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IGFBP5 (insulin like growth factor binding protein 5)

Identity

Alias_namesinsulin-like growth factor binding protein 5
Other aliasIBP5
HGNC (Hugo) IGFBP5
LocusID (NCBI) 3488
Atlas_Id 45717
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 216672105 and ends at 216695549 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACSBG2 (19p13.3) / IGFBP5 (2q35)ALDH1A2 (15q21.3) / IGFBP5 (2q35)BNC2 (9p22.3) / IGFBP5 (2q35)
EZH1 (17q21.2) / IGFBP5 (2q35)GOLGA3 (12q24.33) / IGFBP5 (2q35)IGFBP5 (2q35) / ARHGEF10L (1p36.13)
IGFBP5 (2q35) / ARHGEF4 (2q21.1)IGFBP5 (2q35) / CXCR5 (11q23.3)IGFBP5 (2q35) / DDT (22q11.23)
IGFBP5 (2q35) / IGFBP5 (2q35)IGFBP5 (2q35) / PRC1 (15q26.1)IGFBP5 (2q35) / RALGAPA2 (20p11.23)
IGFBP5 (2q35) / RPL35 (9q33.3)IGFBP5 (2q35) / SIAE (11q24.2)IGFBP5 (2q35) / YAF2 (12q12)
KHSRP (19p13.3) / IGFBP5 (2q35)NASP (1p34.1) / IGFBP5 (2q35)RNF167 (17p13.2) / IGFBP5 (2q35)
RPL36 (19p13.3) / IGFBP5 (2q35)SAMD4A (14q22.2) / IGFBP5 (2q35)EZH1 17q21.2 / IGFBP5 2q35
IGFBP5 2q35 / ARHGEF4 2q21.1IGFBP5 2q35 / CXCR5 11q23.3IGFBP5 2q35 / SIAE 11q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IGFBP5   5474
Cards
Entrez_Gene (NCBI)IGFBP5  3488  insulin like growth factor binding protein 5
AliasesIBP5
GeneCards (Weizmann)IGFBP5
Ensembl hg19 (Hinxton)ENSG00000115461 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115461 [Gene_View]  chr2:216672105-216695549 [Contig_View]  IGFBP5 [Vega]
ICGC DataPortalENSG00000115461
TCGA cBioPortalIGFBP5
AceView (NCBI)IGFBP5
Genatlas (Paris)IGFBP5
WikiGenes3488
SOURCE (Princeton)IGFBP5
Genetics Home Reference (NIH)IGFBP5
Genomic and cartography
GoldenPath hg38 (UCSC)IGFBP5  -     chr2:216672105-216695549 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IGFBP5  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblIGFBP5 - 2q35 [CytoView hg19]  IGFBP5 - 2q35 [CytoView hg38]
Mapping of homologs : NCBIIGFBP5 [Mapview hg19]  IGFBP5 [Mapview hg38]
OMIM146734   
Gene and transcription
Genbank (Entrez)AF055033 AF147308 AK314992 AU132181 AV710460
RefSeq transcript (Entrez)NM_000599
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IGFBP5
Cluster EST : UnigeneHs.607212 [ NCBI ]
CGAP (NCI)Hs.607212
Alternative Splicing GalleryENSG00000115461
Gene ExpressionIGFBP5 [ NCBI-GEO ]   IGFBP5 [ EBI - ARRAY_EXPRESS ]   IGFBP5 [ SEEK ]   IGFBP5 [ MEM ]
Gene Expression Viewer (FireBrowse)IGFBP5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3488
GTEX Portal (Tissue expression)IGFBP5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24593   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24593  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24593
Splice isoforms : SwissVarP24593
PhosPhoSitePlusP24593
Domaine pattern : Prosite (Expaxy)IGFBP_N_1 (PS00222)    IGFBP_N_2 (PS51323)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)Growth_fac_rcpt_    IGFBP-5    IGFBP-like    IGFBP1-6    IGFBP_1-6_chordata    Insulin_GF-bd_Cys-rich_CS    Thyroglobulin_1   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00219    pfam00086   
Domain families : Smart (EMBL)IB (SM00121)  TY (SM00211)  
Conserved Domain (NCBI)IGFBP5
DMDM Disease mutations3488
Blocks (Seattle)IGFBP5
PDB (SRS)1BOE    1H59   
PDB (PDBSum)1BOE    1H59   
PDB (IMB)1BOE    1H59   
PDB (RSDB)1BOE    1H59   
Structural Biology KnowledgeBase1BOE    1H59   
SCOP (Structural Classification of Proteins)1BOE    1H59   
CATH (Classification of proteins structures)1BOE    1H59   
SuperfamilyP24593
Human Protein AtlasENSG00000115461
Peptide AtlasP24593
HPRD00901
IPIIPI00029236   IPI00816087   IPI00816014   IPI00924537   
Protein Interaction databases
DIP (DOE-UCLA)P24593
IntAct (EBI)P24593
FunCoupENSG00000115461
BioGRIDIGFBP5
STRING (EMBL)IGFBP5
ZODIACIGFBP5
