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FRK (fyn related Src family tyrosine kinase)

Identity

Alias_namesPTK5
PTK5 protein tyrosine kinase 5
fyn-related kinase
fyn-related Src family tyrosine kinase
Alias_symbol (synonym)RAK
GTK
Other alias
HGNC (Hugo) FRK
LocusID (NCBI) 2444
Atlas_Id 528
Location 6q22.1  [Link to chromosome band 6q22]
Location_base_pair Starts at 115941530 and ends at 116060758 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ETV6 (12p13.2) / FRK (6q22.1)FRK (6q22.1) / ABLIM1 (10q25.3)FRK (6q22.1) / DTNBP1 (6p22.3)
FRK (6q22.1) / NT5DC1 (6q22.1)NT5DC1 (6q22.1) / FRK (6q22.1)FRK 6q22.1 / DTNBP1 6p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;12)(q21-22;p13) FRK/ETV6
t(6;12)(q22;p13) ETV6/FRK


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p22;q22) FRK/DTNBP1


External links

Nomenclature
HGNC (Hugo)FRK   3955
Cards
Entrez_Gene (NCBI)FRK  2444  fyn related Src family tyrosine kinase
AliasesGTK; PTK5; RAK
GeneCards (Weizmann)FRK
Ensembl hg19 (Hinxton)ENSG00000111816 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111816 [Gene_View]  ENSG00000111816 [Sequence]  chr6:115941530-116060758 [Contig_View]  FRK [Vega]
ICGC DataPortalENSG00000111816
TCGA cBioPortalFRK
AceView (NCBI)FRK
Genatlas (Paris)FRK
WikiGenes2444
SOURCE (Princeton)FRK
Genetics Home Reference (NIH)FRK
Genomic and cartography
GoldenPath hg38 (UCSC)FRK  -     chr6:115941530-116060758 -  6q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FRK  -     6q22.1   [Description]    (hg19-Feb_2009)
EnsemblFRK - 6q22.1 [CytoView hg19]  FRK - 6q22.1 [CytoView hg38]
Mapping of homologs : NCBIFRK [Mapview hg19]  FRK [Mapview hg38]
OMIM606573   
Gene and transcription
Genbank (Entrez)AK302264 AK313314 BC012916 U00803 U22322
RefSeq transcript (Entrez)NM_002031
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FRK
Cluster EST : UnigeneHs.89426 [ NCBI ]
CGAP (NCI)Hs.89426
Alternative Splicing GalleryENSG00000111816
Gene ExpressionFRK [ NCBI-GEO ]   FRK [ EBI - ARRAY_EXPRESS ]   FRK [ SEEK ]   FRK [ MEM ]
Gene Expression Viewer (FireBrowse)FRK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2444
GTEX Portal (Tissue expression)FRK
Human Protein AtlasENSG00000111816-FRK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42685   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42685  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42685
Splice isoforms : SwissVarP42685
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusP42685
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    SH2_Frk    SH3-like_dom_sf    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)FRK
DMDM Disease mutations2444
Blocks (Seattle)FRK
SuperfamilyP42685
Human Protein Atlas [tissue]ENSG00000111816-FRK [tissue]
Peptide AtlasP42685
HPRD05954
IPIIPI00000885   IPI01011572   
Protein Interaction databases
DIP (DOE-UCLA)P42685
IntAct (EBI)P42685
FunCoupENSG00000111816
BioGRIDFRK
STRING (EMBL)FRK
ZODIACFRK
Ontologies - Pathways
QuickGOP42685
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  extracellular region  intracellular  nucleus  cytosol  cytosol  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  negative regulation of cell proliferation  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  azurophil granule lumen  specific granule lumen  peptidyl-tyrosine autophosphorylation  neutrophil degranulation  extracellular exosome  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  extracellular region  intracellular  nucleus  cytosol  cytosol  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  negative regulation of cell proliferation  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  azurophil granule lumen  specific granule lumen  peptidyl-tyrosine autophosphorylation  neutrophil degranulation  extracellular exosome  
NDEx NetworkFRK
Atlas of Cancer Signalling NetworkFRK
Wikipedia pathwaysFRK
Orthology - Evolution
OrthoDB2444
GeneTree (enSembl)ENSG00000111816
Phylogenetic Trees/Animal Genes : TreeFamFRK
HOVERGENP42685
HOGENOMP42685
Homologs : HomoloGeneFRK
Homology/Alignments : Family Browser (UCSC)FRK
Gene fusions - Rearrangements
Fusion : MitelmanETV6/FRK [12p13.2/6q22.1]  [t(6;12)(q22;p13)]  
Fusion : MitelmanFRK/DTNBP1 [6q22.1/6p22.3]  [t(6;6)(p22;q22)]  
Fusion PortalFRK 6q22.1 DTNBP1 6p22.3 BRCA
Fusion : QuiverFRK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFRK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FRK
dbVarFRK
ClinVarFRK
1000_GenomesFRK 
Exome Variant ServerFRK
ExAC (Exome Aggregation Consortium)ENSG00000111816
GNOMAD BrowserENSG00000111816
Varsome BrowserFRK
Genetic variants : HAPMAP2444
Genomic Variants (DGV)FRK [DGVbeta]
DECIPHERFRK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFRK 
Mutations
ICGC Data PortalFRK 
TCGA Data PortalFRK 
Broad Tumor PortalFRK
OASIS PortalFRK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFRK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFRK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FRK
DgiDB (Drug Gene Interaction Database)FRK
DoCM (Curated mutations)FRK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FRK (select a term)
intoGenFRK
Cancer3DFRK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606573   
Orphanet
DisGeNETFRK
MedgenFRK
Genetic Testing Registry FRK
NextProtP42685 [Medical]
TSGene2444
GENETestsFRK
Target ValidationFRK
Huge Navigator FRK [HugePedia]
snp3D : Map Gene to Disease2444
BioCentury BCIQFRK
ClinGenFRK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2444
Chemical/Pharm GKB GenePA28373
Clinical trialFRK
Miscellaneous
canSAR (ICR)FRK (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFRK
EVEXFRK
GoPubMedFRK
iHOPFRK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:07:17 CET 2018

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