Atlas of Genetics and Cytogenetics in Oncology and Haematology


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G6PD (glucose-6-phosphate dehydrogenase)

Identity

Other namesG6PD1
HGNC (Hugo) G6PD
LocusID (NCBI) 2539
Atlas_Id 40662
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 153759605 and ends at 153775233 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANAPC5 (12q24.31) / G6PD (Xq28)G6PD (Xq28) / F8 (Xq28)G6PD (Xq28) / G6PD (Xq28)
G6PD (Xq28) / IKBKG (Xq28)G6PD (Xq28) / PRKCA (17q24.2)G6PD Xq28 / F8 Xq28

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Uterus: Leiomyoma

External links

Nomenclature
HGNC (Hugo)G6PD   4057
Cards
Entrez_Gene (NCBI)G6PD  2539  glucose-6-phosphate dehydrogenase
AliasesG6PD1
GeneCards (Weizmann)G6PD
Ensembl hg19 (Hinxton)ENSG00000160211 [Gene_View]  chrX:153759605-153775233 [Contig_View]  G6PD [Vega]
Ensembl hg38 (Hinxton)ENSG00000160211 [Gene_View]  chrX:153759605-153775233 [Contig_View]  G6PD [Vega]
ICGC DataPortalENSG00000160211
TCGA cBioPortalG6PD
AceView (NCBI)G6PD
Genatlas (Paris)G6PD
WikiGenes2539
SOURCE (Princeton)G6PD
Genomic and cartography
GoldenPath hg19 (UCSC)G6PD  -     chrX:153759605-153775233 -  Xq28   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)G6PD  -     Xq28   [Description]    (hg38-Dec_2013)
EnsemblG6PD - Xq28 [CytoView hg19]  G6PD - Xq28 [CytoView hg38]
Mapping of homologs : NCBIG6PD [Mapview hg19]  G6PD [Mapview hg38]
OMIM134700   300908   305900   611162   
Gene and transcription
Genbank (Entrez)AK292304 AK302341 AL560686 BC000337 BU589629
RefSeq transcript (Entrez)NM_000402 NM_001042351
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_009015 NT_011681 NW_004929448
Consensus coding sequences : CCDS (NCBI)G6PD
Cluster EST : UnigeneHs.684904 [ NCBI ]
CGAP (NCI)Hs.684904
Alternative Splicing GalleryENSG00000160211
Gene ExpressionG6PD [ NCBI-GEO ]   G6PD [ EBI - ARRAY_EXPRESS ]   G6PD [ SEEK ]   G6PD [ MEM ]
Gene Expression Viewer (FireBrowse)G6PD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2539
GTEX Portal (Tissue expression)G6PD
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11413 (Uniprot)
NextProtP11413  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11413
Splice isoforms : SwissVarP11413 (Swissvar)
PhosPhoSitePlusP11413
Domaine pattern : Prosite (Expaxy)G6P_DEHYDROGENASE (PS00069)   
Domains : Interpro (EBI)G6P_DH    G6P_DH_AS    G6P_DH_C    G6P_DH_NAD-bd    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)G6PD_C (PF02781)    G6PD_N (PF00479)   
Domain families : Pfam (NCBI)pfam02781    pfam00479   
DMDM Disease mutations2539
Blocks (Seattle)G6PD
PDB (SRS)1QKI    2BH9    2BHL   
PDB (PDBSum)1QKI    2BH9    2BHL   
PDB (IMB)1QKI    2BH9    2BHL   
PDB (RSDB)1QKI    2BH9    2BHL   
Structural Biology KnowledgeBase1QKI    2BH9    2BHL   
SCOP (Structural Classification of Proteins)1QKI    2BH9    2BHL   
CATH (Classification of proteins structures)1QKI    2BH9    2BHL   
SuperfamilyP11413
Human Protein AtlasENSG00000160211
Peptide AtlasP11413
HPRD02377
IPIIPI00289800   IPI00216008   IPI00853547   IPI00884082   IPI00642620   IPI00645745   
Protein Interaction databases
DIP (DOE-UCLA)P11413
IntAct (EBI)P11413
FunCoupENSG00000160211
BioGRIDG6PD
STRING (EMBL)G6PD
ZODIACG6PD
Ontologies - Pathways
QuickGOP11413
