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HTR1B (5-hydroxytryptamine receptor 1B)

Identity

Alias_names5-hydroxytryptamine (serotonin) receptor 1B
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Alias_symbol (synonym)S12
5-HT1B
HTR1D2
5-HT1DB
Other alias5-HT-1B
5-HT-1D-beta
HTR1DB
HGNC (Hugo) HTR1B
LocusID (NCBI) 3351
Atlas_Id 52736
Location 6q14.1  [Link to chromosome band 6q14]
Location_base_pair Starts at 77460848 and ends at 77464022 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HTR1B   5287
Cards
Entrez_Gene (NCBI)HTR1B  3351  5-hydroxytryptamine receptor 1B
Aliases5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB; 
HTR1D2; HTR1DB; S12
GeneCards (Weizmann)HTR1B
Ensembl hg19 (Hinxton)ENSG00000135312 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135312 [Gene_View]  ENSG00000135312 [Sequence]  chr6:77460848-77464022 [Contig_View]  HTR1B [Vega]
ICGC DataPortalENSG00000135312
TCGA cBioPortalHTR1B
AceView (NCBI)HTR1B
Genatlas (Paris)HTR1B
WikiGenes3351
SOURCE (Princeton)HTR1B
Genetics Home Reference (NIH)HTR1B
Genomic and cartography
GoldenPath hg38 (UCSC)HTR1B  -     chr6:77460848-77464022 -  6q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HTR1B  -     6q14.1   [Description]    (hg19-Feb_2009)
EnsemblHTR1B - 6q14.1 [CytoView hg19]  HTR1B - 6q14.1 [CytoView hg38]
Mapping of homologs : NCBIHTR1B [Mapview hg19]  HTR1B [Mapview hg38]
OMIM182131   
Gene and transcription
Genbank (Entrez)AK290080 AK315325 BC069065 BC096206 BC096207
RefSeq transcript (Entrez)NM_000863
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HTR1B
Cluster EST : UnigeneHs.123016 [ NCBI ]
CGAP (NCI)Hs.123016
Alternative Splicing GalleryENSG00000135312
Gene ExpressionHTR1B [ NCBI-GEO ]   HTR1B [ EBI - ARRAY_EXPRESS ]   HTR1B [ SEEK ]   HTR1B [ MEM ]
Gene Expression Viewer (FireBrowse)HTR1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3351
GTEX Portal (Tissue expression)HTR1B
Human Protein AtlasENSG00000135312-HTR1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28222   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28222  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28222
Splice isoforms : SwissVarP28222
PhosPhoSitePlusP28222
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)5HT1B_rcpt    5HT_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)HTR1B
DMDM Disease mutations3351
Blocks (Seattle)HTR1B
PDB (SRS)2G1X    4IAQ    4IAR    5V54   
PDB (PDBSum)2G1X    4IAQ    4IAR    5V54   
PDB (IMB)2G1X    4IAQ    4IAR    5V54   
PDB (RSDB)2G1X    4IAQ    4IAR    5V54   
Structural Biology KnowledgeBase2G1X    4IAQ    4IAR    5V54   
SCOP (Structural Classification of Proteins)2G1X    4IAQ    4IAR    5V54   
CATH (Classification of proteins structures)2G1X    4IAQ    4IAR    5V54   
SuperfamilyP28222
Human Protein Atlas [tissue]ENSG00000135312-HTR1B [tissue]
Peptide AtlasP28222
HPRD01634
IPIIPI00002184   
Protein Interaction databases
DIP (DOE-UCLA)P28222
IntAct (EBI)P28222
FunCoupENSG00000135312
BioGRIDHTR1B
STRING (EMBL)HTR1B
ZODIACHTR1B
Ontologies - Pathways
QuickGOP28222
Ontology : AmiGOG-protein coupled receptor internalization  G-protein coupled receptor activity  G-protein coupled serotonin receptor activity  G-protein coupled serotonin receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting serotonin receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  chemical synaptic transmission  chemical synaptic transmission  drug binding  regulation of dopamine secretion  negative regulation of serotonin secretion  dendrite  neurotransmitter receptor activity  negative regulation of synaptic transmission, GABAergic  cellular response to drug  response to cocaine  vasoconstriction  drinking behavior  response to ethanol  bone remodeling  regulation of behavior  serotonin binding  response to mineralocorticoid  negative regulation of synaptic transmission, glutamatergic  cellular response to alkaloid  cellular response to temperature stimulus  positive regulation of vascular smooth muscle cell proliferation  
Ontology : EGO-EBIG-protein coupled receptor internalization  G-protein coupled receptor activity  G-protein coupled serotonin receptor activity  G-protein coupled serotonin receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting serotonin receptor signaling pathway  protein kinase C-activating G-protein coupled receptor signaling pathway  chemical synaptic transmission  chemical synaptic transmission  drug binding  regulation of dopamine secretion  negative regulation of serotonin secretion  dendrite  neurotransmitter receptor activity  negative regulation of synaptic transmission, GABAergic  cellular response to drug  response to cocaine  vasoconstriction  drinking behavior  response to ethanol  bone remodeling  regulation of behavior  serotonin binding  response to mineralocorticoid  negative regulation of synaptic transmission, glutamatergic  cellular response to alkaloid  cellular response to temperature stimulus  positive regulation of vascular smooth muscle cell proliferation  
Pathways : KEGGNeuroactive ligand-receptor interaction    Serotonergic synapse   
NDEx NetworkHTR1B
Atlas of Cancer Signalling NetworkHTR1B
Wikipedia pathwaysHTR1B
Orthology - Evolution
OrthoDB3351
GeneTree (enSembl)ENSG00000135312
Phylogenetic Trees/Animal Genes : TreeFamHTR1B
HOVERGENP28222
HOGENOMP28222
Homologs : HomoloGeneHTR1B
Homology/Alignments : Family Browser (UCSC)HTR1B
Gene fusions - Rearrangements
Fusion : QuiverHTR1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTR1B
dbVarHTR1B
ClinVarHTR1B
1000_GenomesHTR1B 
Exome Variant ServerHTR1B
ExAC (Exome Aggregation Consortium)ENSG00000135312
GNOMAD BrowserENSG00000135312
Varsome BrowserHTR1B
Genetic variants : HAPMAP3351
Genomic Variants (DGV)HTR1B [DGVbeta]
DECIPHERHTR1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHTR1B 
Mutations
ICGC Data PortalHTR1B 
TCGA Data PortalHTR1B 
Broad Tumor PortalHTR1B
OASIS PortalHTR1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTR1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HTR1B
DgiDB (Drug Gene Interaction Database)HTR1B
DoCM (Curated mutations)HTR1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTR1B (select a term)
intoGenHTR1B
Cancer3DHTR1B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182131   
Orphanet
DisGeNETHTR1B
MedgenHTR1B
Genetic Testing Registry HTR1B
NextProtP28222 [Medical]
TSGene3351
GENETestsHTR1B
Target ValidationHTR1B
Huge Navigator HTR1B [HugePedia]
snp3D : Map Gene to Disease3351
BioCentury BCIQHTR1B
ClinGenHTR1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3351
Chemical/Pharm GKB GenePA29549
Clinical trialHTR1B
Miscellaneous
canSAR (ICR)HTR1B (select the gene name)
Probes
Litterature
PubMed192 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTR1B
EVEXHTR1B
GoPubMedHTR1B
iHOPHTR1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:28:11 CEST 2018

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