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GLO1 (glyoxalase I)

Identity

Alias_symbol (synonym)GLOD1
Other aliasGLYI
HEL-S-74
HGNC (Hugo) GLO1
LocusID (NCBI) 2739
Atlas_Id 43930
Location 6p21.2  [Link to chromosome band 6p21]
Location_base_pair Starts at 38675926 and ends at 38703176 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GLO1 (6p21.2) / GLO1 (6p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLO1   4323
Cards
Entrez_Gene (NCBI)GLO1  2739  glyoxalase I
AliasesGLOD1; GLYI; HEL-S-74
GeneCards (Weizmann)GLO1
Ensembl hg19 (Hinxton)ENSG00000124767 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124767 [Gene_View]  ENSG00000124767 [Sequence]  chr6:38675926-38703176 [Contig_View]  GLO1 [Vega]
ICGC DataPortalENSG00000124767
TCGA cBioPortalGLO1
AceView (NCBI)GLO1
Genatlas (Paris)GLO1
WikiGenes2739
SOURCE (Princeton)GLO1
Genetics Home Reference (NIH)GLO1
Genomic and cartography
GoldenPath hg38 (UCSC)GLO1  -     chr6:38675926-38703176 -  6p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLO1  -     6p21.2   [Description]    (hg19-Feb_2009)
EnsemblGLO1 - 6p21.2 [CytoView hg19]  GLO1 - 6p21.2 [CytoView hg38]
Mapping of homologs : NCBIGLO1 [Mapview hg19]  GLO1 [Mapview hg38]
OMIM138750   
Gene and transcription
Genbank (Entrez)AB209801 AK129573 AK130312 AK293345 AK312662
RefSeq transcript (Entrez)NM_006708
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLO1
Cluster EST : UnigeneHs.268849 [ NCBI ]
CGAP (NCI)Hs.268849
Alternative Splicing GalleryENSG00000124767
Gene ExpressionGLO1 [ NCBI-GEO ]   GLO1 [ EBI - ARRAY_EXPRESS ]   GLO1 [ SEEK ]   GLO1 [ MEM ]
Gene Expression Viewer (FireBrowse)GLO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2739
GTEX Portal (Tissue expression)GLO1
Human Protein AtlasENSG00000124767-GLO1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04760   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04760  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04760
Splice isoforms : SwissVarQ04760
Catalytic activity : Enzyme4.4.1.5 [ Enzyme-Expasy ]   4.4.1.54.4.1.5 [ IntEnz-EBI ]   4.4.1.5 [ BRENDA ]   4.4.1.5 [ KEGG ]   
PhosPhoSitePlusQ04760
Domaine pattern : Prosite (Expaxy)GLYOXALASE_I_1 (PS00934)    GLYOXALASE_I_2 (PS00935)    VOC (PS51819)   
Domains : Interpro (EBI)Glyas_Bleomycin-R_OHBP_Dase    Glyas_Fos-R_dOase_dom    Glyoxalase_1    Glyoxalase_1_CS    VOC   
Domain families : Pfam (Sanger)Glyoxalase (PF00903)   
Domain families : Pfam (NCBI)pfam00903   
Conserved Domain (NCBI)GLO1
DMDM Disease mutations2739
Blocks (Seattle)GLO1
PDB (SRS)1BH5    1FRO    1QIN    1QIP    3VW9    3W0T    3W0U   
PDB (PDBSum)1BH5    1FRO    1QIN    1QIP    3VW9    3W0T    3W0U   
PDB (IMB)1BH5    1FRO    1QIN    1QIP    3VW9    3W0T    3W0U   
PDB (RSDB)1BH5    1FRO    1QIN    1QIP    3VW9    3W0T    3W0U   
Structural Biology KnowledgeBase1BH5    1FRO    1QIN    1QIP    3VW9    3W0T    3W0U   
SCOP (Structural Classification of Proteins)1BH5    1FRO    1QIN    1QIP    3VW9    3W0T    3W0U   
CATH (Classification of proteins structures)1BH5    1FRO    1QIN    1QIP    3VW9    3W0T    3W0U   
SuperfamilyQ04760
Human Protein Atlas [tissue]ENSG00000124767-GLO1 [tissue]
Peptide AtlasQ04760
HPRD00730
IPIIPI00220766   IPI01021703   
Protein Interaction databases
DIP (DOE-UCLA)Q04760
IntAct (EBI)Q04760
FunCoupENSG00000124767
BioGRIDGLO1
STRING (EMBL)GLO1
ZODIACGLO1
Ontologies - Pathways
QuickGOQ04760
Ontology : AmiGOlactoylglutathione lyase activity  lactoylglutathione lyase activity  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  carbohydrate metabolic process  pyruvate metabolic process  regulation of transcription by RNA polymerase II  glutathione metabolic process  zinc ion binding  methylglyoxal metabolic process  osteoclast differentiation  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  extracellular exosome  
Ontology : EGO-EBIlactoylglutathione lyase activity  lactoylglutathione lyase activity  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  carbohydrate metabolic process  pyruvate metabolic process  regulation of transcription by RNA polymerase II  glutathione metabolic process  zinc ion binding  methylglyoxal metabolic process  osteoclast differentiation  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  extracellular exosome  
Pathways : KEGGPyruvate metabolism   
NDEx NetworkGLO1
Atlas of Cancer Signalling NetworkGLO1
Wikipedia pathwaysGLO1
Orthology - Evolution
OrthoDB2739
GeneTree (enSembl)ENSG00000124767
Phylogenetic Trees/Animal Genes : TreeFamGLO1
HOVERGENQ04760
HOGENOMQ04760
Homologs : HomoloGeneGLO1
Homology/Alignments : Family Browser (UCSC)GLO1
Gene fusions - Rearrangements
Fusion : QuiverGLO1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLO1
dbVarGLO1
ClinVarGLO1
1000_GenomesGLO1 
Exome Variant ServerGLO1
ExAC (Exome Aggregation Consortium)ENSG00000124767
GNOMAD BrowserENSG00000124767
Varsome BrowserGLO1
Genetic variants : HAPMAP2739
Genomic Variants (DGV)GLO1 [DGVbeta]
DECIPHERGLO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLO1 
Mutations
ICGC Data PortalGLO1 
TCGA Data PortalGLO1 
Broad Tumor PortalGLO1
OASIS PortalGLO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GLO1
DgiDB (Drug Gene Interaction Database)GLO1
DoCM (Curated mutations)GLO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLO1 (select a term)
intoGenGLO1
Cancer3DGLO1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138750   
Orphanet
DisGeNETGLO1
MedgenGLO1
Genetic Testing Registry GLO1
NextProtQ04760 [Medical]
TSGene2739
GENETestsGLO1
Target ValidationGLO1
Huge Navigator GLO1 [HugePedia]
snp3D : Map Gene to Disease2739
BioCentury BCIQGLO1
ClinGenGLO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2739
Chemical/Pharm GKB GenePA28724
Clinical trialGLO1
Miscellaneous
canSAR (ICR)GLO1 (select the gene name)
Probes
Litterature
PubMed134 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLO1
EVEXGLO1
GoPubMedGLO1
iHOPGLO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:08:39 CET 2018

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