Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HK2 (hexokinase 2)

Identity

Other namesHKII
HXK2
HGNC (Hugo) HK2
LocusID (NCBI) 3099
Location 2p12
Location_base_pair Starts at 75059782 and ends at 75120481 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HK2   4923
Entrez_Gene (NCBI)HK2  3099  hexokinase 2
Cards
GeneCards (Weizmann)HK2
Ensembl (Hinxton)ENSG00000159399 [Gene_View]  chr2:75059782-75120481 [Contig_View]  HK2 [Vega]
AceView (NCBI)HK2
Genatlas (Paris)HK2
SOURCE (Stanford)NM_000189
Genomic and cartography
GoldenPath (UCSC)HK2  -  2p12   chr2:75059782-75120481 +  2p12   [Description]    (hg19-Feb_2009)
EnsemblHK2 - 2p12 [CytoView]
Mapping of homologs : NCBIHK2 [Mapview]
OMIM601125   
Gene and transcription
Genbank (Entrez)AF086198 AF148513 AI085541 AI278414 AK290357
RefSeq transcript (SRS)NM_000189
RefSeq transcript (Entrez)NM_000189
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NT_022184 NW_001838769 NW_004078005
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_022184 NW_001838769 NW_004078005
Consensus coding sequences : CCDS (NCBI)HK2
Cluster EST : UnigeneHs.591588 [ SRS ] Hs.591588 [ NCBI ]
CGAP (NCI)Hs.591588
Alternative Splicing : Fast-db (Paris)GSHG0016590
Alternative Splicing GalleryENSG00000159399
Gene ExpressionHK2 [ NCBI-GEO ]   HK2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52789 (SRS) P52789 (Uniprot)
NextProtP52789
With graphics : InterProP52789
Splice isoforms : SwissVarP52789(Swissvar)
Domaine pattern : Prosite (SRS)HEXOKINASES (PS00378)   
Domaine pattern : Prosite (Expaxy)HEXOKINASES (PS00378)   
Domains : Interpro (SRS)Hexokinase    Hexokinase_C    Hexokinase_CS    Hexokinase_N   
Domains : Interpro (EBI)Hexokinase    Hexokinase_C    Hexokinase_CS    Hexokinase_N   
Related proteins : CluSTrP52789
Domain families : Pfam (SRS)Hexokinase_1 (PF00349)    Hexokinase_2 (PF03727)   
Domain families : Pfam (Sanger)Hexokinase_1 (PF00349)    Hexokinase_2 (PF03727)   
Domain families : Pfam (NCBI)pfam00349    pfam03727   
DMDM3099
Blocks (Seattle)P52789
PDB (SRS)2NZT   
PDB (PDBSum)2NZT   
PDB (IMB)2NZT   
PDB (RSDB)2NZT   
Human Protein AtlasENSG00000159399
HPRD03080
IPIIPI00102864   IPI00917193   
Protein Interaction databases
DIP (DOE-UCLA)P52789
IntAct (EBI)P52789
FunCoupENSG00000159399
REACTOMEHK2
Protein Interaction Database3099
BioGRIDHK2
InParanoidP52789
Interologous Interaction database P52789
IntegromeDBHK2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)HK2
SNP (GeneSNP Utah)HK2
SNP : HGBaseHK2
Genetic variants : HAPMAPHK2
Somatic Mutations in Cancer : COSMICHK2 
CONAN: Copy Number AnalysisHK2 
Mutations and Diseases : HGMDHK2
OMIM601125   
GENETests601125   
Disease Genetic AssociationHK2
Huge Navigator HK2 [HugePedia]  HK2 [HugeCancerGEM]
Genomic VariantsHK2  HK2 [DGVbeta]
snp3D : Map Gene to Disease3099
General knowledge
Homologs : HomoloGeneHK2
Homology/Alignments : Family Browser (UCSC)HK2
Phylogenetic Trees/Animal Genes : TreeFamHK2
Catalytic activity : Enzyme2.7.1.1 [ Enzyme-Expasy ]   2.7.1.1 [ Enzyme-SRS ]   2.7.1.1 [ IntEnz-EBI ]   2.7.1.1 [ BRENDA ]   2.7.1.1 [ KEGG ]   
Chemical/Protein Interactions : CTD3099
Chemical/Pharm GKB GenePA29301
Clinical trialHK2
Cancer Resource (Charite)ENSG00000159399
Ontology : AmiGOcellular glucose homeostasis  glucokinase activity  hexokinase activity  ATP binding  glucose binding  mitochondrial outer membrane  cytosol  carbohydrate metabolic process  glycolysis  lactation  apoptotic mitochondrial changes  hexose transport  fructokinase activity  glucose transport  mannokinase activity  small molecule metabolic process  regulation of glucose import  glucose 6-phosphate metabolic process  transmembrane transport  
Ontology : EGO-EBIcellular glucose homeostasis  glucokinase activity  hexokinase activity  ATP binding  glucose binding  mitochondrial outer membrane  cytosol  carbohydrate metabolic process  glycolysis  lactation  apoptotic mitochondrial changes  hexose transport  fructokinase activity  glucose transport  mannokinase activity  small molecule metabolic process  regulation of glucose import  glucose 6-phosphate metabolic process  transmembrane transport  
Pathways : KEGGFructose and mannose metabolismStarch and sucrose metabolismAminosugars metabolismStreptomycin biosynthesisGalactose metabolismGlycolysis / Gluconeogenesis
Other databases
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
PubGeneHK2
iHOPHK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:25:34 CEST 2013
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