GSTT1 (glutathione S-transferase theta 1)

2003-02-01 Affiliation

Identity

HGNC

GSTT1

LOCATION

22q11.23

LOCUSID

2952

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2952
MIM: 600436
HGNC: 4641

Variants:

dbSNP: 2952
ClinVar: 2952
COSMIC: GSTT1

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Glutathione metabolism	KEGG	hsa00480
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glutathione conjugation	REACTOME	R-HSA-156590
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10804	imatinib	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	25188725
PA10832	corticosteroids	Chemical	VariantAnnotation	not associated		PD	26644204
PA130232992	bevacizumab	Chemical	VariantAnnotation	not associated		PD	27995989
PA131285527	oxaliplatin	Chemical	VariantAnnotation	not associated		PD	27995989
PA162263534	Ototoxicity	Disease	ClinicalAnnotation	associated		PD	17228018, 23274376, 26571237, 26803611
PA162316739	Maculopapular Exanthema	Disease	VariantAnnotation	not associated		PD	20036620
PA164712505	Antivirals for treatment of HIV infections, combinations	Chemical	VariantAnnotation	not associated		PD	26667829
PA164712708	Drugs For Treatment Of Tuberculosis	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA164713176	Platinum compounds	Chemical	VariantAnnotation, VipGene	ambiguous		PD	26803611
PA164784021	ethambutol	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA164925725	Toxic liver disease	Disease	VariantAnnotation	ambiguous		PD	11595069, 18397238, 21753138, 22335459, 24637014, 26667829, 28689274
PA166048678	GSTT1 null	Haplotype	VipGene	associated			10801254, 10975610, 11018744, 11447041, 11595069, 11840286, 12172391, 12732844, 14740231, 15882759, 17000715, 17400324, 17438538, 18065725, 19102712, 19143011, 19863340, 20303013, 20385995, 20977336, 21343247, 21436184, 21640195, 21765044, 7954469, 10625170
PA166122986	radiotherapy	Chemical	VariantAnnotation	not associated		PD
PA166179129	exacerbation of asthma	Disease	VariantAnnotation	associated			29785881
PA443450	Asthma	Disease	VariantAnnotation	associated			29785881
PA443685	Uterine Cervical Neoplasms	Disease	VariantAnnotation	not associated		PD
PA443840	Deafness	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	17228018, 23274376, 26571237, 26803611
PA443842	Death	Disease	VariantAnnotation	not associated		PD
PA443937	Drug Toxicity	Disease	VariantAnnotation	not associated		PD	22845549, 26644204, 27995989
PA444059	Epidermal Necrolysis, Toxic	Disease	VariantAnnotation	not associated		PD	28689274
PA444109	Exanthema	Disease	VipGene	associated			14740231
PA444442	Hepatitis, Toxic	Disease	VariantAnnotation	not associated		PD	20036620, 20853551, 22012226
PA444485	Hodgkin Disease	Disease	VariantAnnotation	not associated		PD	23323945
PA444985	Multiple Myeloma	Disease	ClinicalAnnotation	associated		PD	21435719
PA445062	Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	17228018, 23274376, 26571237, 26803611
PA445113	Neutropenia	Disease	VariantAnnotation	associated		PD	27168101
PA445204	Ovarian Neoplasms	Disease	VariantAnnotation	not associated		PD	26803611
PA445506	Recurrence	Disease	VariantAnnotation	not associated		PD
PA445738	Stevens-Johnson Syndrome	Disease	VariantAnnotation	not associated		PD	28689274
PA445742	Stomach Neoplasms	Disease	VariantAnnotation	not associated		PD	27995989
PA445828	Testicular Neoplasms	Disease	VariantAnnotation	not associated		PD	17228018
PA445941	Tuberculosis	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Disease	VariantAnnotation	not associated		PD	26644204
PA446171	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	25188725
PA447230	HIV	Disease	VariantAnnotation	not associated		PD	26667829, 28689274
PA448406	amoxicillin	Chemical	VipGene	associated
PA448515	azathioprine	Chemical	MultilinkAnnotation	not associated			23787247
PA448645	bleomycin	Chemical	VariantAnnotation	not associated		PD	23323945
PA448771	capecitabine	Chemical	VariantAnnotation	not associated		PD	27995989
PA448803	carboplatin	Chemical	VipGene	associated
PA449014	cisplatin	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous		PD	17228018, 23274376, 26571237, 26803611, 27995989
PA449061	clozapine	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	27168101
PA449197	dacarbazine	Chemical	VariantAnnotation	not associated		PD	23323945
PA449383	docetaxel	Chemical	VariantAnnotation	not associated		PD	27995989
PA449412	doxorubicin	Chemical	VariantAnnotation	not associated		PD	23323945
PA449476	epirubicin	Chemical	VariantAnnotation	not associated		PD	27995989
PA449552	etoposide	Chemical	VipGene	associated
PA450112	isoniazid	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA450616	nevirapine	Chemical	VariantAnnotation	not associated		PD	28689274
PA450761	paclitaxel	Chemical	VariantAnnotation	not associated		PD	26803611
PA451182	pyrazinamide	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA451250	rifampin	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA451512	streptomycin	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014
PA451644	thalidomide	Chemical	ClinicalAnnotation	associated		PD	21435719
PA451743	trastuzumab	Chemical	VariantAnnotation	not associated		PD	27995989
PA451799	troglitazone	Chemical	VipGene	associated			12732844
PA451846	valproic acid	Chemical	VariantAnnotation	not associated		PD
PA451877	vinblastine	Chemical	VariantAnnotation	not associated		PD	23323945
PA452604	xenobiotics	Chemical	VipGene	associated			9285043, 9851677, 11317340
PA452621	antineoplastic agents	Chemical	VariantAnnotation	not associated		PD	26644204

References

Pubmed ID	Year	Title	Citations
16112301	2005	NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.	174
11751440	2001	Metabolic gene polymorphism frequencies in control populations.	157
11779261	2002	Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight.	157
15113959	2004	Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype.	83
15113959	2004	Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype.	83
15746160	2005	Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer.	83
14726165	2004	Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study.	82
17401013	2007	Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy.	77
15213713	2004	A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer.	75
12072547	2002	Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer.	65

Citation

Dessen P

GSTT1 (glutathione S-transferase theta 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40774/gstt1