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GSR (glutathione-disulfide reductase)

Identity

Alias (NCBI)GR
GSRD
HEL-75
HEL-S-122m
HGNC (Hugo) GSR
HGNC Alias nameglutathione S-reductase
HGNC Previous nameglutathione reductase
LocusID (NCBI) 2936
Atlas_Id 40763
Location 8p12  [Link to chromosome band 8p12]
Location_base_pair Starts at 30678063 and ends at 30727999 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GTF2E2 (8p12)::GSR (8p12)TRIM35 (8p21.2)::GSR (8p12)GTF2E2 8p12::GSR 8p12
TRIM35 8p21.2::GSR 8p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GSR   4623
LRG (Locus Reference Genomic)LRG_1167
Cards
Entrez_Gene (NCBI)GSR    glutathione-disulfide reductase
AliasesGR; GSRD; HEL-75; HEL-S-122m
GeneCards (Weizmann)GSR
Ensembl hg19 (Hinxton)ENSG00000104687 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104687 [Gene_View]  ENSG00000104687 [Sequence]  chr8:30678063-30727999 [Contig_View]  GSR [Vega]
ICGC DataPortalENSG00000104687
TCGA cBioPortalGSR
AceView (NCBI)GSR
Genatlas (Paris)GSR
SOURCE (Princeton)GSR
Genetics Home Reference (NIH)GSR
Genomic and cartography
GoldenPath hg38 (UCSC)GSR  -     chr8:30678063-30727999 -  8p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GSR  -     8p12   [Description]    (hg19-Feb_2009)
GoldenPathGSR - 8p12 [CytoView hg19]  GSR - 8p12 [CytoView hg38]
ImmunoBaseENSG00000104687
Genome Data Viewer NCBIGSR [Mapview hg19]  
OMIM138300   618660   
Gene and transcription
Genbank (Entrez)AB519179 AB519180 AB519181 AF228704 BC035691
RefSeq transcript (Entrez)NM_000637 NM_001195102 NM_001195103 NM_001195104
Consensus coding sequences : CCDS (NCBI)GSR
Gene ExpressionGSR [ NCBI-GEO ]   GSR [ EBI - ARRAY_EXPRESS ]   GSR [ SEEK ]   GSR [ MEM ]
Gene Expression Viewer (FireBrowse)GSR [ Firebrowse - Broad ]
GenevisibleExpression of GSR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2936
GTEX Portal (Tissue expression)GSR
Human Protein AtlasENSG00000104687-GSR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00390   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00390  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00390
PhosPhoSitePlusP00390
Domaine pattern : Prosite (Expaxy)PYRIDINE_REDOX_1 (PS00076)   
Domains : Interpro (EBI)FAD/NAD-bd_sf    FAD/NAD-binding_dom    FAD/NAD-linked_Rdtase_dimer_sf    Glutathione_Rdtase_euk/bac    Pyr_nuc-diS_OxRdtase    Pyr_nucl-diS_OxRdtase_dimer    Pyr_OxRdtase_I_AS   
Domain families : Pfam (Sanger)Pyr_redox_2 (PF07992)    Pyr_redox_dim (PF02852)   
Domain families : Pfam (NCBI)pfam07992    pfam02852   
Conserved Domain (NCBI)GSR
PDB (RSDB)1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
PDB Europe1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
PDB (PDBSum)1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
PDB (IMB)1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
Structural Biology KnowledgeBase1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
SCOP (Structural Classification of Proteins)1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
CATH (Classification of proteins structures)1ALG    1BWC    1DNC    1GRA    1GRB    1GRE    1GRF    1GRG    1GRH    1GRT    1GSN    1K4Q    1XAN    2AAQ    2GH5    2GRT    3DJG    3DJJ    3DK4    3DK8    3DK9    3GRS    3GRT    3SQP    4GR1    4GRT    5GRT   
SuperfamilyP00390
AlphaFold pdb e-kbP00390   
Human Protein Atlas [tissue]ENSG00000104687-GSR [tissue]
HPRD00704
Protein Interaction databases
DIP (DOE-UCLA)P00390
IntAct (EBI)P00390
BioGRIDGSR
STRING (EMBL)GSR
ZODIACGSR
Ontologies - Pathways
QuickGOP00390
Ontology : AmiGOglutathione-disulfide reductase (NADPH) activity  mitochondrion  mitochondrial matrix  cytosol  cytosol  cytosol  glutathione metabolic process  electron transfer activity  external side of plasma membrane  nucleobase-containing small molecule interconversion  electron transport chain  cellular response to oxidative stress  cellular response to oxidative stress  cell redox homeostasis  flavin adenine dinucleotide binding  NADP binding  extracellular exosome  cellular oxidant detoxification  
Ontology : EGO-EBIglutathione-disulfide reductase (NADPH) activity  mitochondrion  mitochondrial matrix  cytosol  cytosol  cytosol  glutathione metabolic process  electron transfer activity  external side of plasma membrane  nucleobase-containing small molecule interconversion  electron transport chain  cellular response to oxidative stress  cellular response to oxidative stress  cell redox homeostasis  flavin adenine dinucleotide binding  NADP binding  extracellular exosome  cellular oxidant detoxification  
Pathways : BIOCARTAFree Radical Induced Apoptosis [Genes]   
Pathways : KEGGGlutathione metabolism    Thyroid hormone synthesis   
NDEx NetworkGSR
Atlas of Cancer Signalling NetworkGSR
Wikipedia pathwaysGSR
Orthology - Evolution
OrthoDB2936
GeneTree (enSembl)ENSG00000104687
Phylogenetic Trees/Animal Genes : TreeFamGSR
Homologs : HomoloGeneGSR
Homology/Alignments : Family Browser (UCSC)GSR
Gene fusions - Rearrangements
Fusion : MitelmanTRIM35::GSR [8p21.2/8p12]  
Fusion : QuiverGSR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSR
dbVarGSR
ClinVarGSR
MonarchGSR
1000_GenomesGSR 
Exome Variant ServerGSR
GNOMAD BrowserENSG00000104687
Varsome BrowserGSR
ACMGGSR variants
VarityP00390
Genomic Variants (DGV)GSR [DGVbeta]
DECIPHERGSR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGSR 
Mutations
ICGC Data PortalGSR 
TCGA Data PortalGSR 
Broad Tumor PortalGSR
OASIS PortalGSR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGSR
Mutations and Diseases : HGMDGSR
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGSR
DgiDB (Drug Gene Interaction Database)GSR
DoCM (Curated mutations)GSR
CIViC (Clinical Interpretations of Variants in Cancer)GSR
Cancer3DGSR
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138300    618660   
Orphanet11929   
DisGeNETGSR
MedgenGSR
Genetic Testing Registry GSR
NextProtP00390 [Medical]
GENETestsGSR
Target ValidationGSR
Huge Navigator GSR [HugePedia]
ClinGenGSR
Clinical trials, drugs, therapy
MyCancerGenomeGSR
Protein Interactions : CTDGSR
Pharm GKB GenePA29014
Pharm GKB PathwaysPA165980399   
PharosP00390
Clinical trialGSR
Miscellaneous
canSAR (ICR)GSR
HarmonizomeGSR
ARCHS4GSR
DataMed IndexGSR
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGSR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:13:17 CET 2022

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