GPX4 (glutathione peroxidase 4)

2007-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
GPx-4,GSHPx-4,MCSP,PHGPx,SMDS,snGPx,snPHGPx
FUSION GENES

Other Information

Locus ID:

NCBI: 2879
MIM: 138322
HGNC: 4556
Ensembl: ENSG00000167468

Variants:

dbSNP: 2879
ClinVar: 2879
TCGA: ENSG00000167468
COSMIC: GPX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167468ENST00000354171P36969
ENSG00000167468ENST00000585362R4GNE4
ENSG00000167468ENST00000585480A0A0A0MTT1
ENSG00000167468ENST00000587648K7ERP4
ENSG00000167468ENST00000588919K7EJ20
ENSG00000167468ENST00000589115K7ENB4
ENSG00000167468ENST00000593032K7EKX7
ENSG00000167468ENST00000611653P36969
ENSG00000167468ENST00000614791A0A087X247
ENSG00000167468ENST00000616066A0A087X2I2
ENSG00000167468ENST00000622390A0A087WT12

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Glutathione metabolismKEGGhsa00480
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of 5-eicosatetraenoic acidsREACTOMER-HSA-2142688
Synthesis of 15-eicosatetraenoic acid derivativesREACTOMER-HSA-2142770
Synthesis of 12-eicosatetraenoic acid derivativesREACTOMER-HSA-2142712
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
184833362008Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.41
184833362008Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.41
208520072010Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.41
203786902010Genetic variants in selenoprotein genes increase risk of colorectal cancer.40
296104842018FINO<sub>2</sub> initiates ferroptosis through GPX4 inactivation and iron oxidation.40
176344802007Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.35
176344802007Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.35
184007272008Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex.33

Citation

Dessen P

GPX4 (glutathione peroxidase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45734/gpx4