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GLUL (glutamate-ammonia ligase)

Identity

Alias_namesGLNS
glutamate-ammonia ligase (glutamine synthase)
Other aliasGS
PIG43
PIG59
HGNC (Hugo) GLUL
LocusID (NCBI) 2752
Atlas_Id 45958
Location 1q25.3  [Link to chromosome band 1q25]
Location_base_pair Starts at 182347228 and ends at 182361341 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ART3 (4q21.1) / GLUL (1q25.3)GLUL (1q25.3) / DDX27 (20q13.13)GLUL (1q25.3) / GLUL (1q25.3)
GLUL (1q25.3) / SEC63 (6q21)GLUL (1q25.3) / SLC24A2 (9p22.1)GLUL (1q25.3) / UNC13A (19p13.11)
GRAMD3 (5q23.2) / GLUL (1q25.3)MTIF2 (2p16.1) / GLUL (1q25.3)PROS1 (3q11.1) / GLUL (1q25.3)
RUFY1 (5q35.3) / GLUL (1q25.3)SERP1 (3q25.1) / GLUL (1q25.3)WDR74 (11q12.3) / GLUL (1q25.3)
GLUL 1q25.3 / DDX27 20q13.13GLUL 1q25.3 / SEC63 6q21GLUL 1q25.3 / UNC13A 19p13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GLUL   4341
Cards
Entrez_Gene (NCBI)GLUL  2752  glutamate-ammonia ligase
AliasesGLNS; GS; PIG43; PIG59
GeneCards (Weizmann)GLUL
Ensembl hg19 (Hinxton)ENSG00000135821 [Gene_View]  chr1:182347228-182361341 [Contig_View]  GLUL [Vega]
Ensembl hg38 (Hinxton)ENSG00000135821 [Gene_View]  chr1:182347228-182361341 [Contig_View]  GLUL [Vega]
ICGC DataPortalENSG00000135821
TCGA cBioPortalGLUL
AceView (NCBI)GLUL
Genatlas (Paris)GLUL
WikiGenes2752
SOURCE (Princeton)GLUL
Genetics Home Reference (NIH)GLUL
Genomic and cartography
GoldenPath hg19 (UCSC)GLUL  -     chr1:182347228-182361341 -  1q25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GLUL  -     1q25.3   [Description]    (hg38-Dec_2013)
EnsemblGLUL - 1q25.3 [CytoView hg19]  GLUL - 1q25.3 [CytoView hg38]
Mapping of homologs : NCBIGLUL [Mapview hg19]  GLUL [Mapview hg38]
OMIM138290   610015   
Gene and transcription
Genbank (Entrez)AI147221 AI286093 AK092874 AK122784 AK301600
RefSeq transcript (Entrez)NM_001033044 NM_001033056 NM_002065
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_013347 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)GLUL
Cluster EST : UnigeneHs.518525 [ NCBI ]
CGAP (NCI)Hs.518525
Alternative Splicing GalleryENSG00000135821
Gene ExpressionGLUL [ NCBI-GEO ]   GLUL [ EBI - ARRAY_EXPRESS ]   GLUL [ SEEK ]   GLUL [ MEM ]
Gene Expression Viewer (FireBrowse)GLUL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2752
GTEX Portal (Tissue expression)GLUL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15104   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15104  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15104
Splice isoforms : SwissVarP15104
Catalytic activity : Enzyme6.3.1.2 [ Enzyme-Expasy ]   6.3.1.26.3.1.2 [ IntEnz-EBI ]   6.3.1.2 [ BRENDA ]   6.3.1.2 [ KEGG ]   
PhosPhoSitePlusP15104
Domaine pattern : Prosite (Expaxy)GLNA_1 (PS00180)    GLNA_ATP (PS00181)   
Domains : Interpro (EBI)Gln_synt_b-grasp    Gln_synth/guanido_kin_cat_dom    Gln_synth_cat_dom    Gln_synth_gly_rich_site    Gln_synth_N_conserv_site   
Domain families : Pfam (Sanger)Gln-synt_C (PF00120)    Gln-synt_N (PF03951)   
Domain families : Pfam (NCBI)pfam00120    pfam03951   
Conserved Domain (NCBI)GLUL
DMDM Disease mutations2752
Blocks (Seattle)GLUL
PDB (SRS)2OJW    2QC8   
PDB (PDBSum)2OJW    2QC8   
PDB (IMB)2OJW    2QC8   
PDB (RSDB)2OJW    2QC8   
Structural Biology KnowledgeBase2OJW    2QC8   
SCOP (Structural Classification of Proteins)2OJW    2QC8   
CATH (Classification of proteins structures)2OJW    2QC8   
SuperfamilyP15104
Human Protein AtlasENSG00000135821
Peptide AtlasP15104
HPRD00701
IPIIPI00010130   IPI00942956   
Protein Interaction databases
DIP (DOE-UCLA)P15104
IntAct (EBI)P15104
FunCoupENSG00000135821
BioGRIDGLUL
STRING (EMBL)GLUL
ZODIACGLUL
Ontologies - Pathways
QuickGOP15104
