HRH3 (histamine receptor H3)

2008-08-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
GPCR97,HH3R
FUSION GENES

Other Information

Locus ID:

NCBI: 11255
MIM: 604525
HGNC: 5184
Ensembl: ENSG00000101180

Variants:

dbSNP: 11255
ClinVar: 11255
TCGA: ENSG00000101180
COSMIC: HRH3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101180ENST00000317393A0A0A0MR48
ENSG00000101180ENST00000340177Q9Y5N1
ENSG00000101180ENST00000611492A0A087WZD3

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Histamine receptorsREACTOMER-HSA-390650
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD21652606
PA451257risperidoneChemicalClinicalAnnotationassociatedPD21652606

References

Pubmed IDYearTitleCitations
156658572005The histamine H3 receptor: from gene cloning to H3 receptor drugs.71
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
194135722009Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors.43
165654702006Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders.32
176279822007Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors.28
198259892009H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.28
191933422008Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study.22
208645032011The histamine H3 receptor and eating behavior.17
221189422012Alterations in the histaminergic system in the substantia nigra and striatum of Parkinson's patients: a postmortem study.17
117523972002Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings.16

Citation

Dessen P

HRH3 (histamine receptor H3)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50307/hrh3