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IFIT3 (interferon induced protein with tetratricopeptide repeats 3)

Identity

Alias_namesIFIT4
interferon-induced protein with tetratricopeptide repeats 4
interferon-induced protein with tetratricopeptide repeats 3
Alias_symbol (synonym)ISG60
RIG-G
CIG-49
IFI60
GARG-49
IRG2
Other aliasP60
cig41
HGNC (Hugo) IFIT3
LocusID (NCBI) 3437
Atlas_Id 53142
Location 10q23.31  [Link to chromosome band 10q23]
Location_base_pair Starts at 89327819 and ends at 89340968 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFIT3   5411
Cards
Entrez_Gene (NCBI)IFIT3  3437  interferon induced protein with tetratricopeptide repeats 3
AliasesCIG-49; GARG-49; IFI60; IFIT4; 
IRG2; ISG60; P60; RIG-G; cig41
GeneCards (Weizmann)IFIT3
Ensembl hg19 (Hinxton)ENSG00000119917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119917 [Gene_View]  ENSG00000119917 [Sequence]  chr10:89327819-89340968 [Contig_View]  IFIT3 [Vega]
ICGC DataPortalENSG00000119917
TCGA cBioPortalIFIT3
AceView (NCBI)IFIT3
Genatlas (Paris)IFIT3
WikiGenes3437
SOURCE (Princeton)IFIT3
Genetics Home Reference (NIH)IFIT3
Genomic and cartography
GoldenPath hg38 (UCSC)IFIT3  -     chr10:89327819-89340968 +  10q23.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFIT3  -     10q23.31   [Description]    (hg19-Feb_2009)
EnsemblIFIT3 - 10q23.31 [CytoView hg19]  IFIT3 - 10q23.31 [CytoView hg38]
Mapping of homologs : NCBIIFIT3 [Mapview hg19]  IFIT3 [Mapview hg38]
OMIM604650   
Gene and transcription
Genbank (Entrez)AF026939 AF026943 AF083470 AK290427 AK297137
RefSeq transcript (Entrez)NM_001031683 NM_001289758 NM_001289759 NM_001549
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFIT3
Cluster EST : UnigeneHs.744072 [ NCBI ]
CGAP (NCI)Hs.744072
Alternative Splicing GalleryENSG00000119917
Gene ExpressionIFIT3 [ NCBI-GEO ]   IFIT3 [ EBI - ARRAY_EXPRESS ]   IFIT3 [ SEEK ]   IFIT3 [ MEM ]
Gene Expression Viewer (FireBrowse)IFIT3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3437
GTEX Portal (Tissue expression)IFIT3
Human Protein AtlasENSG00000119917-IFIT3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14879   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14879  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14879
Splice isoforms : SwissVarO14879
PhosPhoSitePlusO14879
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Interferon-induced_IFIT3    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat   
Domain families : Pfam (Sanger)TPR_7 (PF13176)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam13176    pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)IFIT3
DMDM Disease mutations3437
Blocks (Seattle)IFIT3
SuperfamilyO14879
Human Protein Atlas [tissue]ENSG00000119917-IFIT3 [tissue]
Peptide AtlasO14879
HPRD05228
IPIIPI00024254   IPI01012599   
Protein Interaction databases
DIP (DOE-UCLA)O14879
IntAct (EBI)O14879
FunCoupENSG00000119917
BioGRIDIFIT3
STRING (EMBL)IFIT3
ZODIACIFIT3
Ontologies - Pathways
QuickGOO14879
Ontology : AmiGOmolecular_function  RNA binding  protein binding  protein binding  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  negative regulation of cell proliferation  response to virus  response to bacterium  cellular response to interferon-alpha  cellular response to interferon-beta  identical protein binding  negative regulation of apoptotic process  defense response to virus  type I interferon signaling pathway  
Ontology : EGO-EBImolecular_function  RNA binding  protein binding  protein binding  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  negative regulation of cell proliferation  response to virus  response to bacterium  cellular response to interferon-alpha  cellular response to interferon-beta  identical protein binding  negative regulation of apoptotic process  defense response to virus  type I interferon signaling pathway  
NDEx NetworkIFIT3
Atlas of Cancer Signalling NetworkIFIT3
Wikipedia pathwaysIFIT3
Orthology - Evolution
OrthoDB3437
GeneTree (enSembl)ENSG00000119917
Phylogenetic Trees/Animal Genes : TreeFamIFIT3
HOVERGENO14879
HOGENOMO14879
Homologs : HomoloGeneIFIT3
Homology/Alignments : Family Browser (UCSC)IFIT3
Gene fusions - Rearrangements
Fusion : QuiverIFIT3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFIT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFIT3
dbVarIFIT3
ClinVarIFIT3
1000_GenomesIFIT3 
Exome Variant ServerIFIT3
ExAC (Exome Aggregation Consortium)ENSG00000119917
GNOMAD BrowserENSG00000119917
Varsome BrowserIFIT3
Genetic variants : HAPMAP3437
Genomic Variants (DGV)IFIT3 [DGVbeta]
DECIPHERIFIT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFIT3 
Mutations
ICGC Data PortalIFIT3 
TCGA Data PortalIFIT3 
Broad Tumor PortalIFIT3
OASIS PortalIFIT3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFIT3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIFIT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IFIT3
DgiDB (Drug Gene Interaction Database)IFIT3
DoCM (Curated mutations)IFIT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFIT3 (select a term)
intoGenIFIT3
Cancer3DIFIT3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604650   
Orphanet
DisGeNETIFIT3
MedgenIFIT3
Genetic Testing Registry IFIT3
NextProtO14879 [Medical]
TSGene3437
GENETestsIFIT3
Target ValidationIFIT3
Huge Navigator IFIT3 [HugePedia]
snp3D : Map Gene to Disease3437
BioCentury BCIQIFIT3
ClinGenIFIT3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3437
Chemical/Pharm GKB GenePA29651
Clinical trialIFIT3
Miscellaneous
canSAR (ICR)IFIT3 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFIT3
EVEXIFIT3
GoPubMedIFIT3
iHOPIFIT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:12:36 CET 2018

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