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FRK (fyn related Src family tyrosine kinase)

Identity

Alias (NCBI)GTK
PTK5
RAK
HGNC (Hugo) FRK
HGNC Alias symbRAK
GTK
HGNC Previous namePTK5
HGNC Previous namePTK5 protein tyrosine kinase 5
 fyn-related kinase
 fyn-related Src family tyrosine kinase
LocusID (NCBI) 2444
Atlas_Id 528
Location 6q22.1  [Link to chromosome band 6q22]
Location_base_pair Starts at 115931149 and ends at 116060891 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ETV6 (12p13.2)::FRK (6q22.1)FRK (6q22.1)::ABLIM1 (10q25.3)FRK (6q22.1)::DTNBP1 (6p22.3)
FRK (6q22.1)::NT5DC1 (6q22.1)NT5DC1 (6q22.1)::FRK (6q22.1)FRK 6q22.1::DTNBP1 6p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;12)(q22;p13) ETV6::FRK


External links

 

Nomenclature
HGNC (Hugo)FRK   3955
Cards
Entrez_Gene (NCBI)FRK    fyn related Src family tyrosine kinase
AliasesGTK; PTK5; RAK
GeneCards (Weizmann)FRK
Ensembl hg19 (Hinxton)ENSG00000111816 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111816 [Gene_View]  ENSG00000111816 [Sequence]  chr6:115931149-116060891 [Contig_View]  FRK [Vega]
ICGC DataPortalENSG00000111816
TCGA cBioPortalFRK
AceView (NCBI)FRK
Genatlas (Paris)FRK
SOURCE (Princeton)FRK
Genetics Home Reference (NIH)FRK
Genomic and cartography
GoldenPath hg38 (UCSC)FRK  -     chr6:115931149-116060891 -  6q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FRK  -     6q22.1   [Description]    (hg19-Feb_2009)
GoldenPathFRK - 6q22.1 [CytoView hg19]  FRK - 6q22.1 [CytoView hg38]
ImmunoBaseENSG00000111816
Genome Data Viewer NCBIFRK [Mapview hg19]  
OMIM606573   
Gene and transcription
Genbank (Entrez)AK302264 AK313314 BC012916 U00803 U22322
RefSeq transcript (Entrez)NM_002031
Consensus coding sequences : CCDS (NCBI)FRK
Gene ExpressionFRK [ NCBI-GEO ]   FRK [ EBI - ARRAY_EXPRESS ]   FRK [ SEEK ]   FRK [ MEM ]
Gene Expression Viewer (FireBrowse)FRK [ Firebrowse - Broad ]
GenevisibleExpression of FRK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2444
GTEX Portal (Tissue expression)FRK
Human Protein AtlasENSG00000111816-FRK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42685   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42685  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42685
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP42685
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    SH2_Frk    SH3-like_dom_sf    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)PK_Tyr_Ser-Thr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)FRK
SuperfamilyP42685
AlphaFold pdb e-kbP42685   
Human Protein Atlas [tissue]ENSG00000111816-FRK [tissue]
HPRD05954
Protein Interaction databases
DIP (DOE-UCLA)P42685
IntAct (EBI)P42685
BioGRIDFRK
STRING (EMBL)FRK
ZODIACFRK
Ontologies - Pathways
QuickGOP42685
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  extracellular region  intracellular anatomical structure  nucleus  nucleoplasm  cytosol  cytosol  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  negative regulation of cell population proliferation  peptidyl-tyrosine phosphorylation  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  azurophil granule lumen  specific granule lumen  innate immune response  extracellular exosome  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  extracellular region  intracellular anatomical structure  nucleus  nucleoplasm  cytosol  cytosol  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  negative regulation of cell population proliferation  peptidyl-tyrosine phosphorylation  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  azurophil granule lumen  specific granule lumen  innate immune response  extracellular exosome  
NDEx NetworkFRK
Atlas of Cancer Signalling NetworkFRK
Wikipedia pathwaysFRK
Orthology - Evolution
OrthoDB2444
GeneTree (enSembl)ENSG00000111816
Phylogenetic Trees/Animal Genes : TreeFamFRK
Homologs : HomoloGeneFRK
Homology/Alignments : Family Browser (UCSC)FRK
Gene fusions - Rearrangements
Fusion : MitelmanETV6::FRK [12p13.2/6q22.1]  
Fusion : MitelmanFRK::DTNBP1 [6q22.1/6p22.3]  
Fusion : QuiverFRK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFRK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FRK
dbVarFRK
ClinVarFRK
MonarchFRK
1000_GenomesFRK 
Exome Variant ServerFRK
GNOMAD BrowserENSG00000111816
Varsome BrowserFRK
ACMGFRK variants
VarityP42685
Genomic Variants (DGV)FRK [DGVbeta]
DECIPHERFRK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFRK 
Mutations
ICGC Data PortalFRK 
TCGA Data PortalFRK 
Broad Tumor PortalFRK
OASIS PortalFRK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFRK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFRK
Mutations and Diseases : HGMDFRK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFRK
DgiDB (Drug Gene Interaction Database)FRK
DoCM (Curated mutations)FRK
CIViC (Clinical Interpretations of Variants in Cancer)FRK
Cancer3DFRK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606573   
Orphanet
DisGeNETFRK
MedgenFRK
Genetic Testing Registry FRK
NextProtP42685 [Medical]
GENETestsFRK
Target ValidationFRK
Huge Navigator FRK [HugePedia]
ClinGenFRK
Clinical trials, drugs, therapy
MyCancerGenomeFRK
Protein Interactions : CTDFRK
Pharm GKB GenePA28373
PharosP42685
Clinical trialFRK
Miscellaneous
canSAR (ICR)FRK
HarmonizomeFRK
ARCHS4FRK
DataMed IndexFRK
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFRK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:34:10 CET 2022

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