GCLM (glutamate-cysteine ligase modifier subunit)

2007-02-01 Affiliation

Identity

HGNC

GCLM

LOCATION

1p22.1

LOCUSID

2730

ALIAS

GLCLR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2730
MIM: 601176
HGNC: 4312
Ensembl: ENSG00000023909

Variants:

dbSNP: 2730
ClinVar: 2730
TCGA: ENSG00000023909
COSMIC: GCLM

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000023909	ENST00000370238	P48507
ENSG00000023909	ENST00000615724	P48507

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Glutathione metabolism	KEGG	hsa00480
Cysteine and methionine metabolism	KEGG	ko00270
Cysteine and methionine metabolism	KEGG	hsa00270
Metabolic pathways	KEGG	hsa01100
Glutathione biosynthesis, glutamate => glutathione	KEGG	hsa_M00118
Glutathione biosynthesis, glutamate => glutathione	KEGG	M00118
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Sulfur amino acid metabolism	REACTOME	R-HSA-1614635
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glutathione conjugation	REACTOME	R-HSA-156590
Glutathione synthesis and recycling	REACTOME	R-HSA-174403
Ferroptosis	KEGG	ko04216
Ferroptosis	KEGG	hsa04216

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16081425	2005	Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.	78
19808663	2009	Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid.	71
16909399	2006	Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.	65
21555518	2011	The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.	60
15451055	2004	Human glutamate cysteine ligase gene regulation through the electrophile response element.	55
12081989	2002	Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.	48
12081989	2002	Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.	48
18560528	2008	Genetic variation in glutathione-related genes and body burden of methylmercury.	33
16599007	2004	Polymorphisms in glutathione-related genes affect methylmercury retention.	29

Citation

Dessen P

GCLM (glutamate-cysteine ligase modifier subunit)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43938/gclm