HTR1B (5-hydroxytryptamine receptor 1B)

2012-06-01 Affiliation

Identity

HGNC

HTR1B

LOCATION

6q14.1

LOCUSID

3351

ALIAS

5-HT-1B,5-HT-1D-beta,5-HT1B,5-HT1DB,HTR1D2,HTR1DB,S12

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3351
MIM: 182131
HGNC: 5287
Ensembl: ENSG00000135312

Variants:

dbSNP: 3351
ClinVar: 3351
TCGA: ENSG00000135312
COSMIC: HTR1B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135312	ENST00000369947	P28222
ENSG00000135312	ENST00000369947	X5D7I5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Taste transduction	KEGG	ko04742
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Taste transduction	KEGG	hsa04742
Serotonergic synapse	KEGG	hsa04726
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Serotonin receptors	REACTOME	R-HSA-390666
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA10074	escitalopram	Chemical	ClinicalAnnotation	associated	PD
PA164778866	liothyronine	Chemical	ClinicalAnnotation	associated	PD	21449676
PA172	GNAI1	Gene	Pathway	associated		19741567
PA173	GNAI3	Gene	Pathway	associated		19741567
PA24347	GNAI2	Gene	Pathway	associated		19741567
PA447196	Anxiety Disorders	Disease	ClinicalAnnotation	associated	PD	27324805
PA447278	Depression	Disease	ClinicalAnnotation	associated	PD	21449676
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	27324805, 28025020
PA449015	citalopram	Chemical	ClinicalAnnotation	associated	PD	27324805
PA449048	clomipramine	Chemical	ClinicalAnnotation	associated	PD	21449676
PA449673	fluoxetine	Chemical	ClinicalAnnotation	associated	PD	28025020
PA450243	lithium	Chemical	ClinicalAnnotation	associated	PD	21449676
PA450603	nefazodone	Chemical	ClinicalAnnotation	associated	PD	21449676
PA450801	paroxetine	Chemical	ClinicalAnnotation	associated		21449676
PA451866	venlafaxine	Chemical	ClinicalAnnotation	associated	PD	21449676

References

Pubmed ID	Year	Title	Citations
18583979	2008	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	395
19506906	2009	Candidate gene studies of ADHD: a meta-analytic review.	263
16400147	2006	Alterations in 5-HT1B receptor function by p11 in depression-like states.	151
23519210	2013	Structural basis for molecular recognition at serotonin receptors.	128
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
14744462	2004	Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.	81
18937842	2008	The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.	63
18283276	2009	A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors.	54
18283276	2009	A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors.	54

Citation

Dessen P

HTR1B (5-hydroxytryptamine receptor 1B)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52736/htr1b