HCK (HCK proto-oncogene, Src family tyrosine kinase)

2003-02-01  

Identity

HGNC
LOCATION
20q11.21
LOCUSID
ALIAS
JTK9,p59Hck,p61Hck
FUSION GENES

Other Information

Locus ID:

NCBI: 3055
MIM: 142370
HGNC: 4840
Ensembl: ENSG00000101336

Variants:

dbSNP: 3055
ClinVar: 3055
TCGA: ENSG00000101336
COSMIC: HCK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101336ENST00000262651H7BXG4
ENSG00000101336ENST00000375852J3KPD6
ENSG00000101336ENST00000375862H0Y3C5
ENSG00000101336ENST00000486475H7C5P9
ENSG00000101336ENST00000518730P08631
ENSG00000101336ENST00000520553P08631
ENSG00000101336ENST00000538448P08631
ENSG00000101336ENST00000629881P08631

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
The role of Nef in HIV-1 replication and disease pathogenesisREACTOMER-HSA-164952
Nef and signal transductionREACTOMER-HSA-164944
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
Regulation of signaling by CBLREACTOMER-HSA-912631

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
207980612010Multidomain assembled states of Hck tyrosine kinase in solution.80
119767262002SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo.41
18759271991Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization.38
162718952005The N-terminal end of the catalytic domain of SRC kinase Hck is a conformational switch implicated in long-range allosteric regulation.34
238964102013The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.30
162103162005Activation of the Src family kinase Hck without SH3-linker release.26
220216122011Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1.24
145511972003Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain.21
150104622004Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.21
271432572016HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib.21

Citation

Dessen P

HCK (HCK proto-oncogene, Src family tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40798/hck