HLA-DRA (major histocompatibility complex, class II, DR alpha)

2007-02-01 Affiliation

Identity

HGNC

HLA-DRA

LOCATION

6p21.32

LOCUSID

3122

ALIAS

HLA-DRA1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3122
MIM: 142860
HGNC: 4947
Ensembl: ENSG00000204287

Variants:

dbSNP: 3122
ClinVar: 3122
TCGA: ENSG00000204287
COSMIC: HLA-DRA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204287	ENST00000374982	Q30118
ENSG00000204287	ENST00000395388	P01903

Expression (GTEx)

500

1000

1500

2000

2500

3000

3500

4000

4500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Antigen processing and presentation	KEGG	ko04612
Hematopoietic cell lineage	KEGG	ko04640
Type I diabetes mellitus	KEGG	ko04940
Asthma	KEGG	ko05310
Autoimmune thyroid disease	KEGG	ko05320
Systemic lupus erythematosus	KEGG	ko05322
Allograft rejection	KEGG	ko05330
Graft-versus-host disease	KEGG	ko05332
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Antigen processing and presentation	KEGG	hsa04612
Hematopoietic cell lineage	KEGG	hsa04640
Type I diabetes mellitus	KEGG	hsa04940
Asthma	KEGG	hsa05310
Autoimmune thyroid disease	KEGG	hsa05320
Systemic lupus erythematosus	KEGG	hsa05322
Allograft rejection	KEGG	hsa05330
Graft-versus-host disease	KEGG	hsa05332
Viral myocarditis	KEGG	hsa05416
Intestinal immune network for IgA production	KEGG	ko04672
Intestinal immune network for IgA production	KEGG	hsa04672
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Staphylococcus aureus infection	KEGG	ko05150
Staphylococcus aureus infection	KEGG	hsa05150
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Phosphorylation of CD3 and TCR zeta chains	REACTOME	R-HSA-202427
Translocation of ZAP-70 to Immunological synapse	REACTOME	R-HSA-202430
Generation of second messenger molecules	REACTOME	R-HSA-202433
Downstream TCR signaling	REACTOME	R-HSA-202424
Costimulation by the CD28 family	REACTOME	R-HSA-388841
PD-1 signaling	REACTOME	R-HSA-389948
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon gamma signaling	REACTOME	R-HSA-877300
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164742987	clavulanate	Chemical	VariantAnnotation	associated	PD	30664875
PA164781042	flucloxacillin	Chemical	VariantAnnotation	associated	PD	30664875
PA166119041	drug-induced liver injury	Disease	VariantAnnotation	associated	PD	30664875
PA448406	amoxicillin	Chemical	VariantAnnotation	associated	PD	30664875

References

Pubmed ID	Year	Title	Citations
17660530	2007	Risk alleles for multiple sclerosis identified by a genomewide study.	549
20711177	2010	Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.	266
20362271	2010	Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.	184
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19204726	2009	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	63
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	51
19247692	2009	Analyses of associations with asthma in four asthma population samples from Canada and Australia.	39
21282653	2011	Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions.	33
19047245	2008	HLA-A33 is associated with susceptibility to enterovirus 71 infection.	27
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27

Citation

Dessen P

HLA-DRA (major histocompatibility complex, class II, DR alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46550/hla-dra