Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GPX4 (glutathione peroxidase 4)

Identity

Alias_namesglutathione peroxidase 4 (phospholipid hydroperoxidase)
Alias_symbol (synonym)PHGPx
MCSP
Other aliasGPx-4
GSHPx-4
SMDS
snGPx
snPHGPx
HGNC (Hugo) GPX4
LocusID (NCBI) 2879
Atlas_Id 45734
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 1103925 and ends at 1106788 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GPX4 (19p13.3) / SEC63 (6q21)TMEM8A (16p13.3) / GPX4 (19p13.3)TRA2B (3q27.2) / GPX4 (19p13.3)
GPX4 19p13.3 / SEC63 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GPX4   4556
Cards
Entrez_Gene (NCBI)GPX4  2879  glutathione peroxidase 4
AliasesGPx-4; GSHPx-4; MCSP; PHGPx; 
SMDS; snGPx; snPHGPx
GeneCards (Weizmann)GPX4
Ensembl hg19 (Hinxton)ENSG00000167468 [Gene_View]  chr19:1103925-1106788 [Contig_View]  GPX4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000167468 [Gene_View]  chr19:1103925-1106788 [Contig_View]  GPX4 [Vega]
ICGC DataPortalENSG00000167468
TCGA cBioPortalGPX4
AceView (NCBI)GPX4
Genatlas (Paris)GPX4
WikiGenes2879
SOURCE (Princeton)GPX4
Genetics Home Reference (NIH)GPX4
Genomic and cartography
GoldenPath hg19 (UCSC)GPX4  -     chr19:1103925-1106788 +  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GPX4  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblGPX4 - 19p13.3 [CytoView hg19]  GPX4 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIGPX4 [Mapview hg19]  GPX4 [Mapview hg38]
OMIM138322   
Gene and transcription
Genbank (Entrez)AI274351 AK225859 AL558552 BC010157 BC011836
RefSeq transcript (Entrez)NM_001039847 NM_001039848 NM_002085
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)GPX4
Cluster EST : UnigeneHs.433951 [ NCBI ]
CGAP (NCI)Hs.433951
Alternative Splicing GalleryENSG00000167468
Gene ExpressionGPX4 [ NCBI-GEO ]   GPX4 [ EBI - ARRAY_EXPRESS ]   GPX4 [ SEEK ]   GPX4 [ MEM ]
Gene Expression Viewer (FireBrowse)GPX4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2879
GTEX Portal (Tissue expression)GPX4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36969   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36969  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36969
Splice isoforms : SwissVarP36969
Catalytic activity : Enzyme1.11.1.12 [ Enzyme-Expasy ]   1.11.1.121.11.1.12 [ IntEnz-EBI ]   1.11.1.12 [ BRENDA ]   1.11.1.12 [ KEGG ]   
PhosPhoSitePlusP36969
Domaine pattern : Prosite (Expaxy)GLUTATHIONE_PEROXID_1 (PS00460)    GLUTATHIONE_PEROXID_2 (PS00763)    GLUTATHIONE_PEROXID_3 (PS51355)   
Domains : Interpro (EBI)Glutathione_peroxidase    GPX_AS    GPX_CS    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)GSHPx (PF00255)   
Domain families : Pfam (NCBI)pfam00255   
Conserved Domain (NCBI)GPX4
DMDM Disease mutations2879
Blocks (Seattle)GPX4
PDB (SRS)2GS3    2OBI   
PDB (PDBSum)2GS3    2OBI   
PDB (IMB)2GS3    2OBI   
PDB (RSDB)2GS3    2OBI   
Structural Biology KnowledgeBase2GS3    2OBI   
SCOP (Structural Classification of Proteins)2GS3    2OBI   
CATH (Classification of proteins structures)2GS3    2OBI   
SuperfamilyP36969
Human Protein AtlasENSG00000167468
Peptide AtlasP36969
HPRD11819
IPIIPI00304814   IPI00745335   IPI00745800   IPI00884192   
Protein Interaction databases
DIP (DOE-UCLA)P36969
IntAct (EBI)P36969
FunCoupENSG00000167468
BioGRIDGPX4
STRING (EMBL)GPX4
ZODIACGPX4
Ontologies - Pathways
QuickGOP36969
Ontology : AmiGOglutathione peroxidase activity  nucleus  mitochondrion  cytosol  phospholipid metabolic process  response to oxidative stress  multicellular organism development  lipoxygenase pathway  phospholipid-hydroperoxide glutathione peroxidase activity  oxidation-reduction process  extracellular exosome  cellular oxidant detoxification  cellular oxidant detoxification  
Ontology : EGO-EBIglutathione peroxidase activity  nucleus  mitochondrion  cytosol  phospholipid metabolic process  response to oxidative stress  multicellular organism development  lipoxygenase pathway  phospholipid-hydroperoxide glutathione peroxidase activity  oxidation-reduction process  extracellular exosome  cellular oxidant detoxification  cellular oxidant detoxification  
Pathways : KEGGGlutathione metabolism   
NDEx NetworkGPX4
Atlas of Cancer Signalling NetworkGPX4
Wikipedia pathwaysGPX4
Orthology - Evolution
OrthoDB2879
GeneTree (enSembl)ENSG00000167468
Phylogenetic Trees/Animal Genes : TreeFamGPX4
HOVERGENP36969
HOGENOMP36969
Homologs : HomoloGeneGPX4
Homology/Alignments : Family Browser (UCSC)GPX4
Gene fusions - Rearrangements
Fusion : MitelmanGPX4/SEC63 [19p13.3/6q21]  
Fusion: TCGAGPX4 19p13.3 SEC63 6q21 THCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPX4
dbVarGPX4
ClinVarGPX4
1000_GenomesGPX4 
Exome Variant ServerGPX4
ExAC (Exome Aggregation Consortium)GPX4 (select the gene name)
Genetic variants : HAPMAP2879
Genomic Variants (DGV)GPX4 [DGVbeta]
DECIPHER (Syndromes)19:1103925-1106788  ENSG00000167468
CONAN: Copy Number AnalysisGPX4 
Mutations
ICGC Data PortalGPX4 
TCGA Data PortalGPX4 
Broad Tumor PortalGPX4
OASIS PortalGPX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPX4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GPX4
DgiDB (Drug Gene Interaction Database)GPX4
DoCM (Curated mutations)GPX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPX4 (select a term)
intoGenGPX4
Cancer3DGPX4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138322   
Orphanet12254   
MedgenGPX4
Genetic Testing Registry GPX4
NextProtP36969 [Medical]
TSGene2879
GENETestsGPX4
Huge Navigator GPX4 [HugePedia]
snp3D : Map Gene to Disease2879
BioCentury BCIQGPX4
ClinGenGPX4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2879
Chemical/Pharm GKB GenePA28952
Clinical trialGPX4
Miscellaneous
canSAR (ICR)GPX4 (select the gene name)
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPX4
EVEXGPX4
GoPubMedGPX4
iHOPGPX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:08:07 CET 2017

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