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HK2 (hexokinase 2)

Identity

HGNC (Hugo) HK2
LocusID (NCBI) 3099
Atlas_Id 40827
Location 2p12  [Link to chromosome band 2p12]
Location_base_pair Starts at 75059782 and ends at 75120481 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAM50A (Xq28) / HK2 (2p12)HK2 (2p12) / ONECUT3 (19p13.3)HK2 (2p12) / TET3 (2p13.1)
POLE4 (2p12) / HK2 (2p12)HK2 2p12 / ONECUT3 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HK2   4923
Cards
Entrez_Gene (NCBI)HK2  3099  hexokinase 2
AliasesHKII; HXK2
GeneCards (Weizmann)HK2
Ensembl hg19 (Hinxton)ENSG00000159399 [Gene_View]  chr2:75059782-75120481 [Contig_View]  HK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000159399 [Gene_View]  chr2:75059782-75120481 [Contig_View]  HK2 [Vega]
ICGC DataPortalENSG00000159399
TCGA cBioPortalHK2
AceView (NCBI)HK2
Genatlas (Paris)HK2
WikiGenes3099
SOURCE (Princeton)HK2
Genetics Home Reference (NIH)HK2
Genomic and cartography
GoldenPath hg19 (UCSC)HK2  -     chr2:75059782-75120481 +  2p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HK2  -     2p12   [Description]    (hg38-Dec_2013)
EnsemblHK2 - 2p12 [CytoView hg19]  HK2 - 2p12 [CytoView hg38]
Mapping of homologs : NCBIHK2 [Mapview hg19]  HK2 [Mapview hg38]
OMIM601125   
Gene and transcription
Genbank (Entrez)AF086198 AF148513 AI085541 AI278414 AK290357
RefSeq transcript (Entrez)NM_000189
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)HK2
Cluster EST : UnigeneHs.591588 [ NCBI ]
CGAP (NCI)Hs.591588
Alternative Splicing GalleryENSG00000159399
Gene ExpressionHK2 [ NCBI-GEO ]   HK2 [ EBI - ARRAY_EXPRESS ]   HK2 [ SEEK ]   HK2 [ MEM ]
Gene Expression Viewer (FireBrowse)HK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3099
GTEX Portal (Tissue expression)HK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52789   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52789  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52789
Splice isoforms : SwissVarP52789
Catalytic activity : Enzyme2.7.1.1 [ Enzyme-Expasy ]   2.7.1.12.7.1.1 [ IntEnz-EBI ]   2.7.1.1 [ BRENDA ]   2.7.1.1 [ KEGG ]   
PhosPhoSitePlusP52789
Domaine pattern : Prosite (Expaxy)HEXOKINASE_1 (PS00378)    HEXOKINASE_2 (PS51748)   
Domains : Interpro (EBI)Hexokinase    Hexokinase_BS    Hexokinase_C    Hexokinase_N   
Domain families : Pfam (Sanger)Hexokinase_1 (PF00349)    Hexokinase_2 (PF03727)   
Domain families : Pfam (NCBI)pfam00349    pfam03727   
Conserved Domain (NCBI)HK2
DMDM Disease mutations3099
Blocks (Seattle)HK2
PDB (SRS)2NZT   
PDB (PDBSum)2NZT   
PDB (IMB)2NZT   
PDB (RSDB)2NZT   
Structural Biology KnowledgeBase2NZT   
SCOP (Structural Classification of Proteins)2NZT   
CATH (Classification of proteins structures)2NZT   
SuperfamilyP52789
Human Protein AtlasENSG00000159399
Peptide AtlasP52789
HPRD03080
IPIIPI00102864   IPI00917193   
Protein Interaction databases
DIP (DOE-UCLA)P52789
IntAct (EBI)P52789
FunCoupENSG00000159399
BioGRIDHK2
STRING (EMBL)HK2
ZODIACHK2
Ontologies - Pathways
QuickGOP52789
Ontology : AmiGOcellular glucose homeostasis  response to ischemia  glucokinase activity  glucokinase activity  hexokinase activity  protein binding  ATP binding  glucose binding  mitochondrial outer membrane  cytosol  cytosol  glycolytic process  lactation  apoptotic mitochondrial changes  fructokinase activity  glucose transport  membrane  mannokinase activity  negative regulation of mitochondrial membrane permeability  regulation of glucose import  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  glucose 6-phosphate metabolic process  canonical glycolysis  establishment of protein localization to mitochondrion  maintenance of protein location in mitochondrion  mitophagy in response to mitochondrial depolarization  negative regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIcellular glucose homeostasis  response to ischemia  glucokinase activity  glucokinase activity  hexokinase activity  protein binding  ATP binding  glucose binding  mitochondrial outer membrane  cytosol  cytosol  glycolytic process  lactation  apoptotic mitochondrial changes  fructokinase activity  glucose transport  membrane  mannokinase activity  negative regulation of mitochondrial membrane permeability  regulation of glucose import  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  glucose 6-phosphate metabolic process  canonical glycolysis  establishment of protein localization to mitochondrion  maintenance of protein location in mitochondrion  mitophagy in response to mitochondrial depolarization  negative regulation of reactive oxygen species metabolic process  
Pathways : KEGGGlycolysis / Gluconeogenesis    Fructose and mannose metabolism    Galactose metabolism    Starch and sucrose metabolism    Amino sugar and nucleotide sugar metabolism    Butirosin and neomycin biosynthesis    HIF-1 signaling pathway    Insulin signaling pathway    Type II diabetes mellitus    Carbohydrate digestion and absorption   
NDEx NetworkHK2
Atlas of Cancer Signalling NetworkHK2
Wikipedia pathwaysHK2
Orthology - Evolution
OrthoDB3099
GeneTree (enSembl)ENSG00000159399
Phylogenetic Trees/Animal Genes : TreeFamHK2
HOVERGENP52789
HOGENOMP52789
Homologs : HomoloGeneHK2
Homology/Alignments : Family Browser (UCSC)HK2
Gene fusions - Rearrangements
Fusion : MitelmanHK2/ONECUT3 [2p12/19p13.3]  
Fusion: TCGAHK2 2p12 ONECUT3 19p13.3 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HK2
dbVarHK2
ClinVarHK2
1000_GenomesHK2 
Exome Variant ServerHK2
ExAC (Exome Aggregation Consortium)HK2 (select the gene name)
Genetic variants : HAPMAP3099
Genomic Variants (DGV)HK2 [DGVbeta]
DECIPHER (Syndromes)2:75059782-75120481  ENSG00000159399
CONAN: Copy Number AnalysisHK2 
Mutations
ICGC Data PortalHK2 
TCGA Data PortalHK2 
Broad Tumor PortalHK2
OASIS PortalHK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch HK2
DgiDB (Drug Gene Interaction Database)HK2
DoCM (Curated mutations)HK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HK2 (select a term)
intoGenHK2
Cancer3DHK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601125   
Orphanet
MedgenHK2
Genetic Testing Registry HK2
NextProtP52789 [Medical]
TSGene3099
GENETestsHK2
Huge Navigator HK2 [HugePedia]
snp3D : Map Gene to Disease3099
BioCentury BCIQHK2
ClinGenHK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3099
Chemical/Pharm GKB GenePA29301
Clinical trialHK2
Miscellaneous
canSAR (ICR)HK2 (select the gene name)
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHK2
EVEXHK2
GoPubMedHK2
iHOPHK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:39:26 CET 2016

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