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IFI6 (interferon alpha inducible protein 6)

Identity

Alias (NCBI)6-16
FAM14C
G1P3
IFI-6-16
IFI616
HGNC (Hugo) IFI6
HGNC Alias symbIFI616
FAM14C
6-16
IFI-6-16
HGNC Previous nameG1P3
HGNC Previous nameinterferon, alpha-inducible protein (clone IFI-6-16)
LocusID (NCBI) 2537
Atlas_Id 53345
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 27666064 and ends at 27672192 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IFI6 (1p36.11) / CTNS (17p13.2)IFI6 (1p36.11) / MAFF (22q13.1)IFI6 (1p36.11) / PRSS8 (16p11.2)
IFI6 (1p36.11) / SERINC1 (6q22.31)IFI6 (1p36.11) / STPG1 (1p36.11)IFI6 (1p36.11) / TNRC18 (7p22.1)
IFI6 1p36.11 C1orf201

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IFI6   4054
Cards
Entrez_Gene (NCBI)IFI6    interferon alpha inducible protein 6
Aliases6-16; FAM14C; G1P3; IFI-6-16; 
IFI616
GeneCards (Weizmann)IFI6
Ensembl hg19 (Hinxton)ENSG00000126709 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126709 [Gene_View]  ENSG00000126709 [Sequence]  chr1:27666064-27672192 [Contig_View]  IFI6 [Vega]
ICGC DataPortalENSG00000126709
TCGA cBioPortalIFI6
AceView (NCBI)IFI6
Genatlas (Paris)IFI6
SOURCE (Princeton)IFI6
Genetics Home Reference (NIH)IFI6
Genomic and cartography
GoldenPath hg38 (UCSC)IFI6  -     chr1:27666064-27672192 -  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFI6  -     1p35.3   [Description]    (hg19-Feb_2009)
GoldenPathIFI6 - 1p35.3 [CytoView hg19]  IFI6 - 1p35.3 [CytoView hg38]
ImmunoBaseENSG00000126709
Genome Data Viewer NCBIIFI6 [Mapview hg19]  
OMIM147572   
Gene and transcription
Genbank (Entrez)AF430686 AK024814 AK314488 BC011601 BC015603
RefSeq transcript (Entrez)NM_002038 NM_022872 NM_022873
Consensus coding sequences : CCDS (NCBI)IFI6
Gene ExpressionIFI6 [ NCBI-GEO ]   IFI6 [ EBI - ARRAY_EXPRESS ]   IFI6 [ SEEK ]   IFI6 [ MEM ]
Gene Expression Viewer (FireBrowse)IFI6 [ Firebrowse - Broad ]
GenevisibleExpression of IFI6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2537
GTEX Portal (Tissue expression)IFI6
Human Protein AtlasENSG00000126709-IFI6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09912   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09912  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09912
PhosPhoSitePlusP09912
Domains : Interpro (EBI)IFI6/IFI27-like    IFI6/IFI27-like_sf   
Domain families : Pfam (Sanger)Ifi-6-16 (PF06140)   
Domain families : Pfam (NCBI)pfam06140   
Conserved Domain (NCBI)IFI6
SuperfamilyP09912
AlphaFold pdb e-kbP09912   
Human Protein Atlas [tissue]ENSG00000126709-IFI6 [tissue]
HPRD00959
Protein Interaction databases
DIP (DOE-UCLA)P09912
IntAct (EBI)P09912
BioGRIDIFI6
STRING (EMBL)IFI6
ZODIACIFI6
Ontologies - Pathways
QuickGOP09912
Ontology : AmiGOrelease of cytochrome c from mitochondria  protein binding  mitochondrion  mitochondrion  mitochondrial inner membrane  plasma membrane  apoptotic process  immune response  integral component of membrane  mitochondrial membrane  regulation of epidermal growth factor receptor signaling pathway  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  innate immune response  defense response to virus  negative regulation of mitochondrial depolarization  negative regulation of mitochondrial depolarization  type I interferon signaling pathway  reactive oxygen species metabolic process  apoptotic signaling pathway  intrinsic apoptotic signaling pathway  cellular response to virus  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIrelease of cytochrome c from mitochondria  protein binding  mitochondrion  mitochondrion  mitochondrial inner membrane  plasma membrane  apoptotic process  immune response  integral component of membrane  mitochondrial membrane  regulation of epidermal growth factor receptor signaling pathway  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  innate immune response  defense response to virus  negative regulation of mitochondrial depolarization  negative regulation of mitochondrial depolarization  type I interferon signaling pathway  reactive oxygen species metabolic process  apoptotic signaling pathway  intrinsic apoptotic signaling pathway  cellular response to virus  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
NDEx NetworkIFI6
Atlas of Cancer Signalling NetworkIFI6
Wikipedia pathwaysIFI6
Orthology - Evolution
OrthoDB2537
GeneTree (enSembl)ENSG00000126709
Phylogenetic Trees/Animal Genes : TreeFamIFI6
Homologs : HomoloGeneIFI6
Homology/Alignments : Family Browser (UCSC)IFI6
Gene fusions - Rearrangements
Fusion : MitelmanIFI6/STPG1 [1p36.11/1p36.11]  
Fusion : QuiverIFI6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFI6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFI6
dbVarIFI6
ClinVarIFI6
MonarchIFI6
1000_GenomesIFI6 
Exome Variant ServerIFI6
GNOMAD BrowserENSG00000126709
Varsome BrowserIFI6
ACMGIFI6 variants
VarityP09912
Genomic Variants (DGV)IFI6 [DGVbeta]
DECIPHERIFI6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFI6 
Mutations
ICGC Data PortalIFI6 
TCGA Data PortalIFI6 
Broad Tumor PortalIFI6
OASIS PortalIFI6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFI6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIFI6
Mutations and Diseases : HGMDIFI6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIFI6
DgiDB (Drug Gene Interaction Database)IFI6
DoCM (Curated mutations)IFI6
CIViC (Clinical Interpretations of Variants in Cancer)IFI6
Cancer3DIFI6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147572   
Orphanet
DisGeNETIFI6
MedgenIFI6
Genetic Testing Registry IFI6
NextProtP09912 [Medical]
GENETestsIFI6
Target ValidationIFI6
Huge Navigator IFI6 [HugePedia]
ClinGenIFI6
Clinical trials, drugs, therapy
MyCancerGenomeIFI6
Protein Interactions : CTDIFI6
Pharm GKB GenePA28466
PharosP09912
Clinical trialIFI6
Miscellaneous
canSAR (ICR)IFI6
HarmonizomeIFI6
DataMed IndexIFI6
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIFI6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:21 CEST 2021

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