GLUL (glutamate-ammonia ligase)

2007-02-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
GLNS,GS,PIG43,PIG59
FUSION GENES

Other Information

Locus ID:

NCBI: 2752
MIM: 138290
HGNC: 4341
Ensembl: ENSG00000135821

Variants:

dbSNP: 2752
ClinVar: 2752
TCGA: ENSG00000135821
COSMIC: GLUL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135821ENST00000311223P15104
ENSG00000135821ENST00000311223A8YXX4
ENSG00000135821ENST00000331872P15104
ENSG00000135821ENST00000331872A8YXX4
ENSG00000135821ENST00000339526P15104
ENSG00000135821ENST00000339526A8YXX4
ENSG00000135821ENST00000417584P15104
ENSG00000135821ENST00000417584A8YXX4
ENSG00000135821ENST00000642379A0A2R8YDT1

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Glyoxylate and dicarboxylate metabolismKEGGko00630
Nitrogen metabolismKEGGko00910
Arginine biosynthesisKEGGhsa00220
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
Nitrogen metabolismKEGGhsa00910
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Metabolic pathwaysKEGGhsa01100
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter uptake and Metabolism In Glial CellsREACTOMER-HSA-112313
Astrocytic Glutamate-Glutamine Uptake And MetabolismREACTOMER-HSA-210455
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121609382002Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.135
265953832015Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.124
278291382016Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.76
192310032009The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma.52
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
204710302010Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.42
269909862016Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.37
180059872008Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.36
288136762017Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.36
202338822010Glutamine synthetase immunostaining correlates with pathologic features of hepatocellular carcinoma and better survival after radiofrequency thermal ablation.21

Citation

Dessen P

GLUL (glutamate-ammonia ligase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45958/glul