Atlas of Genetics and Cytogenetics in Oncology and Haematology


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G6PD (glucose-6-phosphate dehydrogenase)

Identity

Other namesG6PD1
HGNC (Hugo) G6PD
LocusID (NCBI) 2539
Location Xq28
Location_base_pair Starts at 153759605 and ends at 153775233 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors ProstateOverviewID5041

External links

Nomenclature
HGNC (Hugo)G6PD   4057
Cards
Entrez_Gene (NCBI)G6PD  2539  glucose-6-phosphate dehydrogenase
GeneCards (Weizmann)G6PD
Ensembl (Hinxton)ENSG00000160211 [Gene_View]  chrX:153759605-153775233 [Contig_View]  G6PD [Vega]
ICGC DataPortalENSG00000160211
cBioPortalG6PD
AceView (NCBI)G6PD
Genatlas (Paris)G6PD
WikiGenes2539
SOURCE (Princeton)NM_000402 NM_001042351
Genomic and cartography
GoldenPath (UCSC)G6PD  -  Xq28   chrX:153759605-153775233 -  Xq28   [Description]    (hg19-Feb_2009)
EnsemblG6PD - Xq28 [CytoView]
Mapping of homologs : NCBIG6PD [Mapview]
OMIM134700   300908   305900   611162   
Gene and transcription
Genbank (Entrez)AK292304 AK302341 AL560686 BC000337 BU589629
RefSeq transcript (Entrez)NM_000402 NM_001042351
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_009015 NT_011681 NW_001842419 NW_004929448
Consensus coding sequences : CCDS (NCBI)G6PD
Cluster EST : UnigeneHs.684904 [ NCBI ]
CGAP (NCI)Hs.684904
Alternative Splicing : Fast-db (Paris)GSHG0032441
Alternative Splicing GalleryENSG00000160211
Gene ExpressionG6PD [ NCBI-GEO ]     G6PD [ SEEK ]   G6PD [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11413 (Uniprot)
NextProtP11413  [Medical]
With graphics : InterProP11413
Splice isoforms : SwissVarP11413 (Swissvar)
Domaine pattern : Prosite (Expaxy)G6P_DEHYDROGENASE (PS00069)   
Domains : Interpro (EBI)G6P_DH [organisation]   G6P_DH_AS [organisation]   G6P_DH_C [organisation]   G6P_DH_NAD-bd [organisation]   NAD(P)-bd_dom [organisation]  
Related proteins : CluSTrP11413
Domain families : Pfam (Sanger)G6PD_C (PF02781)    G6PD_N (PF00479)   
Domain families : Pfam (NCBI)pfam02781    pfam00479   
DMDM Disease mutations2539
Blocks (Seattle)P11413
PDB (SRS)1QKI    2BH9    2BHL   
PDB (PDBSum)1QKI    2BH9    2BHL   
PDB (IMB)1QKI    2BH9    2BHL   
PDB (RSDB)1QKI    2BH9    2BHL   
Human Protein AtlasENSG00000160211 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP11413
HPRD02377
IPIIPI00289800   IPI00216008   IPI00853547   IPI00884082   IPI00642620   IPI00645745   
Protein Interaction databases
DIP (DOE-UCLA)P11413
IntAct (EBI)P11413
FunCoupENSG00000160211
BioGRIDG6PD
InParanoidP11413
Interologous Interaction database P11413
IntegromeDBG6PD
STRING (EMBL)G6PD
Ontologies - Pathways
Ontology : AmiGOcytokine production  glucose-6-phosphate dehydrogenase activity  glucose-6-phosphate dehydrogenase activity  protein binding  glucose binding  glucose binding  nucleus  cytoplasm  cytosol  cytosol  carbohydrate metabolic process  pentose-phosphate shunt  pentose-phosphate shunt  lipid metabolic process  cholesterol biosynthetic process  NADP metabolic process  NADPH regeneration  glutathione metabolic process  pentose-phosphate shunt, oxidative branch  cytoplasmic side of plasma membrane  negative regulation of protein glutathionylation  response to organic cyclic compound  membrane  pentose biosynthetic process  substantia nigra development  response to food  cellular response to oxidative stress  protein homodimerization activity  erythrocyte maturation  regulation of neuron apoptotic process  small molecule metabolic process  response to ethanol  ribose phosphate biosynthetic process  NADP binding  glucose 6-phosphate metabolic process  glucose 6-phosphate metabolic process  oxidation-reduction process  extracellular vesicular exosome  
Ontology : EGO-EBIcytokine production  glucose-6-phosphate dehydrogenase activity  glucose-6-phosphate dehydrogenase activity  protein binding  glucose binding  glucose binding  nucleus  cytoplasm  cytosol  cytosol  carbohydrate metabolic process  pentose-phosphate shunt  pentose-phosphate shunt  lipid metabolic process  cholesterol biosynthetic process  NADP metabolic process  NADPH regeneration  glutathione metabolic process  pentose-phosphate shunt, oxidative branch  cytoplasmic side of plasma membrane  negative regulation of protein glutathionylation  response to organic cyclic compound  membrane  pentose biosynthetic process  substantia nigra development  response to food  cellular response to oxidative stress  protein homodimerization activity  erythrocyte maturation  regulation of neuron apoptotic process  small molecule metabolic process  response to ethanol  ribose phosphate biosynthetic process  NADP binding  glucose 6-phosphate metabolic process  glucose 6-phosphate metabolic process  oxidation-reduction process  extracellular vesicular exosome  
Pathways : KEGGPentose phosphate pathway    Glutathione metabolism   
Protein Interaction DatabaseG6PD
Wikipedia pathwaysG6PD
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)G6PD
snp3D : Map Gene to Disease2539
SNP (GeneSNP Utah)G6PD
SNP : HGBaseG6PD
Genetic variants : HAPMAPG6PD
Exome VariantG6PD
1000_GenomesG6PD 
ICGC programENSG00000160211 
Somatic Mutations in Cancer : COSMICG6PD 
CONAN: Copy Number AnalysisG6PD 
Mutations and Diseases : HGMDG6PD
Genomic VariantsG6PD  G6PD [DGVbeta]
dbVarG6PD
ClinVarG6PD
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM134700    300908    305900    611162   
MedgenG6PD
GENETestsG6PD
Disease Genetic AssociationG6PD
Huge Navigator G6PD [HugePedia]  G6PD [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneG6PD
Homology/Alignments : Family Browser (UCSC)G6PD
Phylogenetic Trees/Animal Genes : TreeFamG6PD
Chemical/Protein Interactions : CTD2539
Chemical/Pharm GKB GenePA28469
Clinical trialG6PD
Cancer Resource (Charite)ENSG00000160211
Other databases
Probes
Litterature
PubMed273 Pubmed reference(s) in Entrez
CoreMineG6PD
iHOPG6PD
OncoSearchG6PD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:55:37 CEST 2014

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