GPBAR1 (G protein-coupled bile acid receptor 1)

2007-02-01  

Identity

HGNC
GPBAR1
LOCATION
2q35
LOCUSID
151306
ALIAS
BG37,GPCR19,GPR131,M-BAR,TGR5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 151306
MIM: 610147
HGNC: 19680
Ensembl: ENSG00000179921

Variants:

dbSNP: 151306
ClinVar: 151306
TCGA: ENSG00000179921
COSMIC: GPBAR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179921ENST00000479077Q8TDU6
ENSG00000179921ENST00000519574Q8TDU6
ENSG00000179921ENST00000521462Q8TDU6
ENSG00000179921ENST00000522678Q8TDU6

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
197234932009TGR5-mediated bile acid sensing controls glucose homeostasis.402
125244222003A G protein-coupled receptor responsive to bile acids.364
124193122002Identification of membrane-type receptor for bile acids (M-BAR).239
173261442007The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells.86
199446972010Genome-wide association analysis in primary sclerosing cholangitis.73
225501352012Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease.67
195828122009The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders.61
171788802006Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma.51
230225242012Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells.37
235662002013TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.36

Citation

Dessen P

GPBAR1 (G protein-coupled bile acid receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46065/gpbar1