Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GNAI2 (G protein subunit alpha i2)

Identity

Other namesGIP
GNAI2B
H_LUCA15.1
H_LUCA16.1
HGNC (Hugo) GNAI2
LocusID (NCBI) 2771
Atlas_Id 40726
Location 3p21.31
Location_base_pair Starts at 50284326 and ends at 50296786 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GNAI2 (3p21.31) / GNAI2 (3p21.31)GNAI2 (3p21.31) / H19 (11p15.5)GNAI2 (3p21.31) / MBD5 (2q23.1)
GNAI2 (3p21.31) / NT5DC2 (3p21.1)GNAI2 (3p21.31) / PRKAG1 (12q13.12)GNAI2 (3p21.31) / PSAP (10q22.1)
HSP90AA1 (14q32.31) / GNAI2 (3p21.31)LOC100128993 (8p21.3) / GNAI2 (3p21.31)MBD5 (2q23.1) / GNAI2 (3p21.31)
NPIPB7 (16q23.1) / GNAI2 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GNAI2   4385
Cards
Entrez_Gene (NCBI)GNAI2  2771  G protein subunit alpha i2
GeneCards (Weizmann)GNAI2
Ensembl hg19 (Hinxton)ENSG00000114353 [Gene_View]  chr3:50284326-50296786 [Contig_View]  GNAI2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114353 [Gene_View]  chr3:50284326-50296786 [Contig_View]  GNAI2 [Vega]
ICGC DataPortalENSG00000114353
TCGA cBioPortalGNAI2
AceView (NCBI)GNAI2
Genatlas (Paris)GNAI2
WikiGenes2771
SOURCE (Princeton)GNAI2
Genomic and cartography
GoldenPath hg19 (UCSC)GNAI2  -     chr3:50284326-50296786 +  3p21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GNAI2  -     3p21.31   [Description]    (hg38-Dec_2013)
EnsemblGNAI2 - 3p21.31 [CytoView hg19]  GNAI2 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIGNAI2 [Mapview hg19]  GNAI2 [Mapview hg38]
OMIM139360   192605   
Gene and transcription
Genbank (Entrez)AF493906 AK055574 AK096299 AK096595 AK126708
RefSeq transcript (Entrez)NM_001166425 NM_001282617 NM_001282618 NM_001282619 NM_001282620 NM_002070
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_016002 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)GNAI2
Cluster EST : UnigeneHs.77269 [ NCBI ]
CGAP (NCI)Hs.77269
Alternative Splicing : Fast-db (Paris)GSHG0020817
Alternative Splicing GalleryENSG00000114353
Gene ExpressionGNAI2 [ NCBI-GEO ]   GNAI2 [ EBI - ARRAY_EXPRESS ]   GNAI2 [ SEEK ]   GNAI2 [ MEM ]
Gene Expression Viewer (FireBrowse)GNAI2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)2771
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04899 (Uniprot)
NextProtP04899  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04899
Splice isoforms : SwissVarP04899 (Swissvar)
PhosPhoSitePlusP04899
Domains : Interpro (EBI)Gprotein_alpha_I    Gprotein_alpha_su    GproteinA_insert    P-loop_NTPase   
Domain families : Pfam (Sanger)G-alpha (PF00503)   
Domain families : Pfam (NCBI)pfam00503   
Domain families : Smart (EMBL)G_alpha (SM00275)  
DMDM Disease mutations2771
Blocks (Seattle)GNAI2
SuperfamilyP04899
Human Protein AtlasENSG00000114353
Peptide AtlasP04899
HPRD00764
IPIIPI00748145   IPI00217906   IPI00926935   IPI01015661   IPI00925504   IPI00924892   IPI00924659   IPI00924427   
Protein Interaction databases
DIP (DOE-UCLA)P04899
IntAct (EBI)P04899
FunCoupENSG00000114353
BioGRIDGNAI2
STRING (EMBL)GNAI2
ZODIACGNAI2
Ontologies - Pathways
QuickGOP04899
Ontology : AmiGOactivation of MAPKK activity  G-protein coupled receptor binding  adenosine receptor signaling pathway  GTPase activity  signal transducer activity  protein binding  GTP binding  nucleoplasm  cytoplasm  centrosome  cytosol  heterotrimeric G-protein complex  plasma membrane  plasma membrane  protein folding  cell cycle  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  G-protein coupled acetylcholine receptor signaling pathway  gamma-aminobutyric acid signaling pathway  response to nutrient  metabolic process  cell proliferation  positive regulation of cell proliferation  membrane  dendrite  midbody  G-protein beta/gamma-subunit complex binding  intracellular signal transduction  cell body  membrane raft  metal ion binding  negative regulation of synaptic transmission  cell division  regulation of calcium ion transport  extracellular exosome  extracellular vesicle  
