HRH2 (histamine receptor H2)

2007-02-01 Affiliation

Identity

HGNC

HRH2

LOCATION

5q35.2

LOCUSID

3274

ALIAS

H2R,HH2R

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3274
MIM: 142703
HGNC: 5183
Ensembl: ENSG00000113749

Variants:

dbSNP: 3274
ClinVar: 3274
TCGA: ENSG00000113749
COSMIC: HRH2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000113749	ENST00000231683	P25021
ENSG00000113749	ENST00000377291	P25021
ENSG00000113749	ENST00000624694	A0A1B0GVZ0
ENSG00000113749	ENST00000636584	A0A1B0GTK7

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Histamine receptors	REACTOME	R-HSA-390650
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA134890823	PIK3R5	Gene	Pathway	associated
PA175	GNAS	Gene	Pathway	associated
PA33304	PIK3C2A	Gene	Pathway	associated
PA33305	PIK3C2B	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
22169095	2012	Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.	64
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
23465664	2013	Histamine receptor 2 modifies dendritic cell responses to microbial ligands.	32
16203768	2005	The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer.	28
17627982	2007	Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors.	28
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
16888049	2006	H1 and H2 receptors mediate postexercise hyperemia in sedentary and endurance exercise-trained men and women.	24
19193342	2008	Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study.	22
18258331	2008	Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine.	18

Citation

Dessen P

HRH2 (histamine receptor H2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43658/hrh2