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HK2 (hexokinase 2)

Identity

Other namesHKII
HXK2
HGNC (Hugo) HK2
LocusID (NCBI) 3099
Location 2p12
Location_base_pair Starts at 75059782 and ends at 75120481 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HK2   4923
Cards
Entrez_Gene (NCBI)HK2  3099  hexokinase 2
GeneCards (Weizmann)HK2
Ensembl hg19 (Hinxton)ENSG00000159399 [Gene_View]  chr2:75059782-75120481 [Contig_View]  HK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000159399 [Gene_View]  chr2:75059782-75120481 [Contig_View]  HK2 [Vega]
ICGC DataPortalENSG00000159399
cBioPortalHK2
AceView (NCBI)HK2
Genatlas (Paris)HK2
WikiGenes3099
SOURCE (Princeton)HK2
Genomic and cartography
GoldenPath hg19 (UCSC)HK2  -     chr2:75059782-75120481 +  2p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HK2  -     2p12   [Description]    (hg38-Dec_2013)
EnsemblHK2 - 2p12 [CytoView hg19]  HK2 - 2p12 [CytoView hg38]
Mapping of homologs : NCBIHK2 [Mapview hg19]  HK2 [Mapview hg38]
OMIM601125   
Gene and transcription
Genbank (Entrez)AF086198 AF148513 AI085541 AI278414 AK290357
RefSeq transcript (Entrez)NM_000189
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_022184 NW_001838769 NW_004929300
Consensus coding sequences : CCDS (NCBI)HK2
Cluster EST : UnigeneHs.591588 [ NCBI ]
CGAP (NCI)Hs.591588
Alternative Splicing : Fast-db (Paris)GSHG0016590
Alternative Splicing GalleryENSG00000159399
Gene ExpressionHK2 [ NCBI-GEO ]     HK2 [ SEEK ]   HK2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52789 (Uniprot)
NextProtP52789  [Medical]
With graphics : InterProP52789
Splice isoforms : SwissVarP52789 (Swissvar)
Catalytic activity : Enzyme2.7.1.1 [ Enzyme-Expasy ]   2.7.1.12.7.1.1 [ IntEnz-EBI ]   2.7.1.1 [ BRENDA ]   2.7.1.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)HEXOKINASES (PS00378)   
Domains : Interpro (EBI)Hexokinase    Hexokinase_C    Hexokinase_CS    Hexokinase_N   
Related proteins : CluSTrP52789
Domain families : Pfam (Sanger)Hexokinase_1 (PF00349)    Hexokinase_2 (PF03727)   
Domain families : Pfam (NCBI)pfam00349    pfam03727   
DMDM Disease mutations3099
Blocks (Seattle)P52789
PDB (SRS)2NZT   
PDB (PDBSum)2NZT   
PDB (IMB)2NZT   
PDB (RSDB)2NZT   
Human Protein AtlasENSG00000159399
Peptide AtlasP52789
HPRD03080
IPIIPI00102864   IPI00917193   
Protein Interaction databases
DIP (DOE-UCLA)P52789
IntAct (EBI)P52789
FunCoupENSG00000159399
BioGRIDHK2
IntegromeDBHK2
STRING (EMBL)HK2
Ontologies - Pathways
QuickGOP52789
Ontology : AmiGOcellular glucose homeostasis  glucokinase activity  hexokinase activity  ATP binding  glucose binding  mitochondrial outer membrane  cytosol  carbohydrate metabolic process  glucose metabolic process  glycolytic process  lactation  apoptotic mitochondrial changes  hexose transport  fructokinase activity  glucose transport  membrane  mannokinase activity  small molecule metabolic process  regulation of glucose import  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  transmembrane transport  
Ontology : EGO-EBIcellular glucose homeostasis  glucokinase activity  hexokinase activity  ATP binding  glucose binding  mitochondrial outer membrane  cytosol  carbohydrate metabolic process  glucose metabolic process  glycolytic process  lactation  apoptotic mitochondrial changes  hexose transport  fructokinase activity  glucose transport  membrane  mannokinase activity  small molecule metabolic process  regulation of glucose import  carbohydrate phosphorylation  glucose 6-phosphate metabolic process  transmembrane transport  
Pathways : KEGGGlycolysis / Gluconeogenesis    Fructose and mannose metabolism    Galactose metabolism    Starch and sucrose metabolism    Amino sugar and nucleotide sugar metabolism    Butirosin and neomycin biosynthesis    HIF-1 signaling pathway    Insulin signaling pathway    Type II diabetes mellitus    Carbohydrate digestion and absorption   
Protein Interaction DatabaseHK2
DoCM (Curated mutations)HK2
Wikipedia pathwaysHK2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerHK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HK2
dbVarHK2
ClinVarHK2
1000_GenomesHK2 
Exome Variant ServerHK2
SNP (GeneSNP Utah)HK2
SNP : HGBaseHK2
Genetic variants : HAPMAPHK2
Genomic VariantsHK2  HK2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000159399 
Somatic Mutations in Cancer : COSMICHK2 
CONAN: Copy Number AnalysisHK2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:75059782-75120481
Mutations and Diseases : HGMDHK2
OMIM601125   
MedgenHK2
NextProtP52789 [Medical]
GENETestsHK2
Disease Genetic AssociationHK2
Huge Navigator HK2 [HugePedia]  HK2 [HugeCancerGEM]
snp3D : Map Gene to Disease3099
DGIdb (Drug Gene Interaction db)HK2
General knowledge
Homologs : HomoloGeneHK2
Homology/Alignments : Family Browser (UCSC)HK2
Phylogenetic Trees/Animal Genes : TreeFamHK2
Chemical/Protein Interactions : CTD3099
Chemical/Pharm GKB GenePA29301
Clinical trialHK2
Cancer Resource (Charite)ENSG00000159399
Other databases
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
CoreMineHK2
GoPubMedHK2
iHOPHK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:00:52 CET 2014

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