GSR (glutathione-disulfide reductase)

2003-08-01  

Identity

HGNC
GSR
LOCATION
8p12
LOCUSID
2936
ALIAS
GR,GSRD,HEL-75,HEL-S-122m
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2936
MIM: 138300
HGNC: 4623
Ensembl: ENSG00000104687

Variants:

dbSNP: 2936
ClinVar: 2936
TCGA: ENSG00000104687
COSMIC: GSR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104687ENST00000221130P00390
ENSG00000104687ENST00000221130V9HW90
ENSG00000104687ENST00000523295H0YC68
ENSG00000104687ENST00000537535P00390
ENSG00000104687ENST00000541648P00390
ENSG00000104687ENST00000546342P00390
ENSG00000104687ENST00000643653A0A2R8YF59

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Glutathione metabolismKEGGhsa00480
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested H2SeO4 and H2SeO3 into H2SeREACTOMER-HSA-2408550

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA150481189taxanesChemicalClinicalAnnotationassociatedPD26194361
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPD26194361
PA448803carboplatinChemicalClinicalAnnotationassociatedPD26194361

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
237703632013Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes.34
195277002009Antioxidative enzymes and increased oxidative stress in depressive women.32
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
164240622006Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.25
186384832008Catalytic cycle of human glutathione reductase near 1 A resolution.22
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.22
189772412008Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.20
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.20

Citation

Dessen P

GSR (glutathione-disulfide reductase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40763/gsr