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GLP1R (glucagon like peptide 1 receptor)

Identity

Alias_namesglucagon-like peptide 1 receptor
Other aliasGLP-1
GLP-1-R
GLP-1R
HGNC (Hugo) GLP1R
LocusID (NCBI) 2740
Atlas_Id 46453
Location 6p21.2  [Link to chromosome band 6p21]
Location_base_pair Starts at 39048781 and ends at 39091303 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLP1R   4324
Cards
Entrez_Gene (NCBI)GLP1R  2740  glucagon like peptide 1 receptor
AliasesGLP-1; GLP-1-R; GLP-1R
GeneCards (Weizmann)GLP1R
Ensembl hg19 (Hinxton)ENSG00000112164 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112164 [Gene_View]  ENSG00000112164 [Sequence]  chr6:39048781-39091303 [Contig_View]  GLP1R [Vega]
ICGC DataPortalENSG00000112164
TCGA cBioPortalGLP1R
AceView (NCBI)GLP1R
Genatlas (Paris)GLP1R
WikiGenes2740
SOURCE (Princeton)GLP1R
Genetics Home Reference (NIH)GLP1R
Genomic and cartography
GoldenPath hg38 (UCSC)GLP1R  -     chr6:39048781-39091303 +  6p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GLP1R  -     6p21.2   [Description]    (hg19-Feb_2009)
EnsemblGLP1R - 6p21.2 [CytoView hg19]  GLP1R - 6p21.2 [CytoView hg38]
Mapping of homologs : NCBIGLP1R [Mapview hg19]  GLP1R [Mapview hg38]
OMIM138032   
Gene and transcription
Genbank (Entrez)BC112126 BC113493 CK819862 KR138540 L23503
RefSeq transcript (Entrez)NM_002062
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GLP1R
Cluster EST : UnigeneHs.389103 [ NCBI ]
CGAP (NCI)Hs.389103
Alternative Splicing GalleryENSG00000112164
Gene ExpressionGLP1R [ NCBI-GEO ]   GLP1R [ EBI - ARRAY_EXPRESS ]   GLP1R [ SEEK ]   GLP1R [ MEM ]
Gene Expression Viewer (FireBrowse)GLP1R [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2740
GTEX Portal (Tissue expression)GLP1R
Human Protein AtlasENSG00000112164-GLP1R [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43220   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43220  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43220
Splice isoforms : SwissVarP43220
PhosPhoSitePlusP43220
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_1 (PS00649)    G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)GPCR_2-like    GPCR_2_extracell_dom_sf    GPCR_2_extracellular_dom    GPCR_2_GLP1/glucagon_rcpt    GPCR_2_GLP1_rcpt    GPCR_2_secretin-like    GPCR_2_secretin-like_CS   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    HRM (PF02793)   
Domain families : Pfam (NCBI)pfam00002    pfam02793   
Domain families : Smart (EMBL)HormR (SM00008)  
Conserved Domain (NCBI)GLP1R
DMDM Disease mutations2740
Blocks (Seattle)GLP1R
PDB (SRS)3C59    3C5T    3IOL    4ZGM    5E94    5NX2    5VEW    5VEX    6B3J   
PDB (PDBSum)3C59    3C5T    3IOL    4ZGM    5E94    5NX2    5VEW    5VEX    6B3J   
PDB (IMB)3C59    3C5T    3IOL    4ZGM    5E94    5NX2    5VEW    5VEX    6B3J   
PDB (RSDB)3C59    3C5T    3IOL    4ZGM    5E94    5NX2    5VEW    5VEX    6B3J   
Structural Biology KnowledgeBase3C59    3C5T    3IOL    4ZGM    5E94    5NX2    5VEW    5VEX    6B3J   
SCOP (Structural Classification of Proteins)3C59    3C5T    3IOL    4ZGM    5E94    5NX2    5VEW    5VEX    6B3J   
CATH (Classification of proteins structures)3C59    3C5T    3IOL    4ZGM    5E94    5NX2    5VEW    5VEX    6B3J   
SuperfamilyP43220
Human Protein Atlas [tissue]ENSG00000112164-GLP1R [tissue]
Peptide AtlasP43220
HPRD00677
IPIIPI00300576   
Protein Interaction databases
DIP (DOE-UCLA)P43220
