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IFIT1 (interferon induced protein with tetratricopeptide repeats 1)

Identity

Alias (NCBI)C56
G10P1
IFI-56
IFI-56K
IFI56
IFIT-1
IFNAI1
ISG56
P56
RNM561
HGNC (Hugo) IFIT1
HGNC Alias symbGARG-16
HGNC Previous nameG10P1
 IFI56
 IFNAI1
HGNC Previous nameinterferon-induced protein with tetratricopeptide repeats 1
LocusID (NCBI) 3434
Atlas_Id 52498
Location 10q23.31  [Link to chromosome band 10q23]
Location_base_pair Starts at 89392623 and ends at 89406487 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FYTTD1 (3q29) / IFIT1 (10q23.31)FYTTD1 3q29 / IFIT1 10q23.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IFIT1   5407
Cards
Entrez_Gene (NCBI)IFIT1    interferon induced protein with tetratricopeptide repeats 1
AliasesC56; G10P1; IFI-56; IFI-56K; 
IFI56; IFIT-1; IFNAI1; ISG56; P56; RNM561
GeneCards (Weizmann)IFIT1
Ensembl hg19 (Hinxton)ENSG00000185745 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185745 [Gene_View]  ENSG00000185745 [Sequence]  chr10:89392623-89406487 [Contig_View]  IFIT1 [Vega]
ICGC DataPortalENSG00000185745
TCGA cBioPortalIFIT1
AceView (NCBI)IFIT1
Genatlas (Paris)IFIT1
SOURCE (Princeton)IFIT1
Genetics Home Reference (NIH)IFIT1
Genomic and cartography
GoldenPath hg38 (UCSC)IFIT1  -     chr10:89392623-89406487 +  10q23.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFIT1  -     10q23.31   [Description]    (hg19-Feb_2009)
GoldenPathIFIT1 - 10q23.31 [CytoView hg19]  IFIT1 - 10q23.31 [CytoView hg38]
ImmunoBaseENSG00000185745
Genome Data Viewer NCBIIFIT1 [Mapview hg19]  
OMIM147690   
Gene and transcription
Genbank (Entrez)AK092813 AK308688 AK314588 AL548182 AL711085
RefSeq transcript (Entrez)NM_001270927 NM_001270928 NM_001270929 NM_001270930 NM_001548
Consensus coding sequences : CCDS (NCBI)IFIT1
Gene ExpressionIFIT1 [ NCBI-GEO ]   IFIT1 [ EBI - ARRAY_EXPRESS ]   IFIT1 [ SEEK ]   IFIT1 [ MEM ]
Gene Expression Viewer (FireBrowse)IFIT1 [ Firebrowse - Broad ]
GenevisibleExpression of IFIT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3434
GTEX Portal (Tissue expression)IFIT1
Human Protein AtlasENSG00000185745-IFIT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09914   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09914  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09914
PhosPhoSitePlusP09914
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Interferon-induced_IFIT1-like    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat   
Domain families : Pfam (Sanger)TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)IFIT1
PDB (RSDB)4HOU    5UDI    5UDJ    5UDK    5UDL    5W5H    5W5I    6C6K   
PDB Europe4HOU    5UDI    5UDJ    5UDK    5UDL    5W5H    5W5I    6C6K   
PDB (PDBSum)4HOU    5UDI    5UDJ    5UDK    5UDL    5W5H    5W5I    6C6K   
PDB (IMB)4HOU    5UDI    5UDJ    5UDK    5UDL    5W5H    5W5I    6C6K   
Structural Biology KnowledgeBase4HOU    5UDI    5UDJ    5UDK    5UDL    5W5H    5W5I    6C6K   
SCOP (Structural Classification of Proteins)4HOU    5UDI    5UDJ    5UDK    5UDL    5W5H    5W5I    6C6K   
CATH (Classification of proteins structures)4HOU    5UDI    5UDJ    5UDK    5UDL    5W5H    5W5I    6C6K   
SuperfamilyP09914
AlphaFold pdb e-kbP09914   
Human Protein Atlas [tissue]ENSG00000185745-IFIT1 [tissue]
HPRD00983
Protein Interaction databases
DIP (DOE-UCLA)P09914
IntAct (EBI)P09914
BioGRIDIFIT1
STRING (EMBL)IFIT1
ZODIACIFIT1
Ontologies - Pathways
QuickGOP09914
Ontology : AmiGORNA binding  RNA binding  protein binding  cytoplasm  cytosol  cytosol  cytosol  response to virus  response to virus  intracellular transport of viral protein in host cell  negative regulation of protein binding  host cell  positive regulation of viral genome replication  negative regulation of viral genome replication  regulation of defense response to virus  negative regulation of helicase activity  defense response to virus  type I interferon signaling pathway  cellular response to type I interferon  cellular response to exogenous dsRNA  antiviral innate immune response  
Ontology : EGO-EBIRNA binding  RNA binding  protein binding  cytoplasm  cytosol  cytosol  cytosol  response to virus  response to virus  intracellular transport of viral protein in host cell  negative regulation of protein binding  host cell  positive regulation of viral genome replication  negative regulation of viral genome replication  regulation of defense response to virus  negative regulation of helicase activity  defense response to virus  type I interferon signaling pathway  cellular response to type I interferon  cellular response to exogenous dsRNA  antiviral innate immune response  
Pathways : KEGGHepatitis C    Herpes simplex infection   
NDEx NetworkIFIT1
Atlas of Cancer Signalling NetworkIFIT1
Wikipedia pathwaysIFIT1
Orthology - Evolution
OrthoDB3434
GeneTree (enSembl)ENSG00000185745
Phylogenetic Trees/Animal Genes : TreeFamIFIT1
Homologs : HomoloGeneIFIT1
Homology/Alignments : Family Browser (UCSC)IFIT1
Gene fusions - Rearrangements
Fusion : MitelmanFYTTD1/IFIT1 [3q29/10q23.31]  
Fusion : QuiverIFIT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFIT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFIT1
dbVarIFIT1
ClinVarIFIT1
MonarchIFIT1
1000_GenomesIFIT1 
Exome Variant ServerIFIT1
GNOMAD BrowserENSG00000185745
Varsome BrowserIFIT1
ACMGIFIT1 variants
VarityP09914
Genomic Variants (DGV)IFIT1 [DGVbeta]
DECIPHERIFIT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFIT1 
Mutations
ICGC Data PortalIFIT1 
TCGA Data PortalIFIT1 
Broad Tumor PortalIFIT1
OASIS PortalIFIT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFIT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIFIT1
Mutations and Diseases : HGMDIFIT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIFIT1
DgiDB (Drug Gene Interaction Database)IFIT1
DoCM (Curated mutations)IFIT1
CIViC (Clinical Interpretations of Variants in Cancer)IFIT1
Cancer3DIFIT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147690   
Orphanet
DisGeNETIFIT1
MedgenIFIT1
Genetic Testing Registry IFIT1
NextProtP09914 [Medical]
GENETestsIFIT1
Target ValidationIFIT1
Huge Navigator IFIT1 [HugePedia]
ClinGenIFIT1
Clinical trials, drugs, therapy
MyCancerGenomeIFIT1
Protein Interactions : CTDIFIT1
Pharm GKB GenePA29648
PharosP09914
Clinical trialIFIT1
Miscellaneous
canSAR (ICR)IFIT1
HarmonizomeIFIT1
DataMed IndexIFIT1
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIFIT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:22 CEST 2021

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