HTR1D (5-hydroxytryptamine receptor 1D)

2003-05-01 Affiliation

Identity

HGNC

HTR1D

LOCATION

1p36.12

LOCUSID

3352

ALIAS

5-HT1D,HT1DA,HTR1DA,HTRL,RDC4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3352
MIM: 182133
HGNC: 5289
Ensembl: ENSG00000179546

Variants:

dbSNP: 3352
ClinVar: 3352
TCGA: ENSG00000179546
COSMIC: HTR1D

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000179546	ENST00000374619	P28221

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Taste transduction	KEGG	ko04742
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Taste transduction	KEGG	hsa04742
Serotonergic synapse	KEGG	hsa04726
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Serotonin receptors	REACTOME	R-HSA-390666
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA172	GNAI1	Gene	Pathway	associated	19741567
PA173	GNAI3	Gene	Pathway	associated	19741567
PA24347	GNAI2	Gene	Pathway	associated	19741567

References

Pubmed ID	Year	Title	Citations
21079607	2011	A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.	67
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
17203304	2007	Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels.	42
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
18676680	2008	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	32
20468064	2010	Association study of 182 candidate genes in anorexia nervosa.	30
18855532	2008	Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.	29
19692168	2010	Genetic susceptibility to distinct bladder cancer subphenotypes.	25
12740597	2003	Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.	23
16806108	2007	Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa.	21

Citation

Dessen P

HTR1D (5-hydroxytryptamine receptor 1D)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40898/htr1d