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IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2)

Identity

Alias_namesinsulin-like growth factor 2 mRNA binding protein 2
Alias_symbol (synonym)IMP-2
Other aliasIMP2
VICKZ2
HGNC (Hugo) IGF2BP2
LocusID (NCBI) 10644
Atlas_Id 46232
Location 3q27.2  [Link to chromosome band 3q27]
Location_base_pair Starts at 185643131 and ends at 185825056 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACTN4 (19q13.2) / IGF2BP2 (3q27.2)IGF2BP2 (3q27.2) / IGF2BP2 (3q27.2)IGF2BP2 (3q27.2) / NCEH1 (3q26.31)
IGF2BP2 (3q27.2) / RASSF6 (4q13.3)TSC22D1 (13q14.11) / IGF2BP2 (3q27.2)IGF2BP2 3q27.2 / NCEH1 3q26.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)IGF2BP2   28867
Cards
Entrez_Gene (NCBI)IGF2BP2  10644  insulin like growth factor 2 mRNA binding protein 2
AliasesIMP-2; IMP2; VICKZ2
GeneCards (Weizmann)IGF2BP2
Ensembl hg19 (Hinxton)ENSG00000073792 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073792 [Gene_View]  chr3:185643131-185825056 [Contig_View]  IGF2BP2 [Vega]
ICGC DataPortalENSG00000073792
TCGA cBioPortalIGF2BP2
AceView (NCBI)IGF2BP2
Genatlas (Paris)IGF2BP2
WikiGenes10644
SOURCE (Princeton)IGF2BP2
Genetics Home Reference (NIH)IGF2BP2
Genomic and cartography
GoldenPath hg38 (UCSC)IGF2BP2  -     chr3:185643131-185825056 -  3q27.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGF2BP2  -     3q27.2   [Description]    (hg19-Feb_2009)
EnsemblIGF2BP2 - 3q27.2 [CytoView hg19]  IGF2BP2 - 3q27.2 [CytoView hg38]
Mapping of homologs : NCBIIGF2BP2 [Mapview hg19]  IGF2BP2 [Mapview hg38]
OMIM125853   608289   
Gene and transcription
Genbank (Entrez)AA451676 AF117107 AI336648 AI348863 AK290664
RefSeq transcript (Entrez)NM_001007225 NM_001291869 NM_001291872 NM_001291873 NM_001291874 NM_001291875 NM_006548
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGF2BP2
Cluster EST : UnigeneHs.293396 [ NCBI ]
CGAP (NCI)Hs.293396
Alternative Splicing GalleryENSG00000073792
Gene ExpressionIGF2BP2 [ NCBI-GEO ]   IGF2BP2 [ EBI - ARRAY_EXPRESS ]   IGF2BP2 [ SEEK ]   IGF2BP2 [ MEM ]
Gene Expression Viewer (FireBrowse)IGF2BP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10644
GTEX Portal (Tissue expression)IGF2BP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6M1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6M1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6M1
Splice isoforms : SwissVarQ9Y6M1
PhosPhoSitePlusQ9Y6M1
Domaine pattern : Prosite (Expaxy)KH_TYPE_1 (PS50084)    RRM (PS50102)   
Domains : Interpro (EBI)IGF2BP2    KH_dom    KH_dom_type_1    Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)KH_1 (PF00013)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00013    pfam00076   
Domain families : Smart (EMBL)KH (SM00322)  RRM (SM00360)  
Conserved Domain (NCBI)IGF2BP2
DMDM Disease mutations10644
Blocks (Seattle)IGF2BP2
PDB (SRS)2CQH   
PDB (PDBSum)2CQH   
PDB (IMB)2CQH   
PDB (RSDB)2CQH   
Structural Biology KnowledgeBase2CQH   
SCOP (Structural Classification of Proteins)2CQH   
CATH (Classification of proteins structures)2CQH   
SuperfamilyQ9Y6M1
Human Protein AtlasENSG00000073792
Peptide AtlasQ9Y6M1
HPRD10507
IPIIPI00180983   IPI00179713   IPI00743914   IPI00922068   IPI00953576   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6M1
IntAct (EBI)Q9Y6M1
FunCoupENSG00000073792
BioGRIDIGF2BP2
STRING (EMBL)IGF2BP2
ZODIACIGF2BP2
Ontologies - Pathways
QuickGOQ9Y6M1
Ontology : AmiGORNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  cytoskeleton  anatomical structure morphogenesis  gene expression  negative regulation of translation  regulation of cytokine biosynthetic process  translation regulator activity  mRNA 5'-UTR binding  mRNA transport  
Ontology : EGO-EBIRNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  cytoskeleton  anatomical structure morphogenesis  gene expression  negative regulation of translation  regulation of cytokine biosynthetic process  translation regulator activity  mRNA 5'-UTR binding  mRNA transport  
NDEx NetworkIGF2BP2
Atlas of Cancer Signalling NetworkIGF2BP2
Wikipedia pathwaysIGF2BP2
Orthology - Evolution
OrthoDB10644
GeneTree (enSembl)ENSG00000073792
Phylogenetic Trees/Animal Genes : TreeFamIGF2BP2
HOVERGENQ9Y6M1
HOGENOMQ9Y6M1
Homologs : HomoloGeneIGF2BP2
Homology/Alignments : Family Browser (UCSC)IGF2BP2
Gene fusions - Rearrangements
Fusion : MitelmanACTN4/IGF2BP2 [19q13.2/3q27.2]  [t(3;19)(q27;q13)]  
Fusion : MitelmanIGF2BP2/NCEH1 [3q27.2/3q26.31]  [t(3;3)(q26;q27)]  
Fusion: TCGAIGF2BP2 3q27.2 NCEH1 3q26.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGF2BP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGF2BP2
dbVarIGF2BP2
ClinVarIGF2BP2
1000_GenomesIGF2BP2 
Exome Variant ServerIGF2BP2
ExAC (Exome Aggregation Consortium)IGF2BP2 (select the gene name)
Genetic variants : HAPMAP10644
Genomic Variants (DGV)IGF2BP2 [DGVbeta]
DECIPHERIGF2BP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGF2BP2 
Mutations
ICGC Data PortalIGF2BP2 
TCGA Data PortalIGF2BP2 
Broad Tumor PortalIGF2BP2
OASIS PortalIGF2BP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGF2BP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGF2BP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch IGF2BP2
DgiDB (Drug Gene Interaction Database)IGF2BP2
DoCM (Curated mutations)IGF2BP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGF2BP2 (select a term)
intoGenIGF2BP2
Cancer3DIGF2BP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125853    608289   
Orphanet
MedgenIGF2BP2
Genetic Testing Registry IGF2BP2
NextProtQ9Y6M1 [Medical]
TSGene10644
GENETestsIGF2BP2
Target ValidationIGF2BP2
Huge Navigator IGF2BP2 [HugePedia]
snp3D : Map Gene to Disease10644
BioCentury BCIQIGF2BP2
ClinGenIGF2BP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10644
Chemical/Pharm GKB GenePA128394577
Clinical trialIGF2BP2
Miscellaneous
canSAR (ICR)IGF2BP2 (select the gene name)
Probes
Litterature
PubMed168 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGF2BP2
EVEXIGF2BP2
GoPubMedIGF2BP2
iHOPIGF2BP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:38:06 CEST 2017

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