Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GNAI2 (guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2)

Identity

Other namesGIP
GNAI2B
H_LUCA15.1
H_LUCA16.1
HGNC (Hugo) GNAI2
LocusID (NCBI) 2771
Location 3p21.31
Location_base_pair Starts at 50284326 and ends at 50296786 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GNAI2   4385
Cards
Entrez_Gene (NCBI)GNAI2  2771  guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GeneCards (Weizmann)GNAI2
Ensembl (Hinxton)ENSG00000114353 [Gene_View]  chr3:50284326-50296786 [Contig_View]  GNAI2 [Vega]
ICGC DataPortalENSG00000114353
cBioPortalGNAI2
AceView (NCBI)GNAI2
Genatlas (Paris)GNAI2
WikiGenes2771
SOURCE (Princeton)NM_001166425 NM_001282617 NM_001282618 NM_001282619 NM_001282620 NM_002070
Genomic and cartography
GoldenPath (UCSC)GNAI2  -  3p21.31   chr3:50284326-50296786 +  3p21.31   [Description]    (hg19-Feb_2009)
EnsemblGNAI2 - 3p21.31 [CytoView]
Mapping of homologs : NCBIGNAI2 [Mapview]
OMIM139360   192605   
Gene and transcription
Genbank (Entrez)AF493906 AK055574 AK096299 AK096595 AK126708
RefSeq transcript (Entrez)NM_001166425 NM_001282617 NM_001282618 NM_001282619 NM_001282620 NM_002070
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_016002 NT_022517 NW_001838877 NW_004929309
Consensus coding sequences : CCDS (NCBI)GNAI2
Cluster EST : UnigeneHs.77269 [ NCBI ]
CGAP (NCI)Hs.77269
Alternative Splicing : Fast-db (Paris)GSHG0020817
Alternative Splicing GalleryENSG00000114353
Gene ExpressionGNAI2 [ NCBI-GEO ]     GNAI2 [ SEEK ]   GNAI2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04899 (Uniprot)
NextProtP04899  [Medical]
With graphics : InterProP04899
Splice isoforms : SwissVarP04899 (Swissvar)
Domains : Interpro (EBI)Gprotein_alpha_I [organisation]   Gprotein_alpha_su [organisation]   GproteinA_insert [organisation]   P-loop_NTPase [organisation]  
Related proteins : CluSTrP04899
Domain families : Pfam (Sanger)G-alpha (PF00503)   
Domain families : Pfam (NCBI)pfam00503   
Domain families : Smart (EMBL)G_alpha (SM00275)  
DMDM Disease mutations2771
Blocks (Seattle)P04899
Human Protein AtlasENSG00000114353 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP04899
HPRD00764
IPIIPI00748145   IPI00217906   IPI00926935   IPI01015661   IPI00925504   IPI00924892   IPI00924659   IPI00924427   
Protein Interaction databases
DIP (DOE-UCLA)P04899
IntAct (EBI)P04899
FunCoupENSG00000114353
BioGRIDGNAI2
InParanoidP04899
Interologous Interaction database P04899
IntegromeDBGNAI2
STRING (EMBL)GNAI2
Ontologies - Pathways
Ontology : AmiGOactivation of MAPKK activity  G-protein coupled receptor binding  adenosine receptor signaling pathway  GTPase activity  signal transducer activity  protein binding  GTP binding  nucleus  nucleolus  cytoplasm  centrosome  cytosol  heterotrimeric G-protein complex  plasma membrane  plasma membrane  GTP catabolic process  cell cycle  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  G-protein coupled acetylcholine receptor signaling pathway  gamma-aminobutyric acid signaling pathway  synaptic transmission  response to nutrient  blood coagulation  cell proliferation  positive regulation of cell proliferation  membrane  platelet activation  midbody  G-protein beta/gamma-subunit complex binding  membrane raft  metal ion binding  negative regulation of synaptic transmission  cell division  regulation of calcium ion transport  extracellular vesicular exosome  
Ontology : EGO-EBIactivation of MAPKK activity  G-protein coupled receptor binding  adenosine receptor signaling pathway  GTPase activity  signal transducer activity  protein binding  GTP binding  nucleus  nucleolus  cytoplasm  centrosome  cytosol  heterotrimeric G-protein complex  plasma membrane  plasma membrane  GTP catabolic process  cell cycle  signal transduction  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of adenylate cyclase activity  G-protein coupled acetylcholine receptor signaling pathway  gamma-aminobutyric acid signaling pathway  synaptic transmission  response to nutrient  blood coagulation  cell proliferation  positive regulation of cell proliferation  membrane  platelet activation  midbody  G-protein beta/gamma-subunit complex binding  membrane raft  metal ion binding  negative regulation of synaptic transmission  cell division  regulation of calcium ion transport  extracellular vesicular exosome  
Pathways : KEGGRap1 signaling pathway    Chemokine signaling pathway    Adrenergic signaling in cardiomyocytes    Axon guidance    Tight junction    Gap junction    Leukocyte transendothelial migration    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Long-term depression    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Gastric acid secretion    Parkinson's disease    Cocaine addiction    Morphine addiction    Alcoholism    Pertussis    Chagas disease (American trypanosomiasis)    Toxoplasmosis   
Protein Interaction DatabaseGNAI2
Wikipedia pathwaysGNAI2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GNAI2
snp3D : Map Gene to Disease2771
SNP (GeneSNP Utah)GNAI2
SNP : HGBaseGNAI2
Genetic variants : HAPMAPGNAI2
Exome VariantGNAI2
1000_GenomesGNAI2 
ICGC programENSG00000114353 
Somatic Mutations in Cancer : COSMICGNAI2 
CONAN: Copy Number AnalysisGNAI2 
Mutations and Diseases : HGMDGNAI2
Genomic VariantsGNAI2  GNAI2 [DGVbeta]
dbVarGNAI2
ClinVarGNAI2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM139360    192605   
MedgenGNAI2
GENETestsGNAI2
Disease Genetic AssociationGNAI2
Huge Navigator GNAI2 [HugePedia]  GNAI2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneGNAI2
Homology/Alignments : Family Browser (UCSC)GNAI2
Phylogenetic Trees/Animal Genes : TreeFamGNAI2
Chemical/Protein Interactions : CTD2771
Chemical/Pharm GKB GenePA24347
Clinical trialGNAI2
Cancer Resource (Charite)ENSG00000114353
Other databases
Probes
Litterature
PubMed142 Pubmed reference(s) in Entrez
CoreMineGNAI2
iHOPGNAI2
OncoSearchGNAI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:56:30 CEST 2014

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