HPN (hepsin)

2003-02-01  

Identity

HGNC
HPN
LOCATION
19q13.11
LOCUSID
3249
ALIAS
TMPRSS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3249
MIM: 142440
HGNC: 5155
Ensembl: ENSG00000105707

Variants:

dbSNP: 3249
ClinVar: 3249
TCGA: ENSG00000105707
COSMIC: HPN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105707ENST00000262626P05981
ENSG00000105707ENST00000262626A0A140VJK9
ENSG00000105707ENST00000392226P05981
ENSG00000105707ENST00000392226A0A140VJK9
ENSG00000105707ENST00000597419M0QZ63
ENSG00000105707ENST00000600390M0R244
ENSG00000105707ENST00000672452A0A140VJK9
ENSG00000105707ENST00000673426A0A140VJK9

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Signal TransductionREACTOMER-HSA-162582
Signaling by MST1REACTOMER-HSA-8852405
Signaling by METREACTOMER-HSA-6806834
MET Receptor ActivationREACTOMER-HSA-6806942

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
157928012005Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.50
200150502010Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA.38
187840722008Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression.34
169085242006Pro-urokinase-type plasminogen activator is a substrate for hepsin.22
266738902015The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.22
126293512003Hepsin and maspin are inversely expressed in laser capture microdissectioned prostate cancer.19
173095992007Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma.19
218759332011Proteolytic activation of pro-macrophage-stimulating protein by hepsin.19
217506522011Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells.17
199112552010Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor.16

Citation

Dessen P

HPN (hepsin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40857/hpn