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GABPA (GA binding protein transcription factor alpha subunit)

Identity

Alias_namesGA-binding protein transcription factor, alpha subunit (60kD)
GA binding protein transcription factor, alpha subunit 60kDa
Alias_symbol (synonym)E4TF1A
NFT2
NRF2
E4TF1-60
NRF2A
Other aliasRCH04A07
HGNC (Hugo) GABPA
LocusID (NCBI) 2551
Atlas_Id 45863
Location 21q21.3  [Link to chromosome band 21q21]
Location_base_pair Starts at 27107258 and ends at 27144771 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GABPA (21q21.3) / ALB (4q13.3)GABPA (21q21.3) / OPCML (11q25)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GABPA   4071
Cards
Entrez_Gene (NCBI)GABPA  2551  GA binding protein transcription factor alpha subunit
AliasesE4TF1-60; E4TF1A; NFT2; NRF2; 
NRF2A; RCH04A07
GeneCards (Weizmann)GABPA
Ensembl hg19 (Hinxton)ENSG00000154727 [Gene_View]  chr21:27107258-27144771 [Contig_View]  GABPA [Vega]
Ensembl hg38 (Hinxton)ENSG00000154727 [Gene_View]  chr21:27107258-27144771 [Contig_View]  GABPA [Vega]
ICGC DataPortalENSG00000154727
TCGA cBioPortalGABPA
AceView (NCBI)GABPA
Genatlas (Paris)GABPA
WikiGenes2551
SOURCE (Princeton)GABPA
Genetics Home Reference (NIH)GABPA
Genomic and cartography
GoldenPath hg19 (UCSC)GABPA  -     chr21:27107258-27144771 +  21q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GABPA  -     21q21.3   [Description]    (hg38-Dec_2013)
EnsemblGABPA - 21q21.3 [CytoView hg19]  GABPA - 21q21.3 [CytoView hg38]
Mapping of homologs : NCBIGABPA [Mapview hg19]  GABPA [Mapview hg38]
OMIM600609   
Gene and transcription
Genbank (Entrez)AI917898 AK223164 AK313545 BC035031 BG542623
RefSeq transcript (Entrez)NM_001197297 NM_002040
RefSeq genomic (Entrez)NC_000021 NC_018932 NT_011512 NW_004929426
Consensus coding sequences : CCDS (NCBI)GABPA
Cluster EST : UnigeneHs.473470 [ NCBI ]
CGAP (NCI)Hs.473470
Alternative Splicing GalleryENSG00000154727
Gene ExpressionGABPA [ NCBI-GEO ]   GABPA [ EBI - ARRAY_EXPRESS ]   GABPA [ SEEK ]   GABPA [ MEM ]
Gene Expression Viewer (FireBrowse)GABPA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2551
GTEX Portal (Tissue expression)GABPA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ06546   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ06546  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ06546
Splice isoforms : SwissVarQ06546
PhosPhoSitePlusQ06546
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)    PNT (PS51433)   
Domains : Interpro (EBI)Ets_dom    GABP_asu_N    Pointed_dom    SAM/pointed    TF_GA-bd_asu    Ubiquitin-rel_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Ets (PF00178)    GABP-alpha (PF11620)    SAM_PNT (PF02198)   
Domain families : Pfam (NCBI)pfam00178    pfam11620    pfam02198   
Domain families : Smart (EMBL)ETS (SM00413)  SAM_PNT (SM00251)  
Conserved Domain (NCBI)GABPA
DMDM Disease mutations2551
Blocks (Seattle)GABPA
SuperfamilyQ06546
Human Protein AtlasENSG00000154727
Peptide AtlasQ06546
HPRD11793
IPIIPI00299413   
Protein Interaction databases
DIP (DOE-UCLA)Q06546
IntAct (EBI)Q06546
FunCoupENSG00000154727
BioGRIDGABPA
STRING (EMBL)GABPA
ZODIACGABPA
Ontologies - Pathways
QuickGOQ06546
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  in utero embryonic development  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription from RNA polymerase II promoter  mitochondrion organization  cell differentiation  transcription regulatory region DNA binding  negative regulation of megakaryocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  in utero embryonic development  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription from RNA polymerase II promoter  mitochondrion organization  cell differentiation  transcription regulatory region DNA binding  negative regulation of megakaryocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  
NDEx NetworkGABPA
Atlas of Cancer Signalling NetworkGABPA
Wikipedia pathwaysGABPA
Orthology - Evolution
OrthoDB2551
GeneTree (enSembl)ENSG00000154727
Phylogenetic Trees/Animal Genes : TreeFamGABPA
HOVERGENQ06546
HOGENOMQ06546
Homologs : HomoloGeneGABPA
Homology/Alignments : Family Browser (UCSC)GABPA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGABPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GABPA
dbVarGABPA
ClinVarGABPA
1000_GenomesGABPA 
Exome Variant ServerGABPA
ExAC (Exome Aggregation Consortium)GABPA (select the gene name)
Genetic variants : HAPMAP2551
Genomic Variants (DGV)GABPA [DGVbeta]
DECIPHER (Syndromes)21:27107258-27144771  ENSG00000154727
CONAN: Copy Number AnalysisGABPA 
Mutations
ICGC Data PortalGABPA 
TCGA Data PortalGABPA 
Broad Tumor PortalGABPA
OASIS PortalGABPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGABPA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGABPA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GABPA
DgiDB (Drug Gene Interaction Database)GABPA
DoCM (Curated mutations)GABPA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GABPA (select a term)
intoGenGABPA
Cancer3DGABPA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600609   
Orphanet
MedgenGABPA
Genetic Testing Registry GABPA
NextProtQ06546 [Medical]
TSGene2551
GENETestsGABPA
Huge Navigator GABPA [HugePedia]
snp3D : Map Gene to Disease2551
BioCentury BCIQGABPA
ClinGenGABPA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2551
Chemical/Pharm GKB GenePA28485
Clinical trialGABPA
Miscellaneous
canSAR (ICR)GABPA (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGABPA
EVEXGABPA
GoPubMedGABPA
iHOPGABPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:06:52 CET 2017

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