FRK (fyn related Src family tyrosine kinase)

2003-11-01  

Identity

HGNC
LOCATION
6q22.1
LOCUSID
ALIAS
GTK,PTK5,RAK
FUSION GENES

Other Information

Locus ID:

NCBI: 2444
MIM: 606573
HGNC: 3955
Ensembl: ENSG00000111816

Variants:

dbSNP: 2444
ClinVar: 2444
TCGA: ENSG00000111816
COSMIC: FRK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111816ENST00000606080P42685

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
216659902011Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.112
193453292009Rak functions as a tumor suppressor by regulating PTEN protein stability and function.65
247359222014Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.58
232671732013In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma.57
127255322003Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.46
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
125695672003Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase.10
227904442012FRK controls migration and invasion of human glioma cells by regulating JNK/c-Jun signaling.10
249693242015FRK inhibits migration and invasion of human glioma cells by promoting N-cadherin/β-catenin complex formation.8
247924912014FRK suppresses the proliferation of human glioma cells by inhibiting cyclin D1 nuclear accumulation.6

Citation

Dessen P

FRK (fyn related Src family tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/528/frk