;p11)]  
Fusion: TCGAFNTA 8p11.21 KIAA0146 LUAD
Fusion: TCGAFNTA 8p11.21 OVOL1 11q13.1 BRCA
Fusion: TCGAFNTA 8p11.21 ZMAT4 8p11.21 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFNTA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FNTA
dbVarFNTA
ClinVarFNTA
1000_GenomesFNTA 
Exome Variant ServerFNTA
ExAC (Exome Aggregation Consortium)FNTA (select the gene name)
Genetic variants : HAPMAP2339
Genomic Variants (DGV)FNTA [DGVbeta]
DECIPHERFNTA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFNTA 
Mutations
ICGC Data PortalFNTA 
TCGA Data PortalFNTA 
Broad Tumor PortalFNTA
OASIS PortalFNTA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFNTA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFNTA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FNTA
DgiDB (Drug Gene Interaction Database)FNTA
DoCM (Curated mutations)FNTA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FNTA (select a term)
intoGenFNTA
Cancer3DFNTA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134635   
Orphanet
MedgenFNTA
Genetic Testing Registry FNTA
NextProtP49354 [Medical]
TSGene2339
GENETestsFNTA
Target ValidationFNTA
Huge Navigator FNTA [HugePedia]
snp3D : Map Gene to Disease2339
BioCentury BCIQFNTA
ClinGenFNTA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2339
Chemical/Pharm GKB GenePA28199
Clinical trialFNTA
Miscellaneous
canSAR (ICR)FNTA (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFNTA
EVEXFNTA
GoPubMedFNTA
iHOPFNTA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:34:11 CEST 2017

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