Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2)

Identity

Other namesGIP
GNAI2B
H_LUCA15.1
H_LUCA16.1
HGNC (Hugo) GNAI2
LocusID (NCBI) 2771
Atlas_Id 40726
Location 3p21.31
Location_base_pair Starts at 50284326 and ends at 50296786 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GNAI2   4385
Cards
Entrez_Gene (NCBI)GNAI2  2771  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GeneCards (Weizmann)GNAI2
Ensembl hg19 (Hinxton)ENSG00000114353 [Gene_View]  chr3:50284326-50296786 [Contig_View]  GNAI2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114353 [Gene_View]  chr3:50284326-50296786 [Contig_View]  GNAI2 [Vega]
ICGC DataPortalENSG00000114353
TCGA cBioPortalGNAI2
AceView (NCBI)GNAI2
Genatlas (Paris)GNAI2
WikiGenes2771
SOURCE (Princeton)GNAI2
Genomic and cartography
GoldenPath hg19 (UCSC)GNAI2  -     chr3:50284326-50296786 +  3p21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GNAI2  -     3p21.31   [Description]    (hg38-Dec_2013)
EnsemblGNAI2 - 3p21.31 [CytoView hg19]  GNAI2 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIGNAI2 [Mapview hg19]  GNAI2 [Mapview hg38]
OMIM139360   192605   
Gene and transcription
Genbank (Entrez)AF493906 AK055574 AK096299 AK096595 AK126708
RefSeq transcript (Entrez)NM_001166425 NM_001282617 NM_001282618 NM_001282619 NM_001282620 NM_002070
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_016002 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)GNAI2
Cluster EST : UnigeneHs.77269 [ NCBI ]
CGAP (NCI)Hs.77269
Alternative Splicing : Fast-db (Paris)GSHG0020817
Alternative Splicing GalleryENSG00000114353
Gene ExpressionGNAI2 [ NCBI-GEO ]     GNAI2 [ SEEK ]   GNAI2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04899 (Uniprot)
NextProtP04899  [Medical]  [Publications]
With graphics : InterProP04899
Splice isoforms : SwissVarP04899 (Swissvar)
Domains : Interpro (EBI)Gprotein_alpha_I    Gprotein_alpha_su    GproteinA_insert    P-loop_NTPase   
Related proteins : CluSTrP04899
Domain families : Pfam (Sanger)G-alpha (PF00503)   
Domain families : Pfam (NCBI)pfam00503   
Domain families : Smart (EMBL)G_alpha (SM00275)  
DMDM Disease mutations2771
Blocks (Seattle)P04899
Human Protein AtlasENSG00000114353
Peptide AtlasP04899
HPRD00764
IPIIPI00748145   IPI00217906   IPI00926935   IPI01015661   IPI00925504   IPI00924892   IPI00924659   IPI00924427   
Protein Interaction databases
DIP (DOE-UCLA)P04899
IntAct (EBI)P04899
FunCoupENSG00000114353
BioGRIDGNAI2
IntegromeDBGNAI2
STRING (EMBL)GNAI2
Ontologies - Pathways
QuickGOP04899
Ontology : AmiGOactivation of MAPKK activity  G-protein coupled receptor binding  adenosine receptor signaling pathway  GTPase activity  signal transducer activity  protein binding  GTP binding  nucleoplasm  cytoplasm  centrosome  cytosol  heterotrimeric G-protein complex  plasma membrane  plasma membrane  cell cycle  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  G-protein coupled acetylcholine receptor signaling pathway  gamma-aminobutyric acid signaling pathway  synaptic transmission  response to nutrient  blood coagulation  metabolic process  metabolic process  cell proliferation  positive regulation of cell proliferation  membrane  platelet activation  midbody  G-protein beta/gamma-subunit complex binding  intracellular signal transduction  membrane raft  metal ion binding  negative regulation of synaptic transmission  cell division  regulation of calcium ion transport  extracellular exosome  extracellular vesicle  
Ontology : EGO-EBIactivation of MAPKK activity  G-protein coupled receptor binding  adenosine receptor signaling pathway  GTPase activity  signal transducer activity  protein binding  GTP binding  nucleoplasm  cytoplasm  centrosome  cytosol  heterotrimeric G-protein complex  plasma membrane  plasma membrane  cell cycle  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  G-protein coupled acetylcholine receptor signaling pathway  gamma-aminobutyric acid signaling pathway  synaptic transmission  response to nutrient  blood coagulation  metabolic process  metabolic process  cell proliferation  positive regulation of cell proliferation  membrane  platelet activation  midbody  G-protein beta/gamma-subunit complex binding  intracellular signal transduction  membrane raft  metal ion binding  negative regulation of synaptic transmission  cell division  regulation of calcium ion transport  extracellular exosome  extracellular vesicle  
Pathways : KEGGRap1 signaling pathway    Chemokine signaling pathway    Adrenergic signaling in cardiomyocytes    Axon guidance    Tight junction    Gap junction    Leukocyte transendothelial migration    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Long-term depression    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Gastric acid secretion    Parkinson's disease    Cocaine addiction    Morphine addiction    Alcoholism    Pertussis    Chagas disease (American trypanosomiasis)    Toxoplasmosis   
Protein Interaction DatabaseGNAI2
DoCM (Curated mutations)GNAI2
Wikipedia pathwaysGNAI2
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerGNAI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNAI2
dbVarGNAI2
ClinVarGNAI2
1000_GenomesGNAI2 
Exome Variant ServerGNAI2
SNP (GeneSNP Utah)GNAI2
SNP : HGBaseGNAI2
Genetic variants : HAPMAPGNAI2
Genomic Variants (DGV)GNAI2 [DGVbeta]
Mutations
ICGC Data PortalGNAI2 
TCGA Data PortalGNAI2 
Tumor PortalGNAI2
Somatic Mutations in Cancer : COSMICGNAI2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:50284326-50296786
CONAN: Copy Number AnalysisGNAI2 
Mutations and Diseases : HGMDGNAI2
OMIM139360    192605   
MedgenGNAI2
NextProtP04899 [Medical]
GENETestsGNAI2
Disease Genetic AssociationGNAI2
Huge Navigator GNAI2 [HugePedia]  GNAI2 [HugeCancerGEM]
snp3D : Map Gene to Disease2771
DGIdb (Drug Gene Interaction db)GNAI2
BioCentury BCIQGNAI2
General knowledge
Homologs : HomoloGeneGNAI2
Homology/Alignments : Family Browser (UCSC)GNAI2
Phylogenetic Trees/Animal Genes : TreeFamGNAI2
Chemical/Protein Interactions : CTD2771
Chemical/Pharm GKB GenePA24347
Clinical trialGNAI2
Cancer Resource (Charite)ENSG00000114353
Other databases
Probes
Litterature
PubMed151 Pubmed reference(s) in Entrez
CoreMineGNAI2
GoPubMedGNAI2
iHOPGNAI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 11:37:17 CEST 2015

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