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IGFALS (insulin like growth factor binding protein acid labile subunit)

Identity

Alias_namesinsulin-like growth factor binding protein
Alias_symbol (synonym)ALS
Other aliasACLSD
HGNC (Hugo) IGFALS
LocusID (NCBI) 3483
Atlas_Id 49824
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1790413 and ends at 1793733 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IGFALS   5468
Cards
Entrez_Gene (NCBI)IGFALS  3483  insulin like growth factor binding protein acid labile subunit
AliasesACLSD; ALS
GeneCards (Weizmann)IGFALS
Ensembl hg19 (Hinxton)ENSG00000099769 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099769 [Gene_View]  chr16:1790413-1793733 [Contig_View]  IGFALS [Vega]
ICGC DataPortalENSG00000099769
TCGA cBioPortalIGFALS
AceView (NCBI)IGFALS
Genatlas (Paris)IGFALS
WikiGenes3483
SOURCE (Princeton)IGFALS
Genetics Home Reference (NIH)IGFALS
Genomic and cartography
GoldenPath hg38 (UCSC)IGFALS  -     chr16:1790413-1793733 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGFALS  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblIGFALS - 16p13.3 [CytoView hg19]  IGFALS - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIIGFALS [Mapview hg19]  IGFALS [Mapview hg38]
OMIM601489   615961   
Gene and transcription
Genbank (Entrez)AK292182 AK303146 AK309598 AK313198 AK315808
RefSeq transcript (Entrez)NM_001146006 NM_004970
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGFALS
Cluster EST : UnigeneHs.839 [ NCBI ]
CGAP (NCI)Hs.839
Alternative Splicing GalleryENSG00000099769
Gene ExpressionIGFALS [ NCBI-GEO ]   IGFALS [ EBI - ARRAY_EXPRESS ]   IGFALS [ SEEK ]   IGFALS [ MEM ]
Gene Expression Viewer (FireBrowse)IGFALS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3483
GTEX Portal (Tissue expression)IGFALS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35858   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35858  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35858
Splice isoforms : SwissVarP35858
PhosPhoSitePlusP35858
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRRNT   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    LRRNT (PF01462)   
Domain families : Pfam (NCBI)pfam13855    pfam01462   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
Conserved Domain (NCBI)IGFALS
DMDM Disease mutations3483
Blocks (Seattle)IGFALS
SuperfamilyP35858
Human Protein AtlasENSG00000099769
Peptide AtlasP35858
HPRD03290
IPIIPI00020996   IPI00925635   
Protein Interaction databases
DIP (DOE-UCLA)P35858
IntAct (EBI)P35858
FunCoupENSG00000099769
BioGRIDIGFALS
STRING (EMBL)IGFALS
ZODIACIGFALS
Ontologies - Pathways
QuickGOP35858
Ontology : AmiGOinsulin-like growth factor binding  extracellular region  extracellular region  extracellular space  nucleoplasm  cell adhesion  signal transduction  insulin-like growth factor ternary complex  cellular protein metabolic process  extracellular exosome  
Ontology : EGO-EBIinsulin-like growth factor binding  extracellular region  extracellular region  extracellular space  nucleoplasm  cell adhesion  signal transduction  insulin-like growth factor ternary complex  cellular protein metabolic process  extracellular exosome  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]   
NDEx NetworkIGFALS
Atlas of Cancer Signalling NetworkIGFALS
Wikipedia pathwaysIGFALS
Orthology - Evolution
OrthoDB3483
GeneTree (enSembl)ENSG00000099769
Phylogenetic Trees/Animal Genes : TreeFamIGFALS
HOVERGENP35858
HOGENOMP35858
Homologs : HomoloGeneIGFALS
Homology/Alignments : Family Browser (UCSC)IGFALS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGFALS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFALS
dbVarIGFALS
ClinVarIGFALS
1000_GenomesIGFALS 
Exome Variant ServerIGFALS
ExAC (Exome Aggregation Consortium)IGFALS (select the gene name)
Genetic variants : HAPMAP3483
Genomic Variants (DGV)IGFALS [DGVbeta]
DECIPHERIGFALS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGFALS 
Mutations
ICGC Data PortalIGFALS 
TCGA Data PortalIGFALS 
Broad Tumor PortalIGFALS
OASIS PortalIGFALS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFALS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGFALS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch IGFALS
DgiDB (Drug Gene Interaction Database)IGFALS
DoCM (Curated mutations)IGFALS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGFALS (select a term)
intoGenIGFALS
Cancer3DIGFALS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601489    615961   
Orphanet17003   
MedgenIGFALS
Genetic Testing Registry IGFALS
NextProtP35858 [Medical]
TSGene3483
GENETestsIGFALS
Target ValidationIGFALS
Huge Navigator IGFALS [HugePedia]
snp3D : Map Gene to Disease3483
BioCentury BCIQIGFALS
ClinGenIGFALS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3483
Chemical/Pharm GKB GenePA29702
Clinical trialIGFALS
Miscellaneous
canSAR (ICR)IGFALS (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGFALS
EVEXIGFALS
GoPubMedIGFALS
iHOPIGFALS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:38:07 CEST 2017

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