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GCLM (glutamate-cysteine ligase modifier subunit)

Identity

Alias_namesGLCLR
glutamate-cysteine ligase
Other alias
HGNC (Hugo) GCLM
LocusID (NCBI) 2730
Atlas_Id 43938
Location 1p22.1  [Link to chromosome band 1p22]
Location_base_pair Starts at 93885200 and ends at 93909598 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNTTIP2 (1p22.1) / GCLM (1p22.1)SAMD9 (7q21.2) / GCLM (1p22.1)SNTG2 (2p25.3) / GCLM (1p22.1)
DNTTIP2 1p22.1 / GCLM 1p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GCLM   4312
Cards
Entrez_Gene (NCBI)GCLM  2730  glutamate-cysteine ligase modifier subunit
AliasesGLCLR
GeneCards (Weizmann)GCLM
Ensembl hg19 (Hinxton)ENSG00000023909 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000023909 [Gene_View]  chr1:93885200-93909598 [Contig_View]  GCLM [Vega]
ICGC DataPortalENSG00000023909
TCGA cBioPortalGCLM
AceView (NCBI)GCLM
Genatlas (Paris)GCLM
WikiGenes2730
SOURCE (Princeton)GCLM
Genetics Home Reference (NIH)GCLM
Genomic and cartography
GoldenPath hg38 (UCSC)GCLM  -     chr1:93885200-93909598 -  1p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GCLM  -     1p22.1   [Description]    (hg19-Feb_2009)
EnsemblGCLM - 1p22.1 [CytoView hg19]  GCLM - 1p22.1 [CytoView hg38]
Mapping of homologs : NCBIGCLM [Mapview hg19]  GCLM [Mapview hg38]
OMIM601176   608446   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001308253 NM_002061
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GCLM
Cluster EST : UnigeneHs.711318 [ NCBI ]
CGAP (NCI)Hs.711318
Alternative Splicing GalleryENSG00000023909
Gene ExpressionGCLM [ NCBI-GEO ]   GCLM [ EBI - ARRAY_EXPRESS ]   GCLM [ SEEK ]   GCLM [ MEM ]
Gene Expression Viewer (FireBrowse)GCLM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2730
GTEX Portal (Tissue expression)GCLM
Human Protein AtlasENSG00000023909-GCLM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48507   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48507  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48507
Splice isoforms : SwissVarP48507
PhosPhoSitePlusP48507
Domains : Interpro (EBI)Gclm    NADP_OxRdtase_dom   
Domain families : Pfam (Sanger)Aldo_ket_red (PF00248)   
Domain families : Pfam (NCBI)pfam00248   
Conserved Domain (NCBI)GCLM
DMDM Disease mutations2730
Blocks (Seattle)GCLM
SuperfamilyP48507
Human Protein Atlas [tissue]ENSG00000023909-GCLM [tissue]
Peptide AtlasP48507
HPRD03106
IPIIPI00010090   IPI00956063   
Protein Interaction databases
DIP (DOE-UCLA)P48507
IntAct (EBI)P48507
FunCoupENSG00000023909
BioGRIDGCLM
STRING (EMBL)GCLM
ZODIACGCLM
Ontologies - Pathways
QuickGOP48507
Ontology : AmiGOsulfur amino acid metabolic process  glutamate-cysteine ligase activity  glutamate-cysteine ligase activity  cytosol  cytosol  cysteine metabolic process  glutamate metabolic process  glutathione biosynthetic process  glutathione biosynthetic process  glutathione biosynthetic process  glutathione biosynthetic process  response to oxidative stress  aging  response to nutrient  apoptotic mitochondrial changes  response to activity  glutamate-cysteine ligase complex  enzyme regulator activity  glutamate-cysteine ligase catalytic subunit binding  positive regulation of glutamate-cysteine ligase activity  cellular response to hepatocyte growth factor stimulus  hepatic stellate cell activation  response to drug  negative regulation of neuron apoptotic process  cellular response to fibroblast growth factor stimulus  response to human chorionic gonadotropin  protein heterodimerization activity  regulation of blood vessel size  response to nitrosative stress  regulation of mitochondrial depolarization  cellular response to glucose stimulus  cellular response to follicle-stimulating hormone stimulus  cellular response to thyroxine stimulus  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIsulfur amino acid metabolic process  glutamate-cysteine ligase activity  glutamate-cysteine ligase activity  cytosol  cytosol  cysteine metabolic process  glutamate metabolic process  glutathione biosynthetic process  glutathione biosynthetic process  glutathione biosynthetic process  glutathione biosynthetic process  response to oxidative stress  aging  response to nutrient  apoptotic mitochondrial changes  response to activity  glutamate-cysteine ligase complex  enzyme regulator activity  glutamate-cysteine ligase catalytic subunit binding  positive regulation of glutamate-cysteine ligase activity  cellular response to hepatocyte growth factor stimulus  hepatic stellate cell activation  response to drug  negative regulation of neuron apoptotic process  cellular response to fibroblast growth factor stimulus  response to human chorionic gonadotropin  protein heterodimerization activity  regulation of blood vessel size  response to nitrosative stress  regulation of mitochondrial depolarization  cellular response to glucose stimulus  cellular response to follicle-stimulating hormone stimulus  cellular response to thyroxine stimulus  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGGlutathione metabolism   
NDEx NetworkGCLM
Atlas of Cancer Signalling NetworkGCLM
Wikipedia pathwaysGCLM
Orthology - Evolution
OrthoDB2730
GeneTree (enSembl)ENSG00000023909
Phylogenetic Trees/Animal Genes : TreeFamGCLM
HOVERGENP48507
HOGENOMP48507
Homologs : HomoloGeneGCLM
Homology/Alignments : Family Browser (UCSC)GCLM
Gene fusions - Rearrangements
Fusion : MitelmanDNTTIP2/GCLM [1p22.1/1p22.1]  [t(1;1)(p22;p22)]  
Fusion: TCGA_MDACCDNTTIP2 1p22.1 GCLM 1p22.1 BRCA
Tumor Fusion PortalGCLM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGCLM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GCLM
dbVarGCLM
ClinVarGCLM
1000_GenomesGCLM 
Exome Variant ServerGCLM
ExAC (Exome Aggregation Consortium)ENSG00000023909
GNOMAD BrowserENSG00000023909
Genetic variants : HAPMAP2730
Genomic Variants (DGV)GCLM [DGVbeta]
DECIPHERGCLM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGCLM 
Mutations
ICGC Data PortalGCLM 
TCGA Data PortalGCLM 
Broad Tumor PortalGCLM
OASIS PortalGCLM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGCLM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGCLM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GCLM
DgiDB (Drug Gene Interaction Database)GCLM
DoCM (Curated mutations)GCLM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GCLM (select a term)
intoGenGCLM
Cancer3DGCLM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601176    608446   
Orphanet
DisGeNETGCLM
MedgenGCLM
Genetic Testing Registry GCLM
NextProtP48507 [Medical]
TSGene2730
GENETestsGCLM
Target ValidationGCLM
Huge Navigator GCLM [HugePedia]
snp3D : Map Gene to Disease2730
BioCentury BCIQGCLM
ClinGenGCLM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2730
Chemical/Pharm GKB GenePA28613
Clinical trialGCLM
Miscellaneous
canSAR (ICR)GCLM (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGCLM
EVEXGCLM
GoPubMedGCLM
iHOPGCLM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:14:21 CET 2017

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