Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HCK (HCK proto-oncogene, Src family tyrosine kinase)

Identity

Alias_nameshemopoietic cell kinase
Alias_symbol (synonym)JTK9
Other aliasp59Hck
p61Hck
HGNC (Hugo) HCK
LocusID (NCBI) 3055
Atlas_Id 40798
Location 20q11.21  [Link to chromosome band 20q11]
Location_base_pair Starts at 30639991 and ends at 30689657 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HCK (20q11.21) / CCM2L (20q11.21)HCK (20q11.21) / ENG (9q34.11)HCK (20q11.21) / NOL4L20q11.21 ()
RPL37A (2q35) / HCK (20q11.21)HCK 20q11.21 C20orf160

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(11)(q23q23) KMT2A/CBL::t(11;11)(q23;q23) KMT2A/CBL


External links

Nomenclature
HGNC (Hugo)HCK   4840
Cards
Entrez_Gene (NCBI)HCK  3055  HCK proto-oncogene, Src family tyrosine kinase
AliasesJTK9; p59Hck; p61Hck
GeneCards (Weizmann)HCK
Ensembl hg19 (Hinxton)ENSG00000101336 [Gene_View]  chr20:30639991-30689657 [Contig_View]  HCK [Vega]
Ensembl hg38 (Hinxton)ENSG00000101336 [Gene_View]  chr20:30639991-30689657 [Contig_View]  HCK [Vega]
ICGC DataPortalENSG00000101336
TCGA cBioPortalHCK
AceView (NCBI)HCK
Genatlas (Paris)HCK
WikiGenes3055
SOURCE (Princeton)HCK
Genetics Home Reference (NIH)HCK
Genomic and cartography
GoldenPath hg19 (UCSC)HCK  -     chr20:30639991-30689657 +  20q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HCK  -     20q11.21   [Description]    (hg38-Dec_2013)
EnsemblHCK - 20q11.21 [CytoView hg19]  HCK - 20q11.21 [CytoView hg38]
Mapping of homologs : NCBIHCK [Mapview hg19]  HCK [Mapview hg38]
OMIM142370   
Gene and transcription
Genbank (Entrez)AK026432 AK225819 AK289896 AK290928 AK298726
RefSeq transcript (Entrez)NM_001172129 NM_001172130 NM_001172131 NM_001172132 NM_001172133 NM_002110
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_029471 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)HCK
Cluster EST : UnigeneHs.655210 [ NCBI ]
CGAP (NCI)Hs.655210
Alternative Splicing GalleryENSG00000101336
Gene ExpressionHCK [ NCBI-GEO ]   HCK [ EBI - ARRAY_EXPRESS ]   HCK [ SEEK ]   HCK [ MEM ]
Gene Expression Viewer (FireBrowse)HCK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3055
GTEX Portal (Tissue expression)HCK
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08631   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08631  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08631
Splice isoforms : SwissVarP08631
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusP08631
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)HCK
DMDM Disease mutations3055
Blocks (Seattle)HCK
PDB (SRS)1AD5    1BU1    1QCF    2C0I    2C0O    2C0T    2HCK    2HK5    2OI3    2OJ2    3HCK    3NHN    3RBB    3REA    3REB    3VRY    3VRZ    3VS0    3VS1    3VS2    3VS3    3VS4    3VS5    3VS6    3VS7    4HCK    4LUD    4LUE    4ORZ    4U5W    5HCK   
PDB (PDBSum)1AD5    1BU1    1QCF    2C0I    2C0O    2C0T    2HCK    2HK5    2OI3    2OJ2    3HCK    3NHN    3RBB    3REA    3REB    3VRY    3VRZ    3VS0    3VS1    3VS2    3VS3    3VS4    3VS5    3VS6    3VS7    4HCK    4LUD    4LUE    4ORZ    4U5W    5HCK   
PDB (IMB)1AD5    1BU1    1QCF    2C0I    2C0O    2C0T    2HCK    2HK5    2OI3    2OJ2    3HCK    3NHN    3RBB    3REA    3REB    3VRY    3VRZ    3VS0    3VS1    3VS2    3VS3    3VS4    3VS5    3VS6    3VS7    4HCK    4LUD    4LUE    4ORZ    4U5W    5HCK   
PDB (RSDB)1AD5    1BU1    1QCF    2C0I    2C0O    2C0T    2HCK    2HK5    2OI3    2OJ2    3HCK    3NHN    3RBB    3REA    3REB    3VRY    3VRZ    3VS0    3VS1    3VS2    3VS3    3VS4    3VS5    3VS6    3VS7    4HCK    4LUD    4LUE    4ORZ    4U5W    5HCK   
Structural Biology KnowledgeBase1AD5    1BU1    1QCF    2C0I    2C0O    2C0T    2HCK    2HK5    2OI3    2OJ2    3HCK    3NHN    3RBB    3REA    3REB    3VRY    3VRZ    3VS0    3VS1    3VS2    3VS3    3VS4    3VS5    3VS6    3VS7    4HCK    4LUD    4LUE    4ORZ    4U5W    5HCK   
SCOP (Structural Classification of Proteins)1AD5    1BU1    1QCF    2C0I    2C0O    2C0T    2HCK    2HK5    2OI3    2OJ2    3HCK    3NHN    3RBB    3REA    3REB    3VRY    3VRZ    3VS0    3VS1    3VS2    3VS3    3VS4    3VS5    3VS6    3VS7    4HCK    4LUD    4LUE    4ORZ    4U5W    5HCK   
CATH (Classification of proteins structures)1AD5    1BU1    1QCF    2C0I    2C0O    2C0T    2HCK    2HK5    2OI3    2OJ2    3HCK    3NHN    3RBB    3REA    3REB    3VRY    3VRZ    3VS0    3VS1    3VS2    3VS3    3VS4    3VS5    3VS6    3VS7    4HCK    4LUD    4LUE    4ORZ    4U5W    5HCK   
SuperfamilyP08631
Human Protein AtlasENSG00000101336
Peptide AtlasP08631
HPRD00796
IPIIPI00646510   IPI00029769   IPI00430857   IPI00956008   IPI00956028   IPI00946888   IPI00946157   IPI00946853   
Protein Interaction databases
DIP (DOE-UCLA)P08631
IntAct (EBI)P08631
FunCoupENSG00000101336
BioGRIDHCK
STRING (EMBL)HCK
ZODIACHCK
