IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2)

2007-02-01  

Identity

HGNC
LOCATION
3q27.2
LOCUSID
ALIAS
IMP-2,IMP2,VICKZ2
FUSION GENES

Other Information

Locus ID:

NCBI: 10644
MIM: 608289
HGNC: 28867
Ensembl: ENSG00000073792

Variants:

dbSNP: 10644
ClinVar: 10644
TCGA: ENSG00000073792
COSMIC: IGF2BP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073792ENST00000346192Q9Y6M1
ENSG00000073792ENST00000382199Q9Y6M1
ENSG00000073792ENST00000421047Q9Y6M1
ENSG00000073792ENST00000457616F8W930

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNAREACTOMER-HSA-428359

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443890Diabetes Mellitus, Type 2DiseaseClinicalAnnotationassociatedPD
PA451234repaglinideChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
174632462007Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.1137
174632482007A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.1102
174632492007Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.887
190203232008Genotype score in addition to common risk factors for prediction of type 2 diabetes.304
190203242008Clinical risk factors, DNA variants, and the development of type 2 diabetes.262
294761522018Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.144
228990102012Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.130
185913882008Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.129
184692042008Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.128
184692042008Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.128

Citation

Dessen P

IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46232/igf2bp2