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IGFBP3 (insulin like growth factor binding protein 3)

Identity

Alias (NCBI)BP-53
IBP3
HGNC (Hugo) IGFBP3
HGNC Alias symbIBP3
BP-53
HGNC Alias namegrowth hormone-dependent binding protein
 acid stable subunit of the 140 K IGF complex
 binding protein 53
 binding protein 29
 IGF-binding protein 3
HGNC Previous nameinsulin-like growth factor binding protein 3
LocusID (NCBI) 3486
Atlas_Id 40932
Location 7p12.3  [Link to chromosome band 7p12]
Location_base_pair Starts at 45912245 and ends at 45921272 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANTXR2 (4q21.21) / IGFBP3 (7p12.3)CD47 (3q13.12) / IGFBP3 (7p12.3)GSK3A (19q13.2) / IGFBP3 (7p12.3)
IGFBP3 (7p12.3) / ANTXR2 (4q21.21)IGFBP3 (7p12.3) / DPP7 (9q34.3)IGFBP3 (7p12.3) / IGFBP3 (7p12.3)
IGFBP3 (7p12.3) / MAMDC2 (9q21.12)IGFBP3 (7p12.3) / SLC2A3 (12p13.31)MZT2B (2q21.1) / IGFBP3 (7p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IGFBP3   5472
LRG (Locus Reference Genomic)LRG_68
Cards
Entrez_Gene (NCBI)IGFBP3    insulin like growth factor binding protein 3
AliasesBP-53; IBP3
GeneCards (Weizmann)IGFBP3
Ensembl hg19 (Hinxton)ENSG00000146674 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146674 [Gene_View]  ENSG00000146674 [Sequence]  chr7:45912245-45921272 [Contig_View]  IGFBP3 [Vega]
ICGC DataPortalENSG00000146674
TCGA cBioPortalIGFBP3
AceView (NCBI)IGFBP3
Genatlas (Paris)IGFBP3
SOURCE (Princeton)IGFBP3
Genetics Home Reference (NIH)IGFBP3
Genomic and cartography
GoldenPath hg38 (UCSC)IGFBP3  -     chr7:45912245-45921272 -  7p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGFBP3  -     7p12.3   [Description]    (hg19-Feb_2009)
GoldenPathIGFBP3 - 7p12.3 [CytoView hg19]  IGFBP3 - 7p12.3 [CytoView hg38]
ImmunoBaseENSG00000146674
Genome Data Viewer NCBIIGFBP3 [Mapview hg19]  
OMIM146732   
Gene and transcription
Genbank (Entrez)AF370418 AI142967 AK055632 AK056274 AK075483
RefSeq transcript (Entrez)NM_000598 NM_001013398
Consensus coding sequences : CCDS (NCBI)IGFBP3
Gene ExpressionIGFBP3 [ NCBI-GEO ]   IGFBP3 [ EBI - ARRAY_EXPRESS ]   IGFBP3 [ SEEK ]   IGFBP3 [ MEM ]
Gene Expression Viewer (FireBrowse)IGFBP3 [ Firebrowse - Broad ]
GenevisibleExpression of IGFBP3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3486
GTEX Portal (Tissue expression)IGFBP3
Human Protein AtlasENSG00000146674-IGFBP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17936   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17936  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17936
PhosPhoSitePlusP17936
Domaine pattern : Prosite (Expaxy)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)Growth_fac_rcpt_cys_sf    IGFBP-3    IGFBP-like    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1    Thyroglobulin_1_sf   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00219    pfam00086   
Domain families : Smart (EMBL)IB (SM00121)  TY (SM00211)  
Conserved Domain (NCBI)IGFBP3
SuperfamilyP17936
AlphaFold pdb e-kbP17936   
Human Protein Atlas [tissue]ENSG00000146674-IGFBP3 [tissue]
HPRD00899
Protein Interaction databases
DIP (DOE-UCLA)P17936
IntAct (EBI)P17936
BioGRIDIGFBP3
STRING (EMBL)IGFBP3
ZODIACIGFBP3
Ontologies - Pathways
QuickGOP17936
