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HDAC6 (histone deacetylase 6)

Identity

Alias_namesregulatory subunit 90
Alias_symbol (synonym)KIAA0901
JM21
HD6
FLJ16239
PPP1R90
Other aliasCPBHM
HGNC (Hugo) HDAC6
LocusID (NCBI) 10013
Atlas_Id 40807
Location Xp11.23  [Link to chromosome band Xp11]
Location_base_pair Starts at 48801377 and ends at 48824982 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HDAC6 (Xp11.23) / STIM2 (4p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HDAC6   14064
Cards
Entrez_Gene (NCBI)HDAC6  10013  histone deacetylase 6
AliasesCPBHM; HD6; JM21; PPP1R90
GeneCards (Weizmann)HDAC6
Ensembl hg19 (Hinxton)ENSG00000094631 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000094631 [Gene_View]  chrX:48801377-48824982 [Contig_View]  HDAC6 [Vega]
ICGC DataPortalENSG00000094631
TCGA cBioPortalHDAC6
AceView (NCBI)HDAC6
Genatlas (Paris)HDAC6
WikiGenes10013
SOURCE (Princeton)HDAC6
Genetics Home Reference (NIH)HDAC6
Genomic and cartography
GoldenPath hg38 (UCSC)HDAC6  -     chrX:48801377-48824982 +  Xp11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HDAC6  -     Xp11.23   [Description]    (hg19-Feb_2009)
EnsemblHDAC6 - Xp11.23 [CytoView hg19]  HDAC6 - Xp11.23 [CytoView hg38]
Mapping of homologs : NCBIHDAC6 [Mapview hg19]  HDAC6 [Mapview hg38]
OMIM300272   300863   
Gene and transcription
Genbank (Entrez)AB020708 AF132609 AF174499 AJ011972 AK001543
RefSeq transcript (Entrez)NM_001321225 NM_001321226 NM_001321227 NM_001321228 NM_001321229 NM_001321230 NM_001321231 NM_006044
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HDAC6
Cluster EST : UnigeneHs.6764 [ NCBI ]
CGAP (NCI)Hs.6764
Alternative Splicing GalleryENSG00000094631
Gene ExpressionHDAC6 [ NCBI-GEO ]   HDAC6 [ EBI - ARRAY_EXPRESS ]   HDAC6 [ SEEK ]   HDAC6 [ MEM ]
Gene Expression Viewer (FireBrowse)HDAC6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10013
GTEX Portal (Tissue expression)HDAC6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBN7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBN7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBN7
Splice isoforms : SwissVarQ9UBN7
PhosPhoSitePlusQ9UBN7
Domaine pattern : Prosite (Expaxy)ZF_UBP (PS50271)   
Domains : Interpro (EBI)His_deacetylse    His_deacetylse_dom    Znf_RING/FYVE/PHD    Znf_UBP   
Domain families : Pfam (Sanger)Hist_deacetyl (PF00850)    zf-UBP (PF02148)   
Domain families : Pfam (NCBI)pfam00850    pfam02148   
Domain families : Smart (EMBL)ZnF_UBP (SM00290)  
Conserved Domain (NCBI)HDAC6
DMDM Disease mutations10013
Blocks (Seattle)HDAC6
PDB (SRS)3C5K    3GV4    3PHD    5B8D    5EDU    5KH3    5KH7    5KH9   
PDB (PDBSum)3C5K    3GV4    3PHD    5B8D    5EDU    5KH3    5KH7    5KH9   
PDB (IMB)3C5K    3GV4    3PHD    5B8D    5EDU    5KH3    5KH7    5KH9   
PDB (RSDB)3C5K    3GV4    3PHD    5B8D    5EDU    5KH3    5KH7    5KH9   
Structural Biology KnowledgeBase3C5K    3GV4    3PHD    5B8D    5EDU    5KH3    5KH7    5KH9   
SCOP (Structural Classification of Proteins)3C5K    3GV4    3PHD    5B8D    5EDU    5KH3    5KH7    5KH9   
CATH (Classification of proteins structures)3C5K    3GV4    3PHD    5B8D    5EDU    5KH3    5KH7    5KH9   
SuperfamilyQ9UBN7
Human Protein AtlasENSG00000094631
Peptide AtlasQ9UBN7
HPRD02228
IPIIPI00940882   IPI00465375   IPI00939619   IPI00909242   IPI00005711   IPI00941641   IPI00644549   IPI00878591   IPI00878963   IPI00880136   IPI00877650   IPI00877840   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBN7
IntAct (EBI)Q9UBN7
FunCoupENSG00000094631
BioGRIDHDAC6
STRING (EMBL)HDAC6
ZODIACHDAC6
Ontologies - Pathways
QuickGOQ9UBN7
Ontology : AmiGOhistone deacetylase complex  protein polyubiquitination  core promoter binding  actin binding  histone deacetylase activity  histone deacetylase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  multivesicular body  cytosol  cytosol  microtubule  microtubule associated complex  cytoplasmic microtubule  caveola  transcription, DNA-templated  protein deacetylation  misfolded or incompletely synthesized protein catabolic process  intracellular protein transport  autophagy  negative regulation of microtubule depolymerization  beta-catenin binding  microtubule binding  microtubule binding  zinc ion binding  response to toxic substance  positive regulation of signal transduction  response to organic substance  regulation of receptor activity  regulation of autophagy  positive regulation of epithelial cell migration  negative regulation of hydrogen peroxide metabolic process  positive regulation of receptor biosynthetic process  inclusion body  aggresome  regulation of macroautophagy  histone deacetylation  histone deacetylation  enzyme binding  dynein complex  axon  dendrite  cell leading edge  polyubiquitin binding  ubiquitin protein ligase binding  regulation of protein stability  NAD-dependent histone deacetylase activity (H3-K14 specific)  lysosome localization  peptidyl-lysine deacetylation  cellular response to topologically incorrect protein  regulation of gene expression, epigenetic  histone deacetylase binding  tubulin deacetylase activity  tubulin deacetylase activity  tubulin deacetylase activity  alpha-tubulin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  perikaryon  protein complex disassembly  negative regulation of protein complex disassembly  regulation of fat cell differentiation  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  tau protein binding  perinuclear region of cytoplasm  beta-tubulin binding  collateral sprouting  negative regulation of oxidoreductase activity  mitochondrion localization  misfolded protein binding  response to misfolded protein  Hsp90 protein binding  cilium assembly  regulation of microtubule-based movement  regulation of androgen receptor signaling pathway  dendritic spine morphogenesis  parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  regulation of establishment of protein localization  cellular response to hydrogen peroxide  dynein complex binding  aggresome assembly  polyubiquitinated misfolded protein transport  Hsp90 deacetylation  response to growth factor  histone H3 deacetylation  cellular response to misfolded protein  positive regulation of chaperone-mediated protein complex assembly  tubulin deacetylation  tubulin deacetylation  positive regulation of hydrogen peroxide-mediated programmed cell death  regulation of mitophagy  
