GINS3 (GINS complex subunit 3)

2010-04-01  

Identity

HGNC
GINS3
LOCATION
16q21
LOCUSID
64785
ALIAS
PSF3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64785
MIM: 610610
HGNC: 25851
Ensembl: ENSG00000181938

Variants:

dbSNP: 64785
ClinVar: 64785
TCGA: ENSG00000181938
COSMIC: GINS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181938ENST00000318129Q9BRX5
ENSG00000181938ENST00000318129A0A0S2Z5L0
ENSG00000181938ENST00000328514Q9BRX5
ENSG00000181938ENST00000328514A0A0S2Z5L4
ENSG00000181938ENST00000426538Q9BRX5
ENSG00000181938ENST00000426538A0A0S2Z5P2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
GINS complexKEGGhsa_M00286
GINS complexKEGGM00286
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
193054082009Common variants at ten loci influence QT interval duration in the QTGEN Study.190
127301342003GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.140
196520972009Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization.49
169907922006Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins.38
231273372013Psf3 is a prognostic biomarker in lung adenocarcinoma.10
262919872015Significant role of Psf3 expression in non-small-cell lung cancer.10
200599672010PSF3 marks malignant colon cancer and has a role in cancer cell proliferation.9
255202512015Adipose tissue gene expression and metabolic health of obese adults.9
171272132006A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS.7
270059772016Psf3 is a prognostic biomarker in lung adenocarcinoma: a larger trial using tissue microarrays of 864 consecutive resections.4

Citation

Dessen P

GINS3 (GINS complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51419/gins3