Ontology : AmiGOnegative regulation of protein phosphorylation  fibronectin binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular region  extracellular space  extracellular space  nucleus  endoplasmic reticulum lumen  protein phosphorylation  apoptotic process  protein tyrosine phosphatase activator activity  negative regulation of cell population proliferation  negative regulation of signal transduction  negative regulation of smooth muscle cell migration  insulin-like growth factor binding protein complex  insulin-like growth factor I binding  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor ternary complex  regulation of apoptotic process  positive regulation of apoptotic process  regulation of insulin-like growth factor receptor signaling pathway  post-translational protein modification  cellular protein metabolic process  positive regulation of myoblast differentiation  metal ion binding  negative regulation of smooth muscle cell proliferation  regulation of catalytic activity  
Ontology : EGO-EBInegative regulation of protein phosphorylation  fibronectin binding  protein binding  insulin-like growth factor binding  extracellular region  extracellular region  extracellular space  extracellular space  nucleus  endoplasmic reticulum lumen  protein phosphorylation  apoptotic process  protein tyrosine phosphatase activator activity  negative regulation of cell population proliferation  negative regulation of signal transduction  negative regulation of smooth muscle cell migration  insulin-like growth factor binding protein complex  insulin-like growth factor I binding  insulin-like growth factor I binding  insulin-like growth factor II binding  insulin-like growth factor ternary complex  regulation of apoptotic process  positive regulation of apoptotic process  regulation of insulin-like growth factor receptor signaling pathway  post-translational protein modification  cellular protein metabolic process  positive regulation of myoblast differentiation  metal ion binding  negative regulation of smooth muscle cell proliferation  regulation of catalytic activity  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]    Hypoxia and p53 in the Cardiovascular system [Genes]   
Pathways : KEGGp53 signaling pathway    Transcriptional misregulation in cancer   
NDEx NetworkIGFBP3
Atlas of Cancer Signalling NetworkIGFBP3
Wikipedia pathwaysIGFBP3
Orthology - Evolution
OrthoDB3486
GeneTree (enSembl)ENSG00000146674
Phylogenetic Trees/Animal Genes : TreeFamIGFBP3
Homologs : HomoloGeneIGFBP3
Homology/Alignments : Family Browser (UCSC)IGFBP3
Gene fusions - Rearrangements
Fusion : QuiverIGFBP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGFBP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFBP3
dbVarIGFBP3
ClinVarIGFBP3
MonarchIGFBP3
1000_GenomesIGFBP3 
Exome Variant ServerIGFBP3
GNOMAD BrowserENSG00000146674
Varsome BrowserIGFBP3
ACMGIGFBP3 variants
VarityP17936
Genomic Variants (DGV)IGFBP3 [DGVbeta]
DECIPHERIGFBP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGFBP3 
Mutations
ICGC Data PortalIGFBP3 
TCGA Data PortalIGFBP3 
Broad Tumor PortalIGFBP3
OASIS PortalIGFBP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFBP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIGFBP3
Mutations and Diseases : HGMDIGFBP3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIGFBP3
DgiDB (Drug Gene Interaction Database)IGFBP3
DoCM (Curated mutations)IGFBP3
CIViC (Clinical Interpretations of Variants in Cancer)IGFBP3
Cancer3DIGFBP3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146732   
Orphanet
DisGeNETIGFBP3
MedgenIGFBP3
Genetic Testing Registry IGFBP3
NextProtP17936 [Medical]
GENETestsIGFBP3
Target ValidationIGFBP3
Huge Navigator IGFBP3 [HugePedia]
ClinGenIGFBP3
Clinical trials, drugs, therapy
MyCancerGenomeIGFBP3
Protein Interactions : CTDIGFBP3
Pharm GKB GenePA29705
Pharm GKB PathwaysPA152241951   
PharosP17936
Clinical trialIGFBP3
Miscellaneous
canSAR (ICR)IGFBP3
HarmonizomeIGFBP3
DataMed IndexIGFBP3
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIGFBP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:13:33 CEST 2021

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