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HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7)

Identity

Alias (NCBI)PRAP
SDR37C1
HGNC (Hugo) HSD17B7
HGNC Alias symbPRAP
SDR37C1
HGNC Alias nameshort chain dehydrogenase/reductase family 37C, member 1
HGNC Previous namehydroxysteroid (17-beta) dehydrogenase 7
LocusID (NCBI) 51478
Atlas_Id 40869
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 162790702 and ends at 162812818 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HSD17B7   5215
Cards
Entrez_Gene (NCBI)HSD17B7    hydroxysteroid 17-beta dehydrogenase 7
AliasesPRAP; SDR37C1
GeneCards (Weizmann)HSD17B7
Ensembl hg19 (Hinxton)ENSG00000132196 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132196 [Gene_View]  ENSG00000132196 [Sequence]  chr1:162790702-162812818 [Contig_View]  HSD17B7 [Vega]
ICGC DataPortalENSG00000132196
TCGA cBioPortalHSD17B7
AceView (NCBI)HSD17B7
Genatlas (Paris)HSD17B7
SOURCE (Princeton)HSD17B7
Genetics Home Reference (NIH)HSD17B7
Genomic and cartography
GoldenPath hg38 (UCSC)HSD17B7  -     chr1:162790702-162812818 +  1q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSD17B7  -     1q23.3   [Description]    (hg19-Feb_2009)
GoldenPathHSD17B7 - 1q23.3 [CytoView hg19]  HSD17B7 - 1q23.3 [CytoView hg38]
ImmunoBaseENSG00000132196
Genome Data Viewer NCBIHSD17B7 [Mapview hg19]  
OMIM606756   
Gene and transcription
Genbank (Entrez)AF098786 AF145023 AJ249179 AK022929 AK290741
RefSeq transcript (Entrez)NM_001304512 NM_001304513 NM_016371
Consensus coding sequences : CCDS (NCBI)HSD17B7
Gene ExpressionHSD17B7 [ NCBI-GEO ]   HSD17B7 [ EBI - ARRAY_EXPRESS ]   HSD17B7 [ SEEK ]   HSD17B7 [ MEM ]
Gene Expression Viewer (FireBrowse)HSD17B7 [ Firebrowse - Broad ]
GenevisibleExpression of HSD17B7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51478
GTEX Portal (Tissue expression)HSD17B7
Human Protein AtlasENSG00000132196-HSD17B7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56937   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56937  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56937
PhosPhoSitePlusP56937
Domains : Interpro (EBI)HSD17B7/Erg27    NAD(P)-bd_dom_sf    SDR_fam   
Domain families : Pfam (Sanger)adh_short (PF00106)   
Domain families : Pfam (NCBI)pfam00106   
Conserved Domain (NCBI)HSD17B7
SuperfamilyP56937
AlphaFold pdb e-kbP56937   
Human Protein Atlas [tissue]ENSG00000132196-HSD17B7 [tissue]
HPRD05996
Protein Interaction databases
DIP (DOE-UCLA)P56937
IntAct (EBI)P56937
BioGRIDHSD17B7
STRING (EMBL)HSD17B7
ZODIACHSD17B7
Ontologies - Pathways
QuickGOP56937
Ontology : AmiGO3-keto sterol reductase activity  3-keto sterol reductase activity  estradiol 17-beta-dehydrogenase activity  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  cholesterol biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  estrogen biosynthetic process  estrogen biosynthetic process  androgen metabolic process  integral component of membrane  5alpha-androstane-3beta,17beta-diol dehydrogenase activity  17-beta-hydroxysteroid dehydrogenase (NADP+) activity  
Ontology : EGO-EBI3-keto sterol reductase activity  3-keto sterol reductase activity  estradiol 17-beta-dehydrogenase activity  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  cholesterol biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  estrogen biosynthetic process  estrogen biosynthetic process  androgen metabolic process  integral component of membrane  5alpha-androstane-3beta,17beta-diol dehydrogenase activity  17-beta-hydroxysteroid dehydrogenase (NADP+) activity  
Pathways : KEGGSteroid biosynthesis    Steroid hormone biosynthesis    Ovarian steroidogenesis   
NDEx NetworkHSD17B7
Atlas of Cancer Signalling NetworkHSD17B7
Wikipedia pathwaysHSD17B7
Orthology - Evolution
OrthoDB51478
GeneTree (enSembl)ENSG00000132196
Phylogenetic Trees/Animal Genes : TreeFamHSD17B7
Homologs : HomoloGeneHSD17B7
Homology/Alignments : Family Browser (UCSC)HSD17B7
Gene fusions - Rearrangements
Fusion : QuiverHSD17B7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSD17B7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSD17B7
dbVarHSD17B7
ClinVarHSD17B7
MonarchHSD17B7
1000_GenomesHSD17B7 
Exome Variant ServerHSD17B7
GNOMAD BrowserENSG00000132196
Varsome BrowserHSD17B7
ACMGHSD17B7 variants
VarityP56937
Genomic Variants (DGV)HSD17B7 [DGVbeta]
DECIPHERHSD17B7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSD17B7 
Mutations
ICGC Data PortalHSD17B7 
TCGA Data PortalHSD17B7 
Broad Tumor PortalHSD17B7
OASIS PortalHSD17B7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSD17B7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHSD17B7
Mutations and Diseases : HGMDHSD17B7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHSD17B7
DgiDB (Drug Gene Interaction Database)HSD17B7
DoCM (Curated mutations)HSD17B7
CIViC (Clinical Interpretations of Variants in Cancer)HSD17B7
Cancer3DHSD17B7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606756   
Orphanet
DisGeNETHSD17B7
MedgenHSD17B7
Genetic Testing Registry HSD17B7
NextProtP56937 [Medical]
GENETestsHSD17B7
Target ValidationHSD17B7
Huge Navigator HSD17B7 [HugePedia]
ClinGenHSD17B7
Clinical trials, drugs, therapy
MyCancerGenomeHSD17B7
Protein Interactions : CTDHSD17B7
Pharm GKB GenePA29483
PharosP56937
Clinical trialHSD17B7
Miscellaneous
canSAR (ICR)HSD17B7
HarmonizomeHSD17B7
DataMed IndexHSD17B7
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHSD17B7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:04 CEST 2021

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