GLP1R (glucagon like peptide 1 receptor)

2007-02-01  

Identity

HGNC
LOCATION
6p21.2
LOCUSID
ALIAS
GLP-1,GLP-1-R,GLP-1R

Other Information

Locus ID:

NCBI: 2740
MIM: 138032
HGNC: 4324
Ensembl: ENSG00000112164

Variants:

dbSNP: 2740
ClinVar: 2740
TCGA: ENSG00000112164
COSMIC: GLP1R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112164ENST00000373256P43220

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Insulin secretionKEGGhsa04911
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748978sitagliptinChemicalClinicalAnnotationassociatedPD27160388
PA164749238exenatideChemicalVariantAnnotationassociatedPD30883264
PA165958346vildagliptinChemicalClinicalAnnotationassociatedPD27160388
PA165958364liraglutideChemicalClinicalAnnotationassociatedPD25991051
PA443890Diabetes Mellitus, Type 2DiseaseClinicalAnnotation, VariantAnnotationassociatedPD27160388, 30883264
PA445131ObesityDiseaseClinicalAnnotationassociatedPD25991051
PA445376Polycystic Ovary SyndromeDiseaseClinicalAnnotationassociatedPD25991051
PA447216SchizophreniaDiseaseClinicalAnnotationassociated24624910
PA449061clozapineChemicalClinicalAnnotationassociated24624910
PA450688olanzapineChemicalClinicalAnnotationassociated24624910

References

Pubmed IDYearTitleCitations
244677462014GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody.140
182871022008Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.122
202252482010Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway.114
174759612007GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting.95
198617222010Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.95
217452712011Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis.92
193866262009Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
250710232014GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans.74
185417092008Expression of the GLP-1 receptor in mouse, rat, and human pancreas.72

Citation

Dessen P

GLP1R (glucagon like peptide 1 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46453/glp1r