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GPBAR1 (G protein-coupled bile acid receptor 1)

Identity

Alias (NCBI)BG37
GPCR19
GPR131
M-BAR
TGR5
HGNC (Hugo) GPBAR1
HGNC Alias symbBG37
GPCR
TGR5
M-BAR
GPCR19
GPR131
MGC40597
LocusID (NCBI) 151306
Atlas_Id 46065
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218261015 and ends at 218263861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FMNL2 (2q23.3) / GPBAR1 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GPBAR1   19680
Cards
Entrez_Gene (NCBI)GPBAR1    G protein-coupled bile acid receptor 1
AliasesBG37; GPCR19; GPR131; M-BAR; 
TGR5
GeneCards (Weizmann)GPBAR1
Ensembl hg19 (Hinxton)ENSG00000179921 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179921 [Gene_View]  ENSG00000179921 [Sequence]  chr2:218261015-218263861 [Contig_View]  GPBAR1 [Vega]
ICGC DataPortalENSG00000179921
TCGA cBioPortalGPBAR1
AceView (NCBI)GPBAR1
Genatlas (Paris)GPBAR1
SOURCE (Princeton)GPBAR1
Genetics Home Reference (NIH)GPBAR1
Genomic and cartography
GoldenPath hg38 (UCSC)GPBAR1  -     chr2:218261015-218263861 +  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPBAR1  -     2q35   [Description]    (hg19-Feb_2009)
GoldenPathGPBAR1 - 2q35 [CytoView hg19]  GPBAR1 - 2q35 [CytoView hg38]
ImmunoBaseENSG00000179921
Genome Data Viewer NCBIGPBAR1 [Mapview hg19]  
OMIM610147   
Gene and transcription
Genbank (Entrez)AB086170 AB089307 AK122658 AK122660 BC033625
RefSeq transcript (Entrez)NM_001077191 NM_001077194 NM_001321950 NM_170699
Consensus coding sequences : CCDS (NCBI)GPBAR1
Gene ExpressionGPBAR1 [ NCBI-GEO ]   GPBAR1 [ EBI - ARRAY_EXPRESS ]   GPBAR1 [ SEEK ]   GPBAR1 [ MEM ]
Gene Expression Viewer (FireBrowse)GPBAR1 [ Firebrowse - Broad ]
GenevisibleExpression of GPBAR1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)151306
GTEX Portal (Tissue expression)GPBAR1
Human Protein AtlasENSG00000179921-GPBAR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDU6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDU6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDU6
PhosPhoSitePlusQ8TDU6
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)GPBAR1
PDB (RSDB)7BW0    7CFM    7CFN   
PDB Europe7BW0    7CFM    7CFN   
PDB (PDBSum)7BW0    7CFM    7CFN   
PDB (IMB)7BW0    7CFM    7CFN   
Structural Biology KnowledgeBase7BW0    7CFM    7CFN   
SCOP (Structural Classification of Proteins)7BW0    7CFM    7CFN   
CATH (Classification of proteins structures)7BW0    7CFM    7CFN   
SuperfamilyQ8TDU6
AlphaFold pdb e-kbQ8TDU6   
Human Protein Atlas [tissue]ENSG00000179921-GPBAR1 [tissue]
HPRD17050
Protein Interaction databases
DIP (DOE-UCLA)Q8TDU6
IntAct (EBI)Q8TDU6
BioGRIDGPBAR1
STRING (EMBL)GPBAR1
ZODIACGPBAR1
Ontologies - Pathways
QuickGOQ8TDU6
Ontology : AmiGOnegative regulation of inflammatory response to antigenic stimulus  cytoplasm  plasma membrane  plasma membrane  G protein-coupled receptor signaling pathway  integral component of membrane  bile acid receptor activity  G protein-coupled bile acid receptor activity  G protein-coupled bile acid receptor activity  cell surface bile acid receptor signaling pathway  receptor complex  positive regulation of ERK1 and ERK2 cascade  cellular response to bile acid  positive regulation of cholangiocyte proliferation  regulation of bicellular tight junction assembly  
Ontology : EGO-EBInegative regulation of inflammatory response to antigenic stimulus  cytoplasm  plasma membrane  plasma membrane  G protein-coupled receptor signaling pathway  integral component of membrane  bile acid receptor activity  G protein-coupled bile acid receptor activity  G protein-coupled bile acid receptor activity  cell surface bile acid receptor signaling pathway  receptor complex  positive regulation of ERK1 and ERK2 cascade  cellular response to bile acid  positive regulation of cholangiocyte proliferation  regulation of bicellular tight junction assembly  
NDEx NetworkGPBAR1
Atlas of Cancer Signalling NetworkGPBAR1
Wikipedia pathwaysGPBAR1
Orthology - Evolution
OrthoDB151306
GeneTree (enSembl)ENSG00000179921
Phylogenetic Trees/Animal Genes : TreeFamGPBAR1
Homologs : HomoloGeneGPBAR1
Homology/Alignments : Family Browser (UCSC)GPBAR1
Gene fusions - Rearrangements
Fusion : MitelmanFMNL2/GPBAR1 [2q23.3/2q35]  
Fusion : QuiverGPBAR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPBAR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPBAR1
dbVarGPBAR1
ClinVarGPBAR1
MonarchGPBAR1
1000_GenomesGPBAR1 
Exome Variant ServerGPBAR1
GNOMAD BrowserENSG00000179921
Varsome BrowserGPBAR1
ACMGGPBAR1 variants
VarityQ8TDU6
Genomic Variants (DGV)GPBAR1 [DGVbeta]
DECIPHERGPBAR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPBAR1 
Mutations
ICGC Data PortalGPBAR1 
TCGA Data PortalGPBAR1 
Broad Tumor PortalGPBAR1
OASIS PortalGPBAR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPBAR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGPBAR1
Mutations and Diseases : HGMDGPBAR1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGPBAR1
DgiDB (Drug Gene Interaction Database)GPBAR1
DoCM (Curated mutations)GPBAR1
CIViC (Clinical Interpretations of Variants in Cancer)GPBAR1
Cancer3DGPBAR1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610147   
Orphanet
DisGeNETGPBAR1
MedgenGPBAR1
Genetic Testing Registry GPBAR1
NextProtQ8TDU6 [Medical]
GENETestsGPBAR1
Target ValidationGPBAR1
Huge Navigator GPBAR1 [HugePedia]
ClinGenGPBAR1
Clinical trials, drugs, therapy
MyCancerGenomeGPBAR1
Protein Interactions : CTDGPBAR1
Pharm GKB GenePA134903170
PharosQ8TDU6
Clinical trialGPBAR1
Miscellaneous
canSAR (ICR)GPBAR1
HarmonizomeGPBAR1
DataMed IndexGPBAR1
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGPBAR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:11:15 CEST 2021

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