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HSPBP1 (HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1)

Identity

Alias_namesHSPA (heat shock 70kDa) binding protein
Alias_symbol (synonym)HspBP1
FES1
Other alias
HGNC (Hugo) HSPBP1
LocusID (NCBI) 23640
Atlas_Id 46091
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 55773591 and ends at 55791751 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HSPA13 (21q11.2) / HSPBP1 (19q13.42)HSPBP1 (19q13.42) / HSPBP1 (19q13.42)HSPBP1 (19q13.42) / SF3B2 (11q13.1)
HSPBP1 (19q13.42) / TRIM8 (10q24.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSPBP1   24989
Cards
Entrez_Gene (NCBI)HSPBP1  23640  HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
AliasesFES1
GeneCards (Weizmann)HSPBP1
Ensembl hg19 (Hinxton)ENSG00000133265 [Gene_View]  chr19:55773591-55791751 [Contig_View]  HSPBP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133265 [Gene_View]  chr19:55773591-55791751 [Contig_View]  HSPBP1 [Vega]
ICGC DataPortalENSG00000133265
TCGA cBioPortalHSPBP1
AceView (NCBI)HSPBP1
Genatlas (Paris)HSPBP1
WikiGenes23640
SOURCE (Princeton)HSPBP1
Genetics Home Reference (NIH)HSPBP1
Genomic and cartography
GoldenPath hg19 (UCSC)HSPBP1  -     chr19:55773591-55791751 -  19q13.42   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HSPBP1  -     19q13.42   [Description]    (hg38-Dec_2013)
EnsemblHSPBP1 - 19q13.42 [CytoView hg19]  HSPBP1 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBIHSPBP1 [Mapview hg19]  HSPBP1 [Mapview hg38]
OMIM612939   
Gene and transcription
Genbank (Entrez)AB020592 AF093420 AF187859 AF217996 AI859141
RefSeq transcript (Entrez)NM_001130106 NM_001297600 NM_012267
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)HSPBP1
Cluster EST : UnigeneHs.53066 [ NCBI ]
CGAP (NCI)Hs.53066
Alternative Splicing GalleryENSG00000133265
Gene ExpressionHSPBP1 [ NCBI-GEO ]   HSPBP1 [ EBI - ARRAY_EXPRESS ]   HSPBP1 [ SEEK ]   HSPBP1 [ MEM ]
Gene Expression Viewer (FireBrowse)HSPBP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23640
GTEX Portal (Tissue expression)HSPBP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZL4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZL4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZL4
Splice isoforms : SwissVarQ9NZL4
PhosPhoSitePlusQ9NZL4
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Nucleotide_exch_fac_Fes1   
Domain families : Pfam (Sanger)Fes1 (PF08609)   
Domain families : Pfam (NCBI)pfam08609   
Conserved Domain (NCBI)HSPBP1
DMDM Disease mutations23640
Blocks (Seattle)HSPBP1
PDB (SRS)1XQR    1XQS   
PDB (PDBSum)1XQR    1XQS   
PDB (IMB)1XQR    1XQS   
PDB (RSDB)1XQR    1XQS   
Structural Biology KnowledgeBase1XQR    1XQS   
SCOP (Structural Classification of Proteins)1XQR    1XQS   
CATH (Classification of proteins structures)1XQR    1XQS   
SuperfamilyQ9NZL4
Human Protein AtlasENSG00000133265
Peptide AtlasQ9NZL4
HPRD09991
IPIIPI00442503   IPI00100748   IPI00953460   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZL4
IntAct (EBI)Q9NZL4
FunCoupENSG00000133265
BioGRIDHSPBP1
STRING (EMBL)HSPBP1
ZODIACHSPBP1
Ontologies - Pathways
QuickGOQ9NZL4
Ontology : AmiGOenzyme inhibitor activity  protein binding  protein folding  positive regulation of protein ubiquitination  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of catalytic activity  
Ontology : EGO-EBIenzyme inhibitor activity  protein binding  protein folding  positive regulation of protein ubiquitination  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of catalytic activity  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkHSPBP1
Atlas of Cancer Signalling NetworkHSPBP1
Wikipedia pathwaysHSPBP1
Orthology - Evolution
OrthoDB23640
GeneTree (enSembl)ENSG00000133265
Phylogenetic Trees/Animal Genes : TreeFamHSPBP1
HOVERGENQ9NZL4
HOGENOMQ9NZL4
Homologs : HomoloGeneHSPBP1
Homology/Alignments : Family Browser (UCSC)HSPBP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPBP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPBP1
dbVarHSPBP1
ClinVarHSPBP1
1000_GenomesHSPBP1 
Exome Variant ServerHSPBP1
ExAC (Exome Aggregation Consortium)HSPBP1 (select the gene name)
Genetic variants : HAPMAP23640
Genomic Variants (DGV)HSPBP1 [DGVbeta]
DECIPHER (Syndromes)19:55773591-55791751  ENSG00000133265
CONAN: Copy Number AnalysisHSPBP1 
Mutations
ICGC Data PortalHSPBP1 
TCGA Data PortalHSPBP1 
Broad Tumor PortalHSPBP1
OASIS PortalHSPBP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPBP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPBP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSPBP1
DgiDB (Drug Gene Interaction Database)HSPBP1
DoCM (Curated mutations)HSPBP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPBP1 (select a term)
intoGenHSPBP1
Cancer3DHSPBP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612939   
Orphanet
MedgenHSPBP1
Genetic Testing Registry HSPBP1
NextProtQ9NZL4 [Medical]
TSGene23640
GENETestsHSPBP1
Huge Navigator HSPBP1 [HugePedia]
snp3D : Map Gene to Disease23640
BioCentury BCIQHSPBP1
ClinGenHSPBP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23640
Chemical/Pharm GKB GenePA164720725
Clinical trialHSPBP1
Miscellaneous
canSAR (ICR)HSPBP1 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPBP1
EVEXHSPBP1
GoPubMedHSPBP1
iHOPHSPBP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:04:30 CEST 2017

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