GPX4 (glutathione peroxidase 4 (phospholipid hydroperoxidase))

Identity

Other names	MCSP
	PHGPx
	snGPx
	snPHGPx
HGNC	GPX4
Location	19p13.3
Location_base_pair	Starts at 1054936 and ends at 1057787 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	GPX4   4556
Entrez_Gene	GPX4  2879  glutathione peroxidase 4 (phospholipid hydroperoxidase)
	Cards
GeneCards	GPX4
Ensembl	GPX4 [Search_View]   ENSG00000167468 [Gene_View]
Genatlas	GPX4
GeneLynx	GPX4
eGenome	GPX4
euGene	2879
	Genomic and cartography
GoldenPath	GPX4  -  19p13.3   chr19:1054936-1057787 +  19p13.3   [Description]    (hg18-March_2006)
Ensembl	GPX4 - 19p13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	GPX4
	Gene and transcription
Genbank	AK225859 [ ENTREZ ]
Genbank	BC010157 [ ENTREZ ]
Genbank	BC011836 [ ENTREZ ]
Genbank	BC021567 [ ENTREZ ]
Genbank	BC022071 [ ENTREZ ]
RefSeq	NM_001039847 [ SRS ]    NM_001039847 [ ENTREZ ]
RefSeq	NM_001039848 [ SRS ]    NM_001039848 [ ENTREZ ]
RefSeq	NM_002085 [ SRS ]    NM_002085 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NT_011255 [ SRS ]    NT_011255 [ ENTREZ ]
RefSeq	NW_001838476 [ SRS ]    NW_001838476 [ ENTREZ ]
RefSeq	NW_927173 [ SRS ]    NW_927173 [ ENTREZ ]
AceView	GPX4 AceView - NCBI
Unigene	Hs.433951 [ SRS ]    Hs.433951 [ NCBI ]     HS433951 [ spliceNest ]
Fast-db	974 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P36969 [ SRS]    P36969 [ EXPASY ]     P36969 [ INTERPRO ]     P36969 [ UNIPROT ]
Prosite	PS00460 GLUTATHIONE_PEROXID_1 [ SRS ]    PS00460 GLUTATHIONE_PEROXID_1 [ Expasy ]
Prosite	PS00763 GLUTATHIONE_PEROXID_2 [ SRS ]    PS00763 GLUTATHIONE_PEROXID_2 [ Expasy ]
Prosite	PS51355 GLUTATHIONE_PEROXID_3 [ SRS ]    PS51355 GLUTATHIONE_PEROXID_3 [ Expasy ]
Interpro	IPR000889 Glut_peroxidase [ SRS ]    IPR000889 Glut_peroxidase [ EBI ]
Interpro	IPR012335 Thioredoxin_fold [ SRS ]    IPR012335 Thioredoxin_fold [ EBI ]
CluSTr	P36969
Pfam	PF00255 GSHPx [ SRS ]    PF00255 GSHPx [ Sanger ]    pfam00255 [ NCBI-CDD ]
Blocks	P36969
PDB	2GS3 [ SRS ]    2GS3 [ PdbSum ],   2GS3 [ IMB ]   2GS3 [ RSDB ]
PDB	2OBI [ SRS ]    2OBI [ PdbSum ],   2OBI [ IMB ]   2OBI [ RSDB ]
HPRD	11819
	Protein Interaction databases
DIP	P36969
IntAct	P36969
	Polymorphism : SNP, mutations, diseases
OMIM	138322    [ map ]
GENECLINICS	138322
SNP	GPX4 [dbSNP-NCBI]
SNP	NM_001039847 [SNP-NCI]
SNP	NM_001039848 [SNP-NCI]
SNP	NM_002085 [SNP-NCI]
SNP	GPX4 [GeneSNPs - Utah]  GPX4] [HGBASE - SRS]
HAPMAP	GPX4 [HAPMAP]
HGMD	GPX4
	General knowledge
Family Browser	GPX4 [UCSC Family Browser]
SOURCE	NM_001039847
SOURCE	NM_001039848
SOURCE	NM_002085
SMD	Hs.433951
SAGE	Hs.433951
Enzyme	1.11.1.12 [ Enzyme-Expasy ]   1.11.1.12 [ Enzyme-SRS ]   1.11.1.12 [ IntEnz-EBI ]   1.11.1.12 [ BRENDA ]   1.11.1.12 [ KEGG ]   1.11.1.12 [ WIT ]
GO	glutathione peroxidase activity [Amigo]  glutathione peroxidase activity
GO	glutathione peroxidase activity [Amigo]  glutathione peroxidase activity
GO	soluble fraction [Amigo]  soluble fraction
GO	nucleus [Amigo]  nucleus
GO	nuclear envelope [Amigo]  nuclear envelope
GO	cytoplasm [Amigo]  cytoplasm
GO	mitochondrion [Amigo]  mitochondrion
GO	mitochondrial inner membrane [Amigo]  mitochondrial inner membrane
GO	cytosol [Amigo]  cytosol
GO	establishment and/or maintenance of chromatin architecture [Amigo]  establishment and/or maintenance of chromatin architecture
GO	phospholipid metabolic process [Amigo]  phospholipid metabolic process
GO	glutathione metabolic process [Amigo]  glutathione metabolic process
GO	response to oxidative stress [Amigo]  response to oxidative stress
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	spermatogenesis [Amigo]  spermatogenesis
GO	selenium binding [Amigo]  selenium binding
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	hydrogen peroxide catabolic process [Amigo]  hydrogen peroxide catabolic process
GO	glutathione binding [Amigo]  glutathione binding
GO	phospholipid-hydroperoxide glutathione peroxidase activity [Amigo]  phospholipid-hydroperoxide glutathione peroxidase activity
GO	regulation of inflammatory response [Amigo]  regulation of inflammatory response
GO	oxidation reduction [Amigo]  oxidation reduction
KEGG	Glutathione metabolism
KEGG	Arachidonic acid metabolism
PubGene	GPX4
TreeFam	GPX4
CTD	2879 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	GPX4 Related clones (RZPD - Berlin)
	PubMed
PubMed	41 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:43:46 2008