Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2952
MIM: 600436
HGNC: 4641
Variants:
dbSNP: 2952
ClinVar: 2952
COSMIC: GSTT1
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10804 | imatinib | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 25188725 | |
| PA10832 | corticosteroids | Chemical | VariantAnnotation | not associated | PD | 26644204 | |
| PA130232992 | bevacizumab | Chemical | VariantAnnotation | not associated | PD | 27995989 | |
| PA131285527 | oxaliplatin | Chemical | VariantAnnotation | not associated | PD | 27995989 | |
| PA162263534 | Ototoxicity | Disease | ClinicalAnnotation | associated | PD | 17228018, 23274376, 26571237, 26803611 | |
| PA162316739 | Maculopapular Exanthema | Disease | VariantAnnotation | not associated | PD | 20036620 | |
| PA164712505 | Antivirals for treatment of HIV infections, combinations | Chemical | VariantAnnotation | not associated | PD | 26667829 | |
| PA164712708 | Drugs For Treatment Of Tuberculosis | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014 |
| PA164713176 | Platinum compounds | Chemical | VariantAnnotation, VipGene | ambiguous | PD | 26803611 | |
| PA164784021 | ethambutol | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014 |
| PA164925725 | Toxic liver disease | Disease | VariantAnnotation | ambiguous | PD | 11595069, 18397238, 21753138, 22335459, 24637014, 26667829, 28689274 | |
| PA166048678 | GSTT1 null | Haplotype | VipGene | associated | 10801254, 10975610, 11018744, 11447041, 11595069, 11840286, 12172391, 12732844, 14740231, 15882759, 17000715, 17400324, 17438538, 18065725, 19102712, 19143011, 19863340, 20303013, 20385995, 20977336, 21343247, 21436184, 21640195, 21765044, 7954469, 10625170 | ||
| PA166122986 | radiotherapy | Chemical | VariantAnnotation | not associated | PD | ||
| PA166179129 | exacerbation of asthma | Disease | VariantAnnotation | associated | 29785881 | ||
| PA443450 | Asthma | Disease | VariantAnnotation | associated | 29785881 | ||
| PA443685 | Uterine Cervical Neoplasms | Disease | VariantAnnotation | not associated | PD | ||
| PA443840 | Deafness | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 17228018, 23274376, 26571237, 26803611 | |
| PA443842 | Death | Disease | VariantAnnotation | not associated | PD | ||
| PA443937 | Drug Toxicity | Disease | VariantAnnotation | not associated | PD | 22845549, 26644204, 27995989 | |
| PA444059 | Epidermal Necrolysis, Toxic | Disease | VariantAnnotation | not associated | PD | 28689274 | |
| PA444109 | Exanthema | Disease | VipGene | associated | 14740231 | ||
| PA444442 | Hepatitis, Toxic | Disease | VariantAnnotation | not associated | PD | 20036620, 20853551, 22012226 | |
| PA444485 | Hodgkin Disease | Disease | VariantAnnotation | not associated | PD | 23323945 | |
| PA444985 | Multiple Myeloma | Disease | ClinicalAnnotation | associated | PD | 21435719 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 17228018, 23274376, 26571237, 26803611 | |
| PA445113 | Neutropenia | Disease | VariantAnnotation | associated | PD | 27168101 | |
| PA445204 | Ovarian Neoplasms | Disease | VariantAnnotation | not associated | PD | 26803611 | |
| PA445506 | Recurrence | Disease | VariantAnnotation | not associated | PD | ||
| PA445738 | Stevens-Johnson Syndrome | Disease | VariantAnnotation | not associated | PD | 28689274 | |
| PA445742 | Stomach Neoplasms | Disease | VariantAnnotation | not associated | PD | 27995989 | |
| PA445828 | Testicular Neoplasms | Disease | VariantAnnotation | not associated | PD | 17228018 | |
| PA445941 | Tuberculosis | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014 |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Disease | VariantAnnotation | not associated | PD | 26644204 | |
| PA446171 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 25188725 | |
| PA447230 | HIV | Disease | VariantAnnotation | not associated | PD | 26667829, 28689274 | |
| PA448406 | amoxicillin | Chemical | VipGene | associated | |||
| PA448515 | azathioprine | Chemical | MultilinkAnnotation | not associated | 23787247 | ||
| PA448645 | bleomycin | Chemical | VariantAnnotation | not associated | PD | 23323945 | |
