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GSR (glutathione reductase)

Identity

Other names-
HGNC (Hugo) GSR
LocusID (NCBI) 2936
Location 8p12
Location_base_pair Starts at 30535580 and ends at 30585486 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GSR   4623
Cards
Entrez_Gene (NCBI)GSR  2936  glutathione reductase
GeneCards (Weizmann)GSR
Ensembl (Hinxton)ENSG00000104687 [Gene_View]  chr8:30535580-30585486 [Contig_View]  GSR [Vega]
AceView (NCBI)GSR
Genatlas (Paris)GSR
WikiGenes2936
SOURCE (Princeton)NM_000637 NM_001195102 NM_001195103 NM_001195104
Genomic and cartography
GoldenPath (UCSC)GSR  -  8p12   chr8:30535580-30585486 -  8p12   [Description]    (hg19-Feb_2009)
EnsemblGSR - 8p12 [CytoView]
Mapping of homologs : NCBIGSR [Mapview]
OMIM138300   
Gene and transcription
Genbank (Entrez)AB519179 AB519180 AB519181 AF228704 BC035691
RefSeq transcript (Entrez)NM_000637 NM_001195102 NM_001195103 NM_001195104
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_027719 NT_167187 NW_001839128 NW_004929337
Consensus coding sequences : CCDS (NCBI)GSR
Cluster EST : UnigeneHs.271510 [ NCBI ]
CGAP (NCI)Hs.271510
Alternative Splicing : Fast-db (Paris)GSHG0029512
Alternative Splicing GalleryENSG00000104687
Gene ExpressionGSR [ NCBI-GEO ]     GSR [ SEEK ]   GSR [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00390 (Uniprot)
NextProtP00390  [Medical]
With graphics : InterProP00390
Splice isoforms : SwissVarP00390 (Swissvar)
Catalytic activity : Enzyme1.8.1.7 [ Enzyme-Expasy ]   1.8.1.71.8.1.7 [ IntEnz-EBI ]   1.8.1.7 [ BRENDA ]   1.8.1.7 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PYRIDINE_REDOX_1 (PS00076)   
Domains : Interpro (EBI)FAD/NAD-linked_Rdtase_dimer    FAD_pyr_nucl-diS_OxRdtase    Glutathione_Rdtase_euk/bac    Pyr_nucl-diS_OxRdtase_dimer    Pyr_nucl-diS_OxRdtase_FAD/NAD    Pyr_OxRdtase_I_AS    Pyr_OxRdtase_NAD-bd_dom   
Related proteins : CluSTrP00390
Domain families : Pfam (Sanger)Pyr_redox (PF00070)    Pyr_redox_2 (PF07992)    Pyr_redox_dim (PF02852)   
Domain families : Pfam (NCBI)pfam00070    pfam07992    pfam02852   
DMDM Disease mutations2936
Blocks (Seattle)P00390
PDB (SRS)1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
PDB (PDBSum)1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
PDB (IMB)1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
PDB (RSDB)1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
Human Protein AtlasENSG00000104687
Peptide AtlasP00390
HPRD00704
IPIIPI00016862   IPI00759575   IPI00953236   IPI00978634   IPI00953696   IPI01011936   
Protein Interaction databases
DIP (DOE-UCLA)P00390
IntAct (EBI)P00390
FunCoupENSG00000104687
BioGRIDGSR
InParanoidP00390
Interologous Interaction database P00390
IntegromeDBGSR
STRING (EMBL)GSR
Ontologies - Pathways
Ontology : AmiGOglutathione-disulfide reductase activity  mitochondrion  cytosol  glutathione metabolic process  electron carrier activity  nucleobase-containing small molecule interconversion  small molecule metabolic process  cell redox homeostasis  flavin adenine dinucleotide binding  NADP binding  nucleobase-containing small molecule metabolic process  
Ontology : EGO-EBIglutathione-disulfide reductase activity  mitochondrion  cytosol  glutathione metabolic process  electron carrier activity  nucleobase-containing small molecule interconversion  small molecule metabolic process  cell redox homeostasis  flavin adenine dinucleotide binding  NADP binding  nucleobase-containing small molecule metabolic process  
Pathways : BIOCARTAFree Radical Induced Apoptosis [Genes]   
Pathways : KEGGGlutathione metabolism    Thyroid hormone synthesis   
REACTOMEGSR
Protein Interaction DatabaseGSR
Wikipedia pathwaysGSR
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GSR
SNP (GeneSNP Utah)GSR
SNP : HGBaseGSR
Genetic variants : HAPMAPGSR
1000_GenomesGSR 
ICGC programENSG00000104687 
Somatic Mutations in Cancer : COSMICGSR 
CONAN: Copy Number AnalysisGSR 
Mutations and Diseases : HGMDGSR
OMIM138300   
GENETestsGSR
Disease Genetic AssociationGSR
Huge Navigator GSR [HugePedia]  GSR [HugeCancerGEM]
Genomic VariantsGSR  GSR [DGVbeta]
Exome VariantGSR
dbVarGSR
ClinVarGSR
snp3D : Map Gene to Disease2936
General knowledge
Homologs : HomoloGeneGSR
Homology/Alignments : Family Browser (UCSC)GSR
Phylogenetic Trees/Animal Genes : TreeFamGSR
Chemical/Protein Interactions : CTD2936
Chemical/Pharm GKB GenePA29014
Clinical trialGSR
Cancer Resource (Charite)ENSG00000104687
Other databases
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
CoreMineGSR
iHOPGSR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 16:49:52 CEST 2014

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