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HGFAC (HGF activator)

Identity

Alias_symbol (synonym)HGFAP
HGFA
Other alias
HGNC (Hugo) HGFAC
LocusID (NCBI) 3083
Atlas_Id 46296
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 3441933 and ends at 3449495 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HGFAC   4894
Cards
Entrez_Gene (NCBI)HGFAC  3083  HGF activator
AliasesHGFA
GeneCards (Weizmann)HGFAC
Ensembl hg19 (Hinxton)ENSG00000109758 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109758 [Gene_View]  chr4:3441933-3449495 [Contig_View]  HGFAC [Vega]
ICGC DataPortalENSG00000109758
TCGA cBioPortalHGFAC
AceView (NCBI)HGFAC
Genatlas (Paris)HGFAC
WikiGenes3083
SOURCE (Princeton)HGFAC
Genetics Home Reference (NIH)HGFAC
Genomic and cartography
GoldenPath hg38 (UCSC)HGFAC  -     chr4:3441933-3449495 +  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HGFAC  -     4p16.3   [Description]    (hg19-Feb_2009)
EnsemblHGFAC - 4p16.3 [CytoView hg19]  HGFAC - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBIHGFAC [Mapview hg19]  HGFAC [Mapview hg38]
OMIM604552   
Gene and transcription
Genbank (Entrez)AK314099 BC112190 BC112192 D14012
RefSeq transcript (Entrez)NM_001297439 NM_001528
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HGFAC
Cluster EST : UnigeneHs.104 [ NCBI ]
CGAP (NCI)Hs.104
Alternative Splicing GalleryENSG00000109758
Gene ExpressionHGFAC [ NCBI-GEO ]   HGFAC [ EBI - ARRAY_EXPRESS ]   HGFAC [ SEEK ]   HGFAC [ MEM ]
Gene Expression Viewer (FireBrowse)HGFAC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3083
GTEX Portal (Tissue expression)HGFAC
Human Protein AtlasENSG00000109758-HGFAC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04756   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04756  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04756
Splice isoforms : SwissVarQ04756
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusQ04756
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    FN1_1 (PS01253)    FN1_2 (PS51091)    FN2_1 (PS00023)    FN2_2 (PS51092)    KRINGLE_1 (PS00021)    KRINGLE_2 (PS50070)    TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Coagulation_fac_XIIa/HGFA    EGF-like_CS    EGF-like_dom    Fibronectin_type1    FN_type2_col-bd    Kringle    Kringle-like    Kringle_CS    Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)EGF (PF00008)    fn1 (PF00039)    fn2 (PF00040)    Kringle (PF00051)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00008    pfam00039    pfam00040    pfam00051    pfam00089   
Domain families : Smart (EMBL)EGF (SM00181)  FN1 (SM00058)  FN2 (SM00059)  KR (SM00130)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)HGFAC
DMDM Disease mutations3083
Blocks (Seattle)HGFAC
PDB (SRS)1YBW    1YC0    2R0K    2R0L    2WUB    2WUC    3K2U   
PDB (PDBSum)1YBW    1YC0    2R0K    2R0L    2WUB    2WUC    3K2U   
PDB (IMB)1YBW    1YC0    2R0K    2R0L    2WUB    2WUC    3K2U   
PDB (RSDB)1YBW    1YC0    2R0K    2R0L    2WUB    2WUC    3K2U   
Structural Biology KnowledgeBase1YBW    1YC0    2R0K    2R0L    2WUB    2WUC    3K2U   
SCOP (Structural Classification of Proteins)1YBW    1YC0    2R0K    2R0L    2WUB    2WUC    3K2U   
CATH (Classification of proteins structures)1YBW    1YC0    2R0K    2R0L    2WUB    2WUC    3K2U   
SuperfamilyQ04756
Human Protein Atlas [tissue]ENSG00000109758-HGFAC [tissue]
Peptide AtlasQ04756
HPRD05184
IPIIPI00029193   IPI00967086   
Protein Interaction databases
DIP (DOE-UCLA)Q04756
IntAct (EBI)Q04756
FunCoupENSG00000109758
BioGRIDHGFAC
STRING (EMBL)HGFAC
ZODIACHGFAC
Ontologies - Pathways
QuickGOQ04756
Ontology : AmiGOserine-type endopeptidase activity  extracellular region  extracellular space  cytosol  proteolysis  serine-type peptidase activity  
Ontology : EGO-EBIserine-type endopeptidase activity  extracellular region  extracellular space  cytosol  proteolysis  serine-type peptidase activity  
NDEx NetworkHGFAC
Atlas of Cancer Signalling NetworkHGFAC
Wikipedia pathwaysHGFAC
Orthology - Evolution
OrthoDB3083
GeneTree (enSembl)ENSG00000109758
Phylogenetic Trees/Animal Genes : TreeFamHGFAC
HOVERGENQ04756
HOGENOMQ04756
Homologs : HomoloGeneHGFAC
Homology/Alignments : Family Browser (UCSC)HGFAC
Gene fusions - Rearrangements
Tumor Fusion PortalHGFAC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHGFAC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HGFAC
dbVarHGFAC
ClinVarHGFAC
1000_GenomesHGFAC 
Exome Variant ServerHGFAC
ExAC (Exome Aggregation Consortium)ENSG00000109758
GNOMAD BrowserENSG00000109758
Genetic variants : HAPMAP3083
Genomic Variants (DGV)HGFAC [DGVbeta]
DECIPHERHGFAC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHGFAC 
Mutations
ICGC Data PortalHGFAC 
TCGA Data PortalHGFAC 
Broad Tumor PortalHGFAC
OASIS PortalHGFAC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHGFAC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHGFAC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HGFAC
DgiDB (Drug Gene Interaction Database)HGFAC
DoCM (Curated mutations)HGFAC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HGFAC (select a term)
intoGenHGFAC
Cancer3DHGFAC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604552   
Orphanet
DisGeNETHGFAC
MedgenHGFAC
Genetic Testing Registry HGFAC
NextProtQ04756 [Medical]
TSGene3083
GENETestsHGFAC
Target ValidationHGFAC
Huge Navigator HGFAC [HugePedia]
snp3D : Map Gene to Disease3083
BioCentury BCIQHGFAC
ClinGenHGFAC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3083
Chemical/Pharm GKB GenePA29270
Clinical trialHGFAC
Miscellaneous
canSAR (ICR)HGFAC (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHGFAC
EVEXHGFAC
GoPubMedHGFAC
iHOPHGFAC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:16:04 CET 2017

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