Ontology : AmiGOglucose-6-phosphate dehydrogenase activity  glucose-6-phosphate dehydrogenase activity  glucose-6-phosphate dehydrogenase activity  protein binding  glucose binding  glucose binding  nucleus  cytoplasm  centrosome  microtubule organizing center  cytosol  cytosol  glucose metabolic process  pentose-phosphate shunt  pentose-phosphate shunt  lipid metabolic process  cholesterol biosynthetic process  NADP metabolic process  NADPH regeneration  glutathione metabolic process  pentose-phosphate shunt, oxidative branch  cytoplasmic side of plasma membrane  negative regulation of protein glutathionylation  response to organic cyclic compound  membrane  pentose biosynthetic process  substantia nigra development  response to food  cellular response to oxidative stress  identical protein binding  protein homodimerization activity  intracellular membrane-bounded organelle  erythrocyte maturation  regulation of neuron apoptotic process  response to ethanol  ribose phosphate biosynthetic process  NADP binding  glucose 6-phosphate metabolic process  glucose 6-phosphate metabolic process  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIglucose-6-phosphate dehydrogenase activity  glucose-6-phosphate dehydrogenase activity  glucose-6-phosphate dehydrogenase activity  protein binding  glucose binding  glucose binding  nucleus  cytoplasm  centrosome  microtubule organizing center  cytosol  cytosol  glucose metabolic process  pentose-phosphate shunt  pentose-phosphate shunt  lipid metabolic process  cholesterol biosynthetic process  NADP metabolic process  NADPH regeneration  glutathione metabolic process  pentose-phosphate shunt, oxidative branch  cytoplasmic side of plasma membrane  negative regulation of protein glutathionylation  response to organic cyclic compound  membrane  pentose biosynthetic process  substantia nigra development  response to food  cellular response to oxidative stress  identical protein binding  protein homodimerization activity  intracellular membrane-bounded organelle  erythrocyte maturation  regulation of neuron apoptotic process  response to ethanol  ribose phosphate biosynthetic process  NADP binding  glucose 6-phosphate metabolic process  glucose 6-phosphate metabolic process  oxidation-reduction process  extracellular exosome  
Pathways : KEGGPentose phosphate pathway    Glutathione metabolism   
NDEx Network
Atlas of Cancer Signalling NetworkG6PD
Wikipedia pathwaysG6PD
Orthology - Evolution
OrthoDB2539
GeneTree (enSembl)ENSG00000160211
Phylogenetic Trees/Animal Genes : TreeFamG6PD
Homologs : HomoloGeneG6PD
Homology/Alignments : Family Browser (UCSC)G6PD
Gene fusions - Rearrangements
Fusion: TCGAG6PD Xq28 F8 Xq28 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerG6PD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)G6PD
dbVarG6PD
ClinVarG6PD
1000_GenomesG6PD 
Exome Variant ServerG6PD
ExAC (Exome Aggregation Consortium)G6PD (select the gene name)
Genetic variants : HAPMAP2539
Genomic Variants (DGV)G6PD [DGVbeta]
Mutations
ICGC Data PortalG6PD 
TCGA Data PortalG6PD 
Broad Tumor PortalG6PD
OASIS PortalG6PD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICG6PD 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch G6PD
DgiDB (Drug Gene Interaction Database)G6PD
DoCM (Curated mutations)G6PD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)G6PD (select a term)
intoGenG6PD
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:153759605-153775233  ENSG00000160211
CONAN: Copy Number AnalysisG6PD 
Mutations and Diseases : HGMDG6PD
OMIM134700    300908    305900    611162   
MedgenG6PD
Genetic Testing Registry G6PD
NextProtP11413 [Medical]
TSGene2539
GENETestsG6PD
Huge Navigator G6PD [HugePedia]
snp3D : Map Gene to Disease2539
BioCentury BCIQG6PD
ClinGenG6PD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2539
Chemical/Pharm GKB GenePA28469
Clinical trialG6PD
Miscellaneous
canSAR (ICR)G6PD (select the gene name)
Probes
Litterature
PubMed295 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineG6PD
EVEXG6PD
GoPubMedG6PD
iHOPG6PD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:02:50 CEST 2016

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