GPR132 (G protein-coupled receptor 132)

2003-02-01  

Identity

HGNC
GPR132
LOCATION
14q32.33
LOCUSID
29933
ALIAS
G2A

Other Information

Locus ID:

NCBI: 29933
MIM: 606167
HGNC: 17482
Ensembl: ENSG00000183484

Variants:

dbSNP: 29933
ClinVar: 29933
TCGA: ENSG00000183484
COSMIC: GPR132

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183484ENST00000329797Q9UNW8
ENSG00000183484ENST00000392585Q9UNW8
ENSG00000183484ENST00000539291Q9UNW8
ENSG00000183484ENST00000549990A0A0G2JL29
ENSG00000183484ENST00000551869F8VRH8

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
180895682008Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.76
156650782005Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.60
152803852004G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.53
162367152005Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A.47
180341712008G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid.36
280498472017Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.27
125868332003The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.25
174758842007Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A.25
181742302008Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.18
128050232003Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.16

Citation

Dessen P

GPR132 (G protein-coupled receptor 132)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40740/gpr132