Ontology : EGO-EBIactivation of MAPKK activity  G-protein coupled receptor binding  adenosine receptor signaling pathway  GTPase activity  signal transducer activity  protein binding  GTP binding  nucleoplasm  cytoplasm  centrosome  cytosol  heterotrimeric G-protein complex  plasma membrane  plasma membrane  protein folding  cell cycle  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  G-protein coupled acetylcholine receptor signaling pathway  gamma-aminobutyric acid signaling pathway  response to nutrient  metabolic process  cell proliferation  positive regulation of cell proliferation  membrane  dendrite  midbody  G-protein beta/gamma-subunit complex binding  intracellular signal transduction  cell body  membrane raft  metal ion binding  negative regulation of synaptic transmission  cell division  regulation of calcium ion transport  extracellular exosome  extracellular vesicle  
Pathways : KEGGRap1 signaling pathway    Chemokine signaling pathway    Adrenergic signaling in cardiomyocytes    Axon guidance    Tight junction    Gap junction    Leukocyte transendothelial migration    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Long-term depression    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Gastric acid secretion    Parkinson's disease    Cocaine addiction    Morphine addiction    Alcoholism    Pertussis    Chagas disease (American trypanosomiasis)    Toxoplasmosis   
NDEx Network
Atlas of Cancer Signalling NetworkGNAI2
Wikipedia pathwaysGNAI2
Orthology - Evolution
OrthoDB2771
GeneTree (enSembl)ENSG00000114353
Phylogenetic Trees/Animal Genes : TreeFamGNAI2
Homologs : HomoloGeneGNAI2
Homology/Alignments : Family Browser (UCSC)GNAI2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerGNAI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNAI2
dbVarGNAI2
ClinVarGNAI2
1000_GenomesGNAI2 
Exome Variant ServerGNAI2
ExAC (Exome Aggregation Consortium)GNAI2 (select the gene name)
SNP (GeneSNP Utah)GNAI2
SNP : HGBaseGNAI2
Genetic variants : HAPMAPGNAI2
Genomic Variants (DGV)GNAI2 [DGVbeta]
Mutations
ICGC Data PortalGNAI2 
TCGA Data PortalGNAI2 
Broad Tumor PortalGNAI2
OASIS PortalGNAI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNAI2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNAI2
DgiDB (Drug Gene Interaction Database)GNAI2
DoCM (Curated mutations)GNAI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNAI2 (select a term)
intoGenGNAI2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:50284326-50296786
CONAN: Copy Number AnalysisGNAI2 
Mutations and Diseases : HGMDGNAI2
OMIM139360    192605   
MedgenGNAI2
Genetic Testing Registry GNAI2
NextProtP04899 [Medical]
TSGene2771
GENETestsGNAI2
Huge Navigator GNAI2 [HugePedia]  GNAI2 [HugeCancerGEM]
snp3D : Map Gene to Disease2771
BioCentury BCIQGNAI2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2771
Chemical/Pharm GKB GenePA24347
Clinical trialGNAI2
Miscellaneous
canSAR (ICR)GNAI2 (select the gene name)
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNAI2
GoPubMedGNAI2
iHOPGNAI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:46:19 CEST 2016

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