Identity
HGNC
LOCATION
6q14.1
LOCUSID
ALIAS
5-HT-1B,5-HT-1D-beta,5-HT1B,5-HT1DB,HTR1D2,HTR1DB,S12
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3351
MIM: 182131
HGNC: 5287
Ensembl: ENSG00000135312
Variants:
dbSNP: 3351
ClinVar: 3351
TCGA: ENSG00000135312
COSMIC: HTR1B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000135312 | ENST00000369947 | P28222 |
| ENSG00000135312 | ENST00000369947 | X5D7I5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10074 | escitalopram | Chemical | ClinicalAnnotation | associated | PD | ||
| PA164778866 | liothyronine | Chemical | ClinicalAnnotation | associated | PD | 21449676 | |
| PA172 | GNAI1 | Gene | Pathway | associated | 19741567 | ||
| PA173 | GNAI3 | Gene | Pathway | associated | 19741567 | ||
| PA24347 | GNAI2 | Gene | Pathway | associated | 19741567 | ||
| PA447196 | Anxiety Disorders | Disease | ClinicalAnnotation | associated | PD | 27324805 | |
| PA447278 | Depression | Disease | ClinicalAnnotation | associated | PD | 21449676 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 27324805, 28025020 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 27324805 | |
| PA449048 | clomipramine | Chemical | ClinicalAnnotation | associated | PD | 21449676 | |
| PA449673 | fluoxetine | Chemical | ClinicalAnnotation | associated | PD | 28025020 | |
| PA450243 | lithium | Chemical | ClinicalAnnotation | associated | PD | 21449676 | |
| PA450603 | nefazodone | Chemical | ClinicalAnnotation | associated | PD | 21449676 | |
| PA450801 | paroxetine | Chemical | ClinicalAnnotation | associated | 21449676 | ||
| PA451866 | venlafaxine | Chemical | ClinicalAnnotation | associated | PD | 21449676 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38050328 | 2024 | The rs6296 polymorphism in the 5-HT1b receptor in Dutch men with lifelong premature ejaculation: a genetic case-control association study. | 0 |
| 38050328 | 2024 | The rs6296 polymorphism in the 5-HT1b receptor in Dutch men with lifelong premature ejaculation: a genetic case-control association study. | 0 |
| 37762136 | 2023 | Synergistic Interaction of 5-HT(1B) and 5-HT(2B) Receptors in Cytoplasmic Ca(2+) Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies. | 1 |
| 37762136 | 2023 | Synergistic Interaction of 5-HT(1B) and 5-HT(2B) Receptors in Cytoplasmic Ca(2+) Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies. | 1 |
| 35438303 | 2022 | Methylation and expression quantitative trait locus rs6296 in the HTR1B gene is associated with susceptibility to opioid use disorder. | 2 |
| 35853382 | 2022 | HTR1B genotype and psychopathy: Main effect and interaction with paternal maltreatment. | 2 |
| 35438303 | 2022 | Methylation and expression quantitative trait locus rs6296 in the HTR1B gene is associated with susceptibility to opioid use disorder. | 2 |
| 35853382 | 2022 | HTR1B genotype and psychopathy: Main effect and interaction with paternal maltreatment. | 2 |
| 32092211 | 2020 | Serotonin system genes and hoarding with and without other obsessive-compulsive traits in a population-based, pediatric sample: A genetic association study. | 3 |
| 32669569 | 2020 | The discovery of a new antibody for BRIL-fused GPCR structure determination. | 12 |
| 32689951 | 2020 | Effects of HTR1B 3' region polymorphisms and functional regions on gene expression regulation. | 2 |
| 33003279 | 2020 | First Evidence of Kv3.1b Potassium Channel Subtype Expression during Neuronal Serotonergic 1C11 Cell Line Development. | 4 |
| 33036580 | 2020 | Functional polymorphisms and transcriptional analysis in the 5' region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders. | 1 |
| 33244961 | 2020 | [The role of genetic factors in the development of suicidal behavior in individuals with dependence on synthetic cathinones]. | 1 |
| 32092211 | 2020 | Serotonin system genes and hoarding with and without other obsessive-compulsive traits in a population-based, pediatric sample: A genetic association study. | 3 |
Citation
Dessen P
HTR1B (5-hydroxytryptamine receptor 1B)
Atlas Genet Cytogenet Oncol Haematol. 2012-06-01
Online version: http://atlasgeneticsoncology.org/gene/52736/htr1b
