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IGFBP3 (insulin like growth factor binding protein 3)

Identity

Alias_namesinsulin-like growth factor binding protein 3
Alias_symbol (synonym)IBP3
BP-53
Other alias
HGNC (Hugo) IGFBP3
LocusID (NCBI) 3486
Atlas_Id 40932
Location 7p12.3  [Link to chromosome band 7p12]
Location_base_pair Starts at 45912245 and ends at 45921272 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANTXR2 (4q21.21) / IGFBP3 (7p12.3)CD47 (3q13.12) / IGFBP3 (7p12.3)GSK3A (19q13.2) / IGFBP3 (7p12.3)
IGFBP3 (7p12.3) / ANTXR2 (4q21.21)IGFBP3 (7p12.3) / DPP7 (9q34.3)IGFBP3 (7p12.3) / IGFBP3 (7p12.3)
IGFBP3 (7p12.3) / MAMDC2 (9q21.12)IGFBP3 (7p12.3) / SLC2A3 (12p13.31)MZT2B (2q21.1) / IGFBP3 (7p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)IGFBP3   5472
LRG (Locus Reference Genomic)LRG_68
Cards
Entrez_Gene (NCBI)IGFBP3  3486  insulin like growth factor binding protein 3
AliasesBP-53; IBP3
GeneCards (Weizmann)IGFBP3
Ensembl hg19 (Hinxton)ENSG00000146674 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146674 [Gene_View]  chr7:45912245-45921272 [Contig_View]  IGFBP3 [Vega]
ICGC DataPortalENSG00000146674
TCGA cBioPortalIGFBP3
AceView (NCBI)IGFBP3
Genatlas (Paris)IGFBP3
WikiGenes3486
SOURCE (Princeton)IGFBP3
Genetics Home Reference (NIH)IGFBP3
Genomic and cartography
GoldenPath hg38 (UCSC)IGFBP3  -     chr7:45912245-45921272 -  7p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGFBP3  -     7p12.3   [Description]    (hg19-Feb_2009)
EnsemblIGFBP3 - 7p12.3 [CytoView hg19]  IGFBP3 - 7p12.3 [CytoView hg38]
Mapping of homologs : NCBIIGFBP3 [Mapview hg19]  IGFBP3 [Mapview hg38]
OMIM146732   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_000598 NM_001013398
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGFBP3
Cluster EST : UnigeneHs.450230 [ NCBI ]
CGAP (NCI)Hs.450230
Alternative Splicing GalleryENSG00000146674
Gene ExpressionIGFBP3 [ NCBI-GEO ]   IGFBP3 [ EBI - ARRAY_EXPRESS ]   IGFBP3 [ SEEK ]   IGFBP3 [ MEM ]
Gene Expression Viewer (FireBrowse)IGFBP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3486
GTEX Portal (Tissue expression)IGFBP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17936   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17936  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17936
Splice isoforms : SwissVarP17936
PhosPhoSitePlusP17936
Domaine pattern : Prosite (Expaxy)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)Growth_fac_rcpt_    IGFBP-3    IGFBP-like    IGFBP1-6    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00219    pfam00086   
Domain families : Smart (EMBL)IB (SM00121)  TY (SM00211)  
Conserved Domain (NCBI)IGFBP3
DMDM Disease mutations3486
Blocks (Seattle)IGFBP3
SuperfamilyP17936
Human Protein AtlasENSG00000146674
Peptide AtlasP17936
HPRD00899
IPIIPI00018305   IPI00925358   IPI00924814   IPI00902471   IPI01013803   IPI00903293   IPI00444386   IPI00435925   IPI00926261   IPI00556155   
Protein Interaction databases
DIP (DOE-UCLA)P17936
IntAct (EBI)P17936
FunCoupENSG00000146674
BioGRIDIGFBP3
STRING (EMBL)IGFBP3
ZODIACIGFBP3
Ontologies - Pathways
QuickGOP17936
Ontology : AmiGOregulation of cell growth  osteoblast differentiation  negative regulation of protein phosphorylation  fibronectin binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular region  extracellular space  nucleus  protein phosphorylation  apoptotic process  protein tyrosine phosphatase activator activity  negative regulation of cell proliferation  negative regulation of signal transduction  regulation of glucose metabolic process  negative regulation of smooth muscle cell migration  insulin-like growth factor binding protein complex  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor ternary complex  regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of catalytic activity  positive regulation of MAPK cascade  regulation of insulin-like growth factor receptor signaling pathway  positive regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  type B pancreatic cell proliferation  positive regulation of myoblast differentiation  metal ion binding  negative regulation of smooth muscle cell proliferation  extracellular exosome  
Ontology : EGO-EBIregulation of cell growth  osteoblast differentiation  negative regulation of protein phosphorylation  fibronectin binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular region  extracellular space  nucleus  protein phosphorylation  apoptotic process  protein tyrosine phosphatase activator activity  negative regulation of cell proliferation  negative regulation of signal transduction  regulation of glucose metabolic process  negative regulation of smooth muscle cell migration  insulin-like growth factor binding protein complex  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor ternary complex  regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of catalytic activity  positive regulation of MAPK cascade  regulation of insulin-like growth factor receptor signaling pathway  positive regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  type B pancreatic cell proliferation  positive regulation of myoblast differentiation  metal ion binding  negative regulation of smooth muscle cell proliferation  extracellular exosome  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]    Hypoxia and p53 in the Cardiovascular system [Genes]   
Pathways : KEGGp53 signaling pathway    Transcriptional misregulation in cancer   
NDEx NetworkIGFBP3
Atlas of Cancer Signalling NetworkIGFBP3
Wikipedia pathwaysIGFBP3
Orthology - Evolution
OrthoDB3486
GeneTree (enSembl)ENSG00000146674
Phylogenetic Trees/Animal Genes : TreeFamIGFBP3
HOVERGENP17936
HOGENOMP17936
Homologs : HomoloGeneIGFBP3
Homology/Alignments : Family Browser (UCSC)IGFBP3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGFBP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFBP3
dbVarIGFBP3
ClinVarIGFBP3
1000_GenomesIGFBP3 
Exome Variant ServerIGFBP3
ExAC (Exome Aggregation Consortium)IGFBP3 (select the gene name)
Genetic variants : HAPMAP3486
Genomic Variants (DGV)IGFBP3 [DGVbeta]
DECIPHERIGFBP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGFBP3 
Mutations
ICGC Data PortalIGFBP3 
TCGA Data PortalIGFBP3 
Broad Tumor PortalIGFBP3
OASIS PortalIGFBP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFBP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGFBP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IGFBP3
DgiDB (Drug Gene Interaction Database)IGFBP3
DoCM (Curated mutations)IGFBP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGFBP3 (select a term)
intoGenIGFBP3
Cancer3DIGFBP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146732   
Orphanet
MedgenIGFBP3
Genetic Testing Registry IGFBP3
NextProtP17936 [Medical]
TSGene3486
GENETestsIGFBP3
Target ValidationIGFBP3
Huge Navigator IGFBP3 [HugePedia]
snp3D : Map Gene to Disease3486
BioCentury BCIQIGFBP3
ClinGenIGFBP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3486
Chemical/Pharm GKB GenePA29705
Clinical trialIGFBP3
Miscellaneous
canSAR (ICR)IGFBP3 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGFBP3
EVEXIGFBP3
GoPubMedIGFBP3
iHOPIGFBP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:38:08 CEST 2017

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