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HLA-DOA (major histocompatibility complex, class II, DO alpha)

Identity

Alias_namesHLA-DZA
HLA-DNA
Alias_symbol (synonym)HLA-D0-alpha
Other aliasHLADZ
HGNC (Hugo) HLA-DOA
LocusID (NCBI) 3111
Atlas_Id 43624
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 33004183 and ends at 33009612 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLA-DOA (6p21.32) / HLA-DOA (6p21.32)HLA-DOA (6p21.32) / MUC21 (6p21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Squamous Cell Carcinoma
HLA-DOA/MUC21 (6p21)


External links

Nomenclature
HGNC (Hugo)HLA-DOA   4936
Cards
Entrez_Gene (NCBI)HLA-DOA  3111  major histocompatibility complex, class II, DO alpha
AliasesHLA-DNA; HLA-DZA; HLADZ
GeneCards (Weizmann)HLA-DOA
Ensembl hg19 (Hinxton)ENSG00000204252 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204252 [Gene_View]  ENSG00000204252 [Sequence]  chr6:33004183-33009612 [Contig_View]  HLA-DOA [Vega]
ICGC DataPortalENSG00000204252
TCGA cBioPortalHLA-DOA
AceView (NCBI)HLA-DOA
Genatlas (Paris)HLA-DOA
WikiGenes3111
SOURCE (Princeton)HLA-DOA
Genetics Home Reference (NIH)HLA-DOA
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-DOA  -     chr6:33004183-33009612 -  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-DOA  -     6p21.32   [Description]    (hg19-Feb_2009)
EnsemblHLA-DOA - 6p21.32 [CytoView hg19]  HLA-DOA - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIHLA-DOA [Mapview hg19]  HLA-DOA [Mapview hg38]
OMIM142930   
Gene and transcription
Genbank (Entrez)AJ420585 AK290714 AK301404 AK310153 AK313551
RefSeq transcript (Entrez)NM_002119
RefSeq genomic (Entrez)NC_000006 NG_012007 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)HLA-DOA
Cluster EST : UnigeneHs.631991 [ NCBI ]
CGAP (NCI)Hs.631991
Alternative Splicing GalleryENSG00000204252
Gene ExpressionHLA-DOA [ NCBI-GEO ]   HLA-DOA [ EBI - ARRAY_EXPRESS ]   HLA-DOA [ SEEK ]   HLA-DOA [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-DOA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3111
GTEX Portal (Tissue expression)HLA-DOA
Human Protein AtlasENSG00000204252-HLA-DOA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06340   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06340  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06340
Splice isoforms : SwissVarP06340
PhosPhoSitePlusP06340
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_a_N   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_alpha (PF00993)   
Domain families : Pfam (NCBI)pfam07654    pfam00993   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_alpha (SM00920)  
Conserved Domain (NCBI)HLA-DOA
DMDM Disease mutations3111
Blocks (Seattle)HLA-DOA
PDB (SRS)4I0P   
PDB (PDBSum)4I0P   
PDB (IMB)4I0P   
PDB (RSDB)4I0P   
Structural Biology KnowledgeBase4I0P   
SCOP (Structural Classification of Proteins)4I0P   
CATH (Classification of proteins structures)4I0P   
SuperfamilyP06340
Human Protein Atlas [tissue]ENSG00000204252-HLA-DOA [tissue]
Peptide AtlasP06340
HPRD00837
IPIIPI00026244   IPI00908819   IPI00941292   IPI00647554   IPI00872000   IPI00930101   IPI00893209   
Protein Interaction databases
DIP (DOE-UCLA)P06340
IntAct (EBI)P06340
FunCoupENSG00000204252
BioGRIDHLA-DOA
STRING (EMBL)HLA-DOA
ZODIACHLA-DOA
Ontologies - Pathways
QuickGOP06340
Ontology : AmiGOnegative regulation of antigen processing and presentation of peptide antigen via MHC class II  protein binding  lysosomal membrane  plasma membrane  immune response  endosome membrane  integral component of membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  MHC class II protein complex binding  MHC class II receptor activity  MHC class II protein complex  regulation of T cell differentiation  
Ontology : EGO-EBInegative regulation of antigen processing and presentation of peptide antigen via MHC class II  protein binding  lysosomal membrane  plasma membrane  immune response  endosome membrane  integral component of membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  MHC class II protein complex binding  MHC class II receptor activity  MHC class II protein complex  regulation of T cell differentiation  
Pathways : KEGGPhagosome    Cell adhesion molecules (CAMs)    Antigen processing and presentation    Intestinal immune network for IgA production    Type I diabetes mellitus    Leishmaniasis    Toxoplasmosis    Staphylococcus aureus infection    Tuberculosis    Influenza A    HTLV-I infection    Herpes simplex infection    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Systemic lupus erythematosus    Rheumatoid arthritis    Allograft rejection    Graft-versus-host disease    Viral myocarditis   
NDEx NetworkHLA-DOA
Atlas of Cancer Signalling NetworkHLA-DOA
Wikipedia pathwaysHLA-DOA
Orthology - Evolution
OrthoDB3111
GeneTree (enSembl)ENSG00000204252
Phylogenetic Trees/Animal Genes : TreeFamHLA-DOA
HOVERGENP06340
HOGENOMP06340
Homologs : HomoloGeneHLA-DOA
Homology/Alignments : Family Browser (UCSC)HLA-DOA
Gene fusions - Rearrangements
Fusion : MitelmanHLA-DOA/MUC21 [6p21.32/6p21.33]  
Fusion : QuiverHLA-DOA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-DOA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-DOA
dbVarHLA-DOA
ClinVarHLA-DOA
1000_GenomesHLA-DOA 
Exome Variant ServerHLA-DOA
ExAC (Exome Aggregation Consortium)ENSG00000204252
GNOMAD BrowserENSG00000204252
Varsome BrowserHLA-DOA
Genetic variants : HAPMAP3111
Genomic Variants (DGV)HLA-DOA [DGVbeta]
DECIPHERHLA-DOA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-DOA 
Mutations
ICGC Data PortalHLA-DOA 
TCGA Data PortalHLA-DOA 
Broad Tumor PortalHLA-DOA
OASIS PortalHLA-DOA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLA-DOA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHLA-DOA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HLA-DOA
DgiDB (Drug Gene Interaction Database)HLA-DOA
DoCM (Curated mutations)HLA-DOA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-DOA (select a term)
intoGenHLA-DOA
Cancer3DHLA-DOA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142930   
Orphanet
DisGeNETHLA-DOA
MedgenHLA-DOA
Genetic Testing Registry HLA-DOA
NextProtP06340 [Medical]
TSGene3111
GENETestsHLA-DOA
Target ValidationHLA-DOA
Huge Navigator HLA-DOA [HugePedia]
snp3D : Map Gene to Disease3111
BioCentury BCIQHLA-DOA
ClinGenHLA-DOA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3111
Chemical/Pharm GKB GenePA35060
Clinical trialHLA-DOA
Miscellaneous
canSAR (ICR)HLA-DOA (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-DOA
EVEXHLA-DOA
GoPubMedHLA-DOA
iHOPHLA-DOA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:11:09 CET 2018

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