| PA448771 | capecitabine | Chemical | VariantAnnotation | not associated | PD | 27995989 | |
| PA448803 | carboplatin | Chemical | VipGene | associated | |||
| PA449014 | cisplatin | Chemical | ClinicalAnnotation, VariantAnnotation, VipGene | ambiguous | PD | 17228018, 23274376, 26571237, 26803611, 27995989 | |
| PA449061 | clozapine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 27168101 | |
| PA449197 | dacarbazine | Chemical | VariantAnnotation | not associated | PD | 23323945 | |
| PA449383 | docetaxel | Chemical | VariantAnnotation | not associated | PD | 27995989 | |
| PA449412 | doxorubicin | Chemical | VariantAnnotation | not associated | PD | 23323945 | |
| PA449476 | epirubicin | Chemical | VariantAnnotation | not associated | PD | 27995989 | |
| PA449552 | etoposide | Chemical | VipGene | associated | |||
| PA450112 | isoniazid | Chemical | ClinicalAnnotation, VariantAnnotation, VipGene | ambiguous | PK | PD | 11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014 |
| PA450616 | nevirapine | Chemical | VariantAnnotation | not associated | PD | 28689274 | |
| PA450761 | paclitaxel | Chemical | VariantAnnotation | not associated | PD | 26803611 | |
| PA451182 | pyrazinamide | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014 |
| PA451250 | rifampin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014 |
| PA451512 | streptomycin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 11595069, 18397238, 18544910, 20036620, 20853551, 21753138, 22012226, 22335459, 22788240, 22845549, 24637014 |
| PA451644 | thalidomide | Chemical | ClinicalAnnotation | associated | PD | 21435719 | |
| PA451743 | trastuzumab | Chemical | VariantAnnotation | not associated | PD | 27995989 | |
| PA451799 | troglitazone | Chemical | VipGene | associated | 12732844 | ||
| PA451846 | valproic acid | Chemical | VariantAnnotation | not associated | PD | ||
| PA451877 | vinblastine | Chemical | VariantAnnotation | not associated | PD | 23323945 | |
| PA452604 | xenobiotics | Chemical | VipGene | associated | 9285043, 9851677, 11317340 | ||
| PA452621 | antineoplastic agents | Chemical | VariantAnnotation | not associated | PD | 26644204 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38178055 | 2024 | Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children. | 0 |
| 38419025 | 2024 | Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study. | 0 |
| 38462864 | 2024 | Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms. | 0 |
| 38518393 | 2024 | Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study. | 0 |
| 38178055 | 2024 | Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children. | 0 |
| 38419025 | 2024 | Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study. | 0 |
| 38462864 | 2024 | Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms. | 0 |
| 38518393 | 2024 | Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study. | 0 |
| 36305131 | 2023 | Impact of GSTT1 and GSTM1 Polymorphisms in the Susceptibility to Philadelphia Negative Chronic Myeloid Leukaemia. | 0 |
| 36703205 | 2023 | Air pollution associated acute respiratory inflammation and modification by GSTM1 and GSTT1 gene polymorphisms: a panel study of healthy undergraduates. | 2 |
| 36833382 | 2023 | Association of GSTTI, M1 and Polymorphism in GSTPI with Chronic Periodontal Disease in a Pakistani Population. | 1 |
| 36963735 | 2023 | Association of NAT2, GSTT1, and GSTM1 gene polymorphisms withprostate cancer risk in Bangladeshi population. | 0 |
| 37054833 | 2023 | Mixed exposure effect of seminal metals on semen quality, mediation of total antioxidant capacity, and moderation of GSTM1/GSTT1 gene deletion in Chinese reproductive-aged men. | 1 |
| 37113088 | 2023 | Absence of GSTT1 and polymorphisms in GSTP1 and TP53 are associated with the incidence of acne vulgaris. | 2 |
| 37326751 | 2023 | Progonostic effect of GSTM1/GSTT1 polymorphism in determining cardiovascular diseases risk among type 2 diabetes patients in South Indian population. | 0 |
Citation
Dessen P
GSTT1 (glutathione S-transferase theta 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40774/gstt1
