IER5 (immediate early response 5)

2007-04-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
SBBI48

Other Information

Locus ID:

NCBI: 51278
MIM: 607177
HGNC: 5393
Ensembl: ENSG00000162783

Variants:

dbSNP: 51278
ClinVar: 51278
TCGA: ENSG00000162783
COSMIC: IER5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162783ENST00000367577Q5VY09

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
111025862000Gene expression in the brain across the sleep-waking cycle.116
192384192009Induced expression of the IER5 gene by gamma-ray irradiation and its involvement in cell cycle checkpoint control and survival.16
267549252016IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.15
221321932011Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.11
258167512015HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.5
269154042016Transcriptional regulation of IER5 in response to radiation in HepG2.5
253556272015Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells.4
284305892017IER5 as a promising predictive marker promotes irradiation-induced apoptosis in cervical cancer tissues from patients undergoing chemoradiotherapy.3
291044872017IER5 is involved in DNA Double-Strand Breaks Repair in Association with PAPR1 in Hela Cells.3
305992132019IER family proteins are regulators of protein phosphatase PP2A and modulate the phosphorylation status of CDC25A.0

Citation

Dessen P

IER5 (immediate early response 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46759/ier5