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FPGS (folylpolyglutamate synthase)

Identity

Other alias-
HGNC (Hugo) FPGS
LocusID (NCBI) 2356
Atlas_Id 45986
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 127803181 and ends at 127814081 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COBL (7p12.1) / FPGS (9q34.11)FPGS (9q34.11) / FPGS (9q34.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FPGS   3824
Cards
Entrez_Gene (NCBI)FPGS  2356  folylpolyglutamate synthase
Aliases
GeneCards (Weizmann)FPGS
Ensembl hg19 (Hinxton)ENSG00000136877 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136877 [Gene_View]  chr9:127803181-127814081 [Contig_View]  FPGS [Vega]
ICGC DataPortalENSG00000136877
TCGA cBioPortalFPGS
AceView (NCBI)FPGS
Genatlas (Paris)FPGS
WikiGenes2356
SOURCE (Princeton)FPGS
Genetics Home Reference (NIH)FPGS
Genomic and cartography
GoldenPath hg38 (UCSC)FPGS  -     chr9:127803181-127814081 +  9q34.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FPGS  -     9q34.11   [Description]    (hg19-Feb_2009)
EnsemblFPGS - 9q34.11 [CytoView hg19]  FPGS - 9q34.11 [CytoView hg38]
Mapping of homologs : NCBIFPGS [Mapview hg19]  FPGS [Mapview hg38]
OMIM136510   
Gene and transcription
Genbank (Entrez)AK056920 AK295309 AK315523 AY007210 AY007211
RefSeq transcript (Entrez)NM_001018078 NM_001288803 NM_004957
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FPGS
Cluster EST : UnigeneHs.335084 [ NCBI ]
CGAP (NCI)Hs.335084
Alternative Splicing GalleryENSG00000136877
Gene ExpressionFPGS [ NCBI-GEO ]   FPGS [ EBI - ARRAY_EXPRESS ]   FPGS [ SEEK ]   FPGS [ MEM ]
Gene Expression Viewer (FireBrowse)FPGS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2356
GTEX Portal (Tissue expression)FPGS
Human Protein AtlasENSG00000136877-FPGS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05932   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05932  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05932
Splice isoforms : SwissVarQ05932
Catalytic activity : Enzyme6.3.2.17 [ Enzyme-Expasy ]   6.3.2.176.3.2.17 [ IntEnz-EBI ]   6.3.2.17 [ BRENDA ]   6.3.2.17 [ KEGG ]   
PhosPhoSitePlusQ05932
Domaine pattern : Prosite (Expaxy)FOLYLPOLYGLU_SYNT_1 (PS01011)    FOLYLPOLYGLU_SYNT_2 (PS01012)   
Domains : Interpro (EBI)Folylpolyglutamate_synth    Folylpolyglutamate_synth_CS    Folylpolyglutamate_synth_euk    Mur_ligase_C    Mur_ligase_cen   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)FPGS
DMDM Disease mutations2356
Blocks (Seattle)FPGS
SuperfamilyQ05932
Human Protein Atlas [tissue]ENSG00000136877-FPGS [tissue]
Peptide AtlasQ05932
HPRD00642
IPIIPI00016745   IPI00759584   IPI00552800   IPI00470735   IPI00815981   IPI00552632   IPI00639911   
Protein Interaction databases
DIP (DOE-UCLA)Q05932
IntAct (EBI)Q05932
FunCoupENSG00000136877
BioGRIDFPGS
STRING (EMBL)FPGS
ZODIACFPGS
Ontologies - Pathways
QuickGOQ05932
Ontology : AmiGOliver development  tetrahydrofolylpolyglutamate synthase activity  tetrahydrofolylpolyglutamate synthase activity  ATP binding  cytoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  cytosol  nucleobase-containing compound metabolic process  glutamate metabolic process  one-carbon metabolic process  folic acid-containing compound metabolic process  brain development  animal organ regeneration  folic acid metabolic process  metal ion binding  tetrahydrofolylpolyglutamate biosynthetic process  tetrahydrofolylpolyglutamate biosynthetic process  
Ontology : EGO-EBIliver development  tetrahydrofolylpolyglutamate synthase activity  tetrahydrofolylpolyglutamate synthase activity  ATP binding  cytoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  cytosol  nucleobase-containing compound metabolic process  glutamate metabolic process  one-carbon metabolic process  folic acid-containing compound metabolic process  brain development  animal organ regeneration  folic acid metabolic process  metal ion binding  tetrahydrofolylpolyglutamate biosynthetic process  tetrahydrofolylpolyglutamate biosynthetic process  
Pathways : KEGGFolate biosynthesis   
NDEx NetworkFPGS
Atlas of Cancer Signalling NetworkFPGS
Wikipedia pathwaysFPGS
Orthology - Evolution
OrthoDB2356
GeneTree (enSembl)ENSG00000136877
Phylogenetic Trees/Animal Genes : TreeFamFPGS
HOVERGENQ05932
HOGENOMQ05932
Homologs : HomoloGeneFPGS
Homology/Alignments : Family Browser (UCSC)FPGS
Gene fusions - Rearrangements
Fusion: Tumor Portal FPGS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFPGS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FPGS
dbVarFPGS
ClinVarFPGS
1000_GenomesFPGS 
Exome Variant ServerFPGS
ExAC (Exome Aggregation Consortium)ENSG00000136877
GNOMAD BrowserENSG00000136877
Genetic variants : HAPMAP2356
Genomic Variants (DGV)FPGS [DGVbeta]
DECIPHERFPGS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFPGS 
Mutations
ICGC Data PortalFPGS 
TCGA Data PortalFPGS 
Broad Tumor PortalFPGS
OASIS PortalFPGS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFPGS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFPGS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch FPGS
DgiDB (Drug Gene Interaction Database)FPGS
DoCM (Curated mutations)FPGS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FPGS (select a term)
intoGenFPGS
Cancer3DFPGS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136510   
Orphanet
MedgenFPGS
Genetic Testing Registry FPGS
NextProtQ05932 [Medical]
TSGene2356
GENETestsFPGS
Target ValidationFPGS
Huge Navigator FPGS [HugePedia]
snp3D : Map Gene to Disease2356
BioCentury BCIQFPGS
ClinGenFPGS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2356
Chemical/Pharm GKB GenePA167
Clinical trialFPGS
Miscellaneous
canSAR (ICR)FPGS (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFPGS
EVEXFPGS
GoPubMedFPGS
iHOPFPGS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:50:27 CET 2017

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