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HRH3 (histamine receptor H3)

Identity

Alias_symbol (synonym)GPCR97
Other aliasHH3R
HGNC (Hugo) HRH3
LocusID (NCBI) 11255
Atlas_Id 50307
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 62214961 and ends at 62220267 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NRGN (11q24.2) / HRH3 (20q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HRH3   5184
Cards
Entrez_Gene (NCBI)HRH3  11255  histamine receptor H3
AliasesGPCR97; HH3R
GeneCards (Weizmann)HRH3
Ensembl hg19 (Hinxton)ENSG00000101180 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101180 [Gene_View]  chr20:62214961-62220267 [Contig_View]  HRH3 [Vega]
ICGC DataPortalENSG00000101180
TCGA cBioPortalHRH3
AceView (NCBI)HRH3
Genatlas (Paris)HRH3
WikiGenes11255
SOURCE (Princeton)HRH3
Genetics Home Reference (NIH)HRH3
Genomic and cartography
GoldenPath hg38 (UCSC)HRH3  -     chr20:62214961-62220267 -  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HRH3  -     20q13.33   [Description]    (hg19-Feb_2009)
EnsemblHRH3 - 20q13.33 [CytoView hg19]  HRH3 - 20q13.33 [CytoView hg38]
Mapping of homologs : NCBIHRH3 [Mapview hg19]  HRH3 [Mapview hg38]
OMIM604525   
Gene and transcription
Genbank (Entrez)AB019000 AF140538 AF321910 AF321911 AF321912
RefSeq transcript (Entrez)NM_007232
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HRH3
Cluster EST : UnigeneHs.251399 [ NCBI ]
CGAP (NCI)Hs.251399
Alternative Splicing GalleryENSG00000101180
Gene ExpressionHRH3 [ NCBI-GEO ]   HRH3 [ EBI - ARRAY_EXPRESS ]   HRH3 [ SEEK ]   HRH3 [ MEM ]
Gene Expression Viewer (FireBrowse)HRH3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11255
GTEX Portal (Tissue expression)HRH3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5N1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5N1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5N1
Splice isoforms : SwissVarQ9Y5N1
PhosPhoSitePlusQ9Y5N1
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Histamine_H3_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)HRH3
DMDM Disease mutations11255
Blocks (Seattle)HRH3
SuperfamilyQ9Y5N1
Human Protein AtlasENSG00000101180
Peptide AtlasQ9Y5N1
IPIIPI00027012   IPI00217217   IPI00217219   IPI00217220   IPI00217221   IPI00217222   IPI00169339   IPI00419955   IPI00217218   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5N1
IntAct (EBI)Q9Y5N1
FunCoupENSG00000101180
BioGRIDHRH3
STRING (EMBL)HRH3
ZODIACHRH3
Ontologies - Pathways
QuickGOQ9Y5N1
Ontology : AmiGOhistamine receptor activity  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  neurotransmitter secretion  negative regulation of glutamate secretion  regulation of norepinephrine secretion  negative regulation of serotonin secretion  cognition  presynapse  
Ontology : EGO-EBIhistamine receptor activity  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  neurotransmitter secretion  negative regulation of glutamate secretion  regulation of norepinephrine secretion  negative regulation of serotonin secretion  cognition  presynapse  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkHRH3
Atlas of Cancer Signalling NetworkHRH3
Wikipedia pathwaysHRH3
Orthology - Evolution
OrthoDB11255
GeneTree (enSembl)ENSG00000101180
Phylogenetic Trees/Animal Genes : TreeFamHRH3
HOVERGENQ9Y5N1
HOGENOMQ9Y5N1
Homologs : HomoloGeneHRH3
Homology/Alignments : Family Browser (UCSC)HRH3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHRH3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HRH3
dbVarHRH3
ClinVarHRH3
1000_GenomesHRH3 
Exome Variant ServerHRH3
ExAC (Exome Aggregation Consortium)HRH3 (select the gene name)
Genetic variants : HAPMAP11255
Genomic Variants (DGV)HRH3 [DGVbeta]
DECIPHERHRH3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHRH3 
Mutations
ICGC Data PortalHRH3 
TCGA Data PortalHRH3 
Broad Tumor PortalHRH3
OASIS PortalHRH3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHRH3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHRH3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HRH3
DgiDB (Drug Gene Interaction Database)HRH3
DoCM (Curated mutations)HRH3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HRH3 (select a term)
intoGenHRH3
Cancer3DHRH3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604525   
Orphanet
MedgenHRH3
Genetic Testing Registry HRH3
NextProtQ9Y5N1 [Medical]
TSGene11255
GENETestsHRH3
Target ValidationHRH3
Huge Navigator HRH3 [HugePedia]
snp3D : Map Gene to Disease11255
BioCentury BCIQHRH3
ClinGenHRH3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11255
Chemical/Pharm GKB GenePA29458
Clinical trialHRH3
Miscellaneous
canSAR (ICR)HRH3 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHRH3
EVEXHRH3
GoPubMedHRH3
iHOPHRH3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:37:31 CEST 2017

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