Ontology : EGO-EBIhistone deacetylase complex  protein polyubiquitination  core promoter binding  actin binding  histone deacetylase activity  histone deacetylase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  multivesicular body  cytosol  cytosol  microtubule  microtubule associated complex  cytoplasmic microtubule  caveola  transcription, DNA-templated  protein deacetylation  misfolded or incompletely synthesized protein catabolic process  intracellular protein transport  autophagy  negative regulation of microtubule depolymerization  beta-catenin binding  microtubule binding  microtubule binding  zinc ion binding  response to toxic substance  positive regulation of signal transduction  response to organic substance  regulation of receptor activity  regulation of autophagy  positive regulation of epithelial cell migration  negative regulation of hydrogen peroxide metabolic process  positive regulation of receptor biosynthetic process  inclusion body  aggresome  regulation of macroautophagy  histone deacetylation  histone deacetylation  enzyme binding  dynein complex  axon  dendrite  cell leading edge  polyubiquitin binding  ubiquitin protein ligase binding  regulation of protein stability  NAD-dependent histone deacetylase activity (H3-K14 specific)  lysosome localization  peptidyl-lysine deacetylation  cellular response to topologically incorrect protein  regulation of gene expression, epigenetic  histone deacetylase binding  tubulin deacetylase activity  tubulin deacetylase activity  tubulin deacetylase activity  alpha-tubulin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  perikaryon  protein complex disassembly  negative regulation of protein complex disassembly  regulation of fat cell differentiation  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  tau protein binding  perinuclear region of cytoplasm  beta-tubulin binding  collateral sprouting  negative regulation of oxidoreductase activity  mitochondrion localization  misfolded protein binding  response to misfolded protein  Hsp90 protein binding  cilium assembly  regulation of microtubule-based movement  regulation of androgen receptor signaling pathway  dendritic spine morphogenesis  parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  regulation of establishment of protein localization  cellular response to hydrogen peroxide  dynein complex binding  aggresome assembly  polyubiquitinated misfolded protein transport  Hsp90 deacetylation  response to growth factor  histone H3 deacetylation  cellular response to misfolded protein  positive regulation of chaperone-mediated protein complex assembly  tubulin deacetylation  tubulin deacetylation  positive regulation of hydrogen peroxide-mediated programmed cell death  regulation of mitophagy  
Pathways : BIOCARTASumoylation by RanBP2 Regulates Transcriptional Repression [Genes]    CARM1 and Regulation of the Estrogen Receptor [Genes]   
Pathways : KEGGAlcoholism    Viral carcinogenesis   
NDEx NetworkHDAC6
Atlas of Cancer Signalling NetworkHDAC6
Wikipedia pathwaysHDAC6
Orthology - Evolution
OrthoDB10013
GeneTree (enSembl)ENSG00000094631
Phylogenetic Trees/Animal Genes : TreeFamHDAC6
HOVERGENQ9UBN7
HOGENOMQ9UBN7
Homologs : HomoloGeneHDAC6
Homology/Alignments : Family Browser (UCSC)HDAC6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHDAC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HDAC6
dbVarHDAC6
ClinVarHDAC6
1000_GenomesHDAC6 
Exome Variant ServerHDAC6
ExAC (Exome Aggregation Consortium)HDAC6 (select the gene name)
Genetic variants : HAPMAP10013
Genomic Variants (DGV)HDAC6 [DGVbeta]
DECIPHERHDAC6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHDAC6 
Mutations
ICGC Data PortalHDAC6 
TCGA Data PortalHDAC6 
Broad Tumor PortalHDAC6
OASIS PortalHDAC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHDAC6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHDAC6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch HDAC6
DgiDB (Drug Gene Interaction Database)HDAC6
DoCM (Curated mutations)HDAC6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HDAC6 (select a term)
intoGenHDAC6
Cancer3DHDAC6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300272    300863   
Orphanet17556   
MedgenHDAC6
Genetic Testing Registry HDAC6
NextProtQ9UBN7 [Medical]
TSGene10013
GENETestsHDAC6
Huge Navigator HDAC6 [HugePedia]
snp3D : Map Gene to Disease10013
BioCentury BCIQHDAC6
ClinGenHDAC6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10013
Chemical/Pharm GKB GenePA29231
Clinical trialHDAC6
Miscellaneous
canSAR (ICR)HDAC6 (select the gene name)
Probes
Litterature
PubMed281 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHDAC6
EVEXHDAC6
GoPubMedHDAC6
iHOPHDAC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:18:31 CEST 2017

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