Ontology : AmiGOmagnesium ion binding  neurotransmitter uptake  glutamate decarboxylase activity  glutamate-ammonia ligase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  rough endoplasmic reticulum  cytosol  glutamate catabolic process  glutamine biosynthetic process  cell proliferation  cellular amino acid biosynthetic process  cellular response to starvation  response to glucose  glutamate binding  ammonia assimilation cycle  manganese ion binding  positive regulation of insulin secretion  identical protein binding  perikaryon  myelin sheath  protein complex  axon terminus  dynein light chain binding  positive regulation of epithelial cell proliferation  protein homooligomerization  positive regulation of synaptic transmission, glutamatergic  extracellular exosome  glial cell projection  
Ontology : EGO-EBImagnesium ion binding  neurotransmitter uptake  glutamate decarboxylase activity  glutamate-ammonia ligase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  rough endoplasmic reticulum  cytosol  glutamate catabolic process  glutamine biosynthetic process  cell proliferation  cellular amino acid biosynthetic process  cellular response to starvation  response to glucose  glutamate binding  ammonia assimilation cycle  manganese ion binding  positive regulation of insulin secretion  identical protein binding  perikaryon  myelin sheath  protein complex  axon terminus  dynein light chain binding  positive regulation of epithelial cell proliferation  protein homooligomerization  positive regulation of synaptic transmission, glutamatergic  extracellular exosome  glial cell projection  
Pathways : KEGGAlanine, aspartate and glutamate metabolism    Arginine and proline metabolism    Glyoxylate and dicarboxylate metabolism    Nitrogen metabolism    Glutamatergic synapse    GABAergic synapse   
NDEx NetworkGLUL
Atlas of Cancer Signalling NetworkGLUL
Wikipedia pathwaysGLUL
Orthology - Evolution
OrthoDB2752
GeneTree (enSembl)ENSG00000135821
Phylogenetic Trees/Animal Genes : TreeFamGLUL
HOVERGENP15104
HOGENOMP15104
Homologs : HomoloGeneGLUL
Homology/Alignments : Family Browser (UCSC)GLUL
Gene fusions - Rearrangements
Fusion : MitelmanGLUL/DDX27 [1q25.3/20q13.13]  
Fusion : MitelmanGLUL/SEC63 [1q25.3/6q21]  [t(1;6)(q25;q21)]  
Fusion : MitelmanGLUL/UNC13A [1q25.3/19p13.11]  [t(1;19)(q25;p13)]  
Fusion: TCGAGLUL 1q25.3 DDX27 20q13.13 BRCA
Fusion: TCGAGLUL 1q25.3 SEC63 6q21 LGG
Fusion: TCGAGLUL 1q25.3 UNC13A 19p13.11 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGLUL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GLUL
dbVarGLUL
ClinVarGLUL
1000_GenomesGLUL 
Exome Variant ServerGLUL
ExAC (Exome Aggregation Consortium)GLUL (select the gene name)
Genetic variants : HAPMAP2752
Genomic Variants (DGV)GLUL [DGVbeta]
DECIPHER (Syndromes)1:182347228-182361341  ENSG00000135821
CONAN: Copy Number AnalysisGLUL 
Mutations
ICGC Data PortalGLUL 
TCGA Data PortalGLUL 
Broad Tumor PortalGLUL
OASIS PortalGLUL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGLUL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGLUL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GLUL
DgiDB (Drug Gene Interaction Database)GLUL
DoCM (Curated mutations)GLUL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GLUL (select a term)
intoGenGLUL
Cancer3DGLUL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138290    610015   
Orphanet11000   
MedgenGLUL
Genetic Testing Registry GLUL
NextProtP15104 [Medical]
TSGene2752
GENETestsGLUL
Huge Navigator GLUL [HugePedia]
snp3D : Map Gene to Disease2752
BioCentury BCIQGLUL
ClinGenGLUL (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2752
Chemical/Pharm GKB GenePA28743
Clinical trialGLUL
Miscellaneous
canSAR (ICR)GLUL (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGLUL
EVEXGLUL
GoPubMedGLUL
iHOPGLUL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:02:33 CEST 2017

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