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GDF7 (growth differentiation factor 7)

Identity

Alias_symbol (synonym)BMP12
Other alias
HGNC (Hugo) GDF7
LocusID (NCBI) 151449
Atlas_Id 46990
Location 2p24.1  [Link to chromosome band 2p24]
Location_base_pair Starts at 20866424 and ends at 20871250 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GDF7   4222
Cards
Entrez_Gene (NCBI)GDF7  151449  growth differentiation factor 7
AliasesBMP12
GeneCards (Weizmann)GDF7
Ensembl hg19 (Hinxton)ENSG00000143869 [Gene_View]  chr2:20866424-20871250 [Contig_View]  GDF7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000143869 [Gene_View]  chr2:20866424-20871250 [Contig_View]  GDF7 [Vega]
ICGC DataPortalENSG00000143869
TCGA cBioPortalGDF7
AceView (NCBI)GDF7
Genatlas (Paris)GDF7
WikiGenes151449
SOURCE (Princeton)GDF7
Genetics Home Reference (NIH)GDF7
Genomic and cartography
GoldenPath hg19 (UCSC)GDF7  -     chr2:20866424-20871250 +  2p24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GDF7  -     2p24.1   [Description]    (hg38-Dec_2013)
EnsemblGDF7 - 2p24.1 [CytoView hg19]  GDF7 - 2p24.1 [CytoView hg38]
Mapping of homologs : NCBIGDF7 [Mapview hg19]  GDF7 [Mapview hg38]
OMIM604651   
Gene and transcription
Genbank (Entrez)AB158468 AF522369 BC160118
RefSeq transcript (Entrez)NM_182828
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929299
Consensus coding sequences : CCDS (NCBI)GDF7
Cluster EST : UnigeneHs.447688 [ NCBI ]
CGAP (NCI)Hs.447688
Alternative Splicing GalleryENSG00000143869
Gene ExpressionGDF7 [ NCBI-GEO ]   GDF7 [ EBI - ARRAY_EXPRESS ]   GDF7 [ SEEK ]   GDF7 [ MEM ]
Gene Expression Viewer (FireBrowse)GDF7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)151449
GTEX Portal (Tissue expression)GDF7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z4P5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z4P5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z4P5
Splice isoforms : SwissVarQ7Z4P5
PhosPhoSitePlusQ7Z4P5
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    TGF-b_C    TGF-b_N    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)GDF7
DMDM Disease mutations151449
Blocks (Seattle)GDF7
SuperfamilyQ7Z4P5
Human Protein AtlasENSG00000143869
Peptide AtlasQ7Z4P5
HPRD06873
IPIIPI00337348   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z4P5
IntAct (EBI)Q7Z4P5
FunCoupENSG00000143869
BioGRIDGDF7
STRING (EMBL)GDF7
ZODIACGDF7
Ontologies - Pathways
QuickGOQ7Z4P5
Ontology : AmiGOcytokine activity  transforming growth factor beta receptor binding  protein binding  extracellular space  axon guidance  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  roof plate formation  spinal cord association neuron differentiation  gland morphogenesis  BMP signaling pathway  epithelial cell differentiation  midbrain development  activin receptor signaling pathway  growth  protein homodimerization activity  regulation of apoptotic process  regulation of MAPK cascade  cell fate commitment  positive regulation of neuron differentiation  positive regulation of transcription, DNA-templated  cell development  reproductive structure development  branching morphogenesis of an epithelial tube  forebrain morphogenesis  pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  morphogenesis of an epithelial fold  positive regulation of tendon cell differentiation  
Ontology : EGO-EBIcytokine activity  transforming growth factor beta receptor binding  protein binding  extracellular space  axon guidance  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  roof plate formation  spinal cord association neuron differentiation  gland morphogenesis  BMP signaling pathway  epithelial cell differentiation  midbrain development  activin receptor signaling pathway  growth  protein homodimerization activity  regulation of apoptotic process  regulation of MAPK cascade  cell fate commitment  positive regulation of neuron differentiation  positive regulation of transcription, DNA-templated  cell development  reproductive structure development  branching morphogenesis of an epithelial tube  forebrain morphogenesis  pathway-restricted SMAD protein phosphorylation  SMAD protein signal transduction  morphogenesis of an epithelial fold  positive regulation of tendon cell differentiation  
Pathways : KEGGTGF-beta signaling pathway    Hippo signaling pathway   
NDEx NetworkGDF7
Atlas of Cancer Signalling NetworkGDF7
Wikipedia pathwaysGDF7
Orthology - Evolution
OrthoDB151449
GeneTree (enSembl)ENSG00000143869
Phylogenetic Trees/Animal Genes : TreeFamGDF7
HOVERGENQ7Z4P5
HOGENOMQ7Z4P5
Homologs : HomoloGeneGDF7
Homology/Alignments : Family Browser (UCSC)GDF7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGDF7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GDF7
dbVarGDF7
ClinVarGDF7
1000_GenomesGDF7 
Exome Variant ServerGDF7
ExAC (Exome Aggregation Consortium)GDF7 (select the gene name)
Genetic variants : HAPMAP151449
Genomic Variants (DGV)GDF7 [DGVbeta]
DECIPHER (Syndromes)2:20866424-20871250  ENSG00000143869
CONAN: Copy Number AnalysisGDF7 
Mutations
ICGC Data PortalGDF7 
TCGA Data PortalGDF7 
Broad Tumor PortalGDF7
OASIS PortalGDF7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGDF7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGDF7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GDF7
DgiDB (Drug Gene Interaction Database)GDF7
DoCM (Curated mutations)GDF7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GDF7 (select a term)
intoGenGDF7
Cancer3DGDF7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604651   
Orphanet
MedgenGDF7
Genetic Testing Registry GDF7
NextProtQ7Z4P5 [Medical]
TSGene151449
GENETestsGDF7
Huge Navigator GDF7 [HugePedia]
snp3D : Map Gene to Disease151449
BioCentury BCIQGDF7
ClinGenGDF7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD151449
Chemical/Pharm GKB GenePA28637
Clinical trialGDF7
Miscellaneous
canSAR (ICR)GDF7 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGDF7
EVEXGDF7
GoPubMedGDF7
iHOPGDF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:02:15 CEST 2017

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