Ontologies - Pathways
QuickGOP08631
Ontology : AmiGOleukocyte migration involved in immune response  innate immune response-activating signal transduction  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  nucleus  lysosome  Golgi apparatus  cytosol  actin filament  caveola  focal adhesion  protein phosphorylation  inflammatory response  cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  integrin-mediated signaling pathway  mesoderm development  positive regulation of cell proliferation  regulation of cell shape  viral process  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  transport vesicle  cell differentiation  positive regulation of actin filament polymerization  extrinsic component of cytoplasmic side of plasma membrane  lipopolysaccharide-mediated signaling pathway  peptidyl-tyrosine autophosphorylation  Fc-gamma receptor signaling pathway involved in phagocytosis  cell projection  negative regulation of apoptotic process  leukocyte degranulation  respiratory burst after phagocytosis  protein autophosphorylation  regulation of defense response to virus by virus  regulation of inflammatory response  regulation of phagocytosis  regulation of sequence-specific DNA binding transcription factor activity  interferon-gamma-mediated signaling pathway  regulation of podosome assembly  positive regulation of actin cytoskeleton reorganization  positive regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIleukocyte migration involved in immune response  innate immune response-activating signal transduction  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  nucleus  lysosome  Golgi apparatus  cytosol  actin filament  caveola  focal adhesion  protein phosphorylation  inflammatory response  cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  integrin-mediated signaling pathway  mesoderm development  positive regulation of cell proliferation  regulation of cell shape  viral process  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  transport vesicle  cell differentiation  positive regulation of actin filament polymerization  extrinsic component of cytoplasmic side of plasma membrane  lipopolysaccharide-mediated signaling pathway  peptidyl-tyrosine autophosphorylation  Fc-gamma receptor signaling pathway involved in phagocytosis  cell projection  negative regulation of apoptotic process  leukocyte degranulation  respiratory burst after phagocytosis  protein autophosphorylation  regulation of defense response to virus by virus  regulation of inflammatory response  regulation of phagocytosis  regulation of sequence-specific DNA binding transcription factor activity  interferon-gamma-mediated signaling pathway  regulation of podosome assembly  positive regulation of actin cytoskeleton reorganization  positive regulation of actin cytoskeleton reorganization  
Pathways : BIOCARTAHIV-1 defeats host-mediated resistance by CEM15 [Genes]    Roles of -arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]   
Pathways : KEGGChemokine signaling pathway    Fc gamma R-mediated phagocytosis   
NDEx NetworkHCK
Atlas of Cancer Signalling NetworkHCK
Wikipedia pathwaysHCK
Orthology - Evolution
OrthoDB3055
GeneTree (enSembl)ENSG00000101336
Phylogenetic Trees/Animal Genes : TreeFamHCK
HOVERGENP08631
HOGENOMP08631
Homologs : HomoloGeneHCK
Homology/Alignments : Family Browser (UCSC)HCK
Gene fusions - Rearrangements
Fusion : MitelmanHCK/CCM2L [20q11.21/20q11.21]  
Fusion: TCGAHCK 20q11.21 C20orf160 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCK
dbVarHCK
ClinVarHCK
1000_GenomesHCK 
Exome Variant ServerHCK
ExAC (Exome Aggregation Consortium)HCK (select the gene name)
Genetic variants : HAPMAP3055
Genomic Variants (DGV)HCK [DGVbeta]
DECIPHER (Syndromes)20:30639991-30689657  ENSG00000101336
CONAN: Copy Number AnalysisHCK 
Mutations
ICGC Data PortalHCK 
TCGA Data PortalHCK 
Broad Tumor PortalHCK
OASIS PortalHCK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHCK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HCK
DgiDB (Drug Gene Interaction Database)HCK
DoCM (Curated mutations)HCK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HCK (select a term)
intoGenHCK
Cancer3DHCK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142370   
Orphanet
MedgenHCK
Genetic Testing Registry HCK
NextProtP08631 [Medical]
TSGene3055
GENETestsHCK
Huge Navigator HCK [HugePedia]
snp3D : Map Gene to Disease3055
BioCentury BCIQHCK
ClinGenHCK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3055
Chemical/Pharm GKB GenePA29216
Clinical trialHCK
Miscellaneous
canSAR (ICR)HCK (select the gene name)
Probes
Litterature
PubMed215 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHCK
EVEXHCK
GoPubMedHCK
iHOPHCK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:03:28 CEST 2017

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