GALR2 (galanin receptor 2)

2007-02-01  

Identity

HGNC
GALR2
LOCATION
17q25.1
LOCUSID
8811
ALIAS
GAL2-R,GALNR2,GALR-2

Other Information

Locus ID:

NCBI: 8811
MIM: 603691
HGNC: 4133
Ensembl: ENSG00000182687

Variants:

dbSNP: 8811
ClinVar: 8811
TCGA: ENSG00000182687
COSMIC: GALR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182687ENST00000329003O43603

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
245172312014Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.32
247068712014Brain galanin system genes interact with life stresses in depression-related phenotypes.28
170833332007Alcoholism is associated with GALR3 but not two other galanin receptor genes.24
170833332007Alcoholism is associated with GALR3 but not two other galanin receptor genes.24
241224502014Tumor suppressor activity and inactivation of galanin receptor type 2 by aberrant promoter methylation in head and neck cancer.17
145929622004Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells.13
182724872008Galanin decreases proliferation of PC12 cells and induces apoptosis via its subtype 2 receptor (GalR2).13
213453692011Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma.13
245689682014The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer.11

Citation

Dessen P

GALR2 (galanin receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45716/galr2