IntAct (EBI)P43220
FunCoupENSG00000112164
BioGRIDGLP1R
STRING (EMBL)GLP1R
ZODIACGLP1R
Ontologies - Pathways
QuickGOP43220
Ontology : AmiGOtransmembrane signaling receptor activity  glucagon receptor activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  activation of adenylate cyclase activity  positive regulation of cytosolic calcium ion concentration  learning or memory  regulation of heart contraction  G protein-coupled peptide receptor activity  integral component of membrane  peptide hormone binding  cAMP-mediated signaling  glucagon-like peptide 1 receptor activity  positive regulation of blood pressure  regulation of insulin secretion  cellular response to glucagon stimulus  response to psychosocial stress  
Ontology : EGO-EBItransmembrane signaling receptor activity  glucagon receptor activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  adenylate cyclase-activating G protein-coupled receptor signaling pathway  activation of adenylate cyclase activity  positive regulation of cytosolic calcium ion concentration  learning or memory  regulation of heart contraction  G protein-coupled peptide receptor activity  integral component of membrane  peptide hormone binding  cAMP-mediated signaling  glucagon-like peptide 1 receptor activity  positive regulation of blood pressure  regulation of insulin secretion  cellular response to glucagon stimulus  response to psychosocial stress  
Pathways : KEGGNeuroactive ligand-receptor interaction    Insulin secretion   
NDEx NetworkGLP1R
Atlas of Cancer Signalling NetworkGLP1R
Wikipedia pathwaysGLP1R
Orthology - Evolution
OrthoDB2740
GeneTree (enSembl)ENSG00000112164
Phylogenetic Trees/Animal Genes : TreeFamGLP1R
HOVERGENP43220
HOGENOMP43220
Homologs : HomoloGeneGLP1R
Homology/Alignments : Family Browser (UCSC)GLP1R
Gene fusions - Rearrangements
Fusion : QuiverGLP1R
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLP1R [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLP1R
dbVarGLP1R
ClinVarGLP1R
1000_GenomesGLP1R 
Exome Variant ServerGLP1R
ExAC (Exome Aggregation Consortium)ENSG00000112164
GNOMAD BrowserENSG00000112164
Varsome BrowserGLP1R
Genetic variants : HAPMAP2740
Genomic Variants (DGV)GLP1R [DGVbeta]
DECIPHERGLP1R [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGLP1R 
Mutations
ICGC Data PortalGLP1R 
TCGA Data PortalGLP1R 
Broad Tumor PortalGLP1R
OASIS PortalGLP1R [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLP1R  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLP1R
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GLP1R
DgiDB (Drug Gene Interaction Database)GLP1R
DoCM (Curated mutations)GLP1R (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLP1R (select a term)
intoGenGLP1R
Cancer3DGLP1R(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138032   
Orphanet
DisGeNETGLP1R
MedgenGLP1R
Genetic Testing Registry GLP1R
NextProtP43220 [Medical]
TSGene2740
GENETestsGLP1R
Target ValidationGLP1R
Huge Navigator GLP1R [HugePedia]
snp3D : Map Gene to Disease2740
BioCentury BCIQGLP1R
ClinGenGLP1R
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2740
Chemical/Pharm GKB GenePA28725
Clinical trialGLP1R
Miscellaneous
canSAR (ICR)GLP1R (select the gene name)
Probes
Litterature
PubMed189 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLP1R
EVEXGLP1R
GoPubMedGLP1R
iHOPGLP1R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:08:40 CET 2018

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