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HCRTR1 (hypocretin receptor 1)

Identity

Alias_nameshypocretin (orexin) receptor 1
Alias_symbol (synonym)OX1R
Other alias
HGNC (Hugo) HCRTR1
LocusID (NCBI) 3061
Atlas_Id 49911
Location 1p35.2  [Link to chromosome band 1p35]
Location_base_pair Starts at 32083301 and ends at 32092919 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAF1 (1p32.3) / HCRTR1 (1p35.2)HCRTR1 (1p35.2) / CYB5R1 (1q32.1)SH3BGRL3 (1p36.11) / HCRTR1 (1p35.2)
FAF1 1p32.3 / HCRTR1 1p35.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HCRTR1   4848
Cards
Entrez_Gene (NCBI)HCRTR1  3061  hypocretin receptor 1
AliasesOX1R
GeneCards (Weizmann)HCRTR1
Ensembl hg19 (Hinxton)ENSG00000121764 [Gene_View]  chr1:32083301-32092919 [Contig_View]  HCRTR1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000121764 [Gene_View]  chr1:32083301-32092919 [Contig_View]  HCRTR1 [Vega]
ICGC DataPortalENSG00000121764
TCGA cBioPortalHCRTR1
AceView (NCBI)HCRTR1
Genatlas (Paris)HCRTR1
WikiGenes3061
SOURCE (Princeton)HCRTR1
Genetics Home Reference (NIH)HCRTR1
Genomic and cartography
GoldenPath hg19 (UCSC)HCRTR1  -     chr1:32083301-32092919 +  1p35.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HCRTR1  -     1p35.2   [Description]    (hg38-Dec_2013)
EnsemblHCRTR1 - 1p35.2 [CytoView hg19]  HCRTR1 - 1p35.2 [CytoView hg38]
Mapping of homologs : NCBIHCRTR1 [Mapview hg19]  HCRTR1 [Mapview hg38]
OMIM602392   
Gene and transcription
Genbank (Entrez)AF041243 AK290521 BC035686 BC074796 CO960455
RefSeq transcript (Entrez)NM_001525
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)HCRTR1
Cluster EST : UnigeneHs.388226 [ NCBI ]
CGAP (NCI)Hs.388226
Alternative Splicing GalleryENSG00000121764
Gene ExpressionHCRTR1 [ NCBI-GEO ]   HCRTR1 [ EBI - ARRAY_EXPRESS ]   HCRTR1 [ SEEK ]   HCRTR1 [ MEM ]
Gene Expression Viewer (FireBrowse)HCRTR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3061
GTEX Portal (Tissue expression)HCRTR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43613   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43613  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43613
Splice isoforms : SwissVarO43613
PhosPhoSitePlusO43613
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Orexin_rcpt    Orexin_rcpt_1   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)HCRTR1
DMDM Disease mutations3061
Blocks (Seattle)HCRTR1
SuperfamilyO43613
Human Protein AtlasENSG00000121764
Peptide AtlasO43613
HPRD03863
IPIIPI00013375   IPI00647195   
Protein Interaction databases
DIP (DOE-UCLA)O43613
IntAct (EBI)O43613
FunCoupENSG00000121764
BioGRIDHCRTR1
STRING (EMBL)HCRTR1
ZODIACHCRTR1
Ontologies - Pathways
QuickGOO43613
Ontology : AmiGOG-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  neuropeptide signaling pathway  synaptic transmission  feeding behavior  neuropeptide receptor activity  orexin receptor activity  peptide hormone binding  cellular response to hormone stimulus  peptide binding  regulation of circadian sleep/wake cycle, sleep  response to peptide  
Ontology : EGO-EBIG-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  neuropeptide signaling pathway  synaptic transmission  feeding behavior  neuropeptide receptor activity  orexin receptor activity  peptide hormone binding  cellular response to hormone stimulus  peptide binding  regulation of circadian sleep/wake cycle, sleep  response to peptide  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkHCRTR1
Atlas of Cancer Signalling NetworkHCRTR1
Wikipedia pathwaysHCRTR1
Orthology - Evolution
OrthoDB3061
GeneTree (enSembl)ENSG00000121764
Phylogenetic Trees/Animal Genes : TreeFamHCRTR1
HOVERGENO43613
HOGENOMO43613
Homologs : HomoloGeneHCRTR1
Homology/Alignments : Family Browser (UCSC)HCRTR1
Gene fusions - Rearrangements
Fusion : MitelmanFAF1/HCRTR1 [1p32.3/1p35.2]  [t(1;1)(p32;p35)]  
Fusion: TCGAFAF1 1p32.3 HCRTR1 1p35.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHCRTR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HCRTR1
dbVarHCRTR1
ClinVarHCRTR1
1000_GenomesHCRTR1 
Exome Variant ServerHCRTR1
ExAC (Exome Aggregation Consortium)HCRTR1 (select the gene name)
Genetic variants : HAPMAP3061
Genomic Variants (DGV)HCRTR1 [DGVbeta]
DECIPHER (Syndromes)1:32083301-32092919  ENSG00000121764
CONAN: Copy Number AnalysisHCRTR1 
Mutations
ICGC Data PortalHCRTR1 
TCGA Data PortalHCRTR1 
Broad Tumor PortalHCRTR1
OASIS PortalHCRTR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHCRTR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHCRTR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HCRTR1
DgiDB (Drug Gene Interaction Database)HCRTR1
DoCM (Curated mutations)HCRTR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HCRTR1 (select a term)
intoGenHCRTR1
Cancer3DHCRTR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602392   
Orphanet
MedgenHCRTR1
Genetic Testing Registry HCRTR1
NextProtO43613 [Medical]
TSGene3061
GENETestsHCRTR1
Huge Navigator HCRTR1 [HugePedia]
snp3D : Map Gene to Disease3061
BioCentury BCIQHCRTR1
ClinGenHCRTR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3061
Chemical/Pharm GKB GenePA29222
Clinical trialHCRTR1
Miscellaneous
canSAR (ICR)HCRTR1 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHCRTR1
EVEXHCRTR1
GoPubMedHCRTR1
iHOPHCRTR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:08:42 CET 2017

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