IFIT3 (interferon induced protein with tetratricopeptide repeats 3)

2013-01-01  

Identity

HGNC
LOCATION
10q23.31
LOCUSID
ALIAS
CIG-49,GARG-49,IFI60,IFIT4,IRG2,ISG60,P60,RIG-G,cig41

Other Information

Locus ID:

NCBI: 3437
MIM: 604650
HGNC: 5411
Ensembl: ENSG00000119917

Variants:

dbSNP: 3437
ClinVar: 3437
TCGA: ENSG00000119917
COSMIC: IFIT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119917ENST00000371811O14879
ENSG00000119917ENST00000371811Q5T765
ENSG00000119917ENST00000371818O14879
ENSG00000119917ENST00000371818Q5T765

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
218137732011IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.55
193518182009IRF-9/STAT2 [corrected] functional interaction drives retinoic acid-induced gene G expression independently of STAT1.38
206860462010Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene.34
251313322015IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection.33
242239592013Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells.25
295543482018IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.14
272103122016Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a.12
276811382016Herpes Simplex Virus 1 Tegument Protein UL41 Counteracts IFIT3 Antiviral Innate Immunity.11
276016572016Influence of IFNL3 and HLA-DPB1 genotype on postpartum control of hepatitis C virus replication and T-cell recovery.10

Citation

Dessen P

IFIT3 (interferon induced protein with tetratricopeptide repeats 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53142/ifit3