Ontologies - Pathways
QuickGOP24593
Ontology : AmiGOregulation of cell growth  osteoblast differentiation  fibronectin binding  protein binding  extracellular region  extracellular region  intracellular  glucose metabolic process  signal transduction  female pregnancy  aging  regulation of glucose metabolic process  negative regulation of smooth muscle cell migration  insulin-like growth factor binding protein complex  negative regulation of translation  negative regulation of cell migration  hair follicle morphogenesis  insulin-like growth factor I binding  insulin-like growth factor II binding  intracellular signal transduction  insulin-like growth factor ternary complex  glucose homeostasis  positive regulation of insulin-like growth factor receptor signaling pathway  negative regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  type B pancreatic cell proliferation  negative regulation of osteoblast differentiation  negative regulation of growth  lung alveolus development  negative regulation of smooth muscle cell proliferation  striated muscle cell differentiation  positive regulation of protein kinase B signaling  mammary gland involution  response to growth hormone  cellular response to cAMP  cellular response to organic cyclic compound  negative regulation of muscle tissue development  negative regulation of skeletal muscle hypertrophy  
Ontology : EGO-EBIregulation of cell growth  osteoblast differentiation  fibronectin binding  protein binding  extracellular region  extracellular region  intracellular  glucose metabolic process  signal transduction  female pregnancy  aging  regulation of glucose metabolic process  negative regulation of smooth muscle cell migration  insulin-like growth factor binding protein complex  negative regulation of translation  negative regulation of cell migration  hair follicle morphogenesis  insulin-like growth factor I binding  insulin-like growth factor II binding  intracellular signal transduction  insulin-like growth factor ternary complex  glucose homeostasis  positive regulation of insulin-like growth factor receptor signaling pathway  negative regulation of insulin-like growth factor receptor signaling pathway  cellular protein metabolic process  type B pancreatic cell proliferation  negative regulation of osteoblast differentiation  negative regulation of growth  lung alveolus development  negative regulation of smooth muscle cell proliferation  striated muscle cell differentiation  positive regulation of protein kinase B signaling  mammary gland involution  response to growth hormone  cellular response to cAMP  cellular response to organic cyclic compound  negative regulation of muscle tissue development  negative regulation of skeletal muscle hypertrophy  
Pathways : BIOCARTAGhrelin: Regulation of Food Intake and Energy Homeostasis [Genes]   
NDEx NetworkIGFBP5
Atlas of Cancer Signalling NetworkIGFBP5
Wikipedia pathwaysIGFBP5
Orthology - Evolution
OrthoDB3488
GeneTree (enSembl)ENSG00000115461
Phylogenetic Trees/Animal Genes : TreeFamIGFBP5
HOVERGENP24593
HOGENOMP24593
Homologs : HomoloGeneIGFBP5
Homology/Alignments : Family Browser (UCSC)IGFBP5
Gene fusions - Rearrangements
Fusion : MitelmanEZH1/IGFBP5 [17q21.2/2q35]  [t(2;17)(q35;q21)]  
Fusion : MitelmanIGFBP5/ARHGEF4 [2q35/2q21.1]  [t(2;2)(q21;q35)]  
Fusion : MitelmanIGFBP5/CXCR5 [2q35/11q23.3]  [t(2;11)(q35;q23)]  
Fusion : MitelmanIGFBP5/SIAE [2q35/11q24.2]  [t(2;11)(q35;q24)]  
Fusion: TCGAEZH1 17q21.2 IGFBP5 2q35 PRAD
Fusion: TCGAIGFBP5 2q35 ARHGEF4 2q21.1 THCA
Fusion: TCGAIGFBP5 2q35 CXCR5 11q23.3 BRCA
Fusion: TCGAIGFBP5 2q35 SIAE 11q24.2 THCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIGFBP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IGFBP5
dbVarIGFBP5
ClinVarIGFBP5
1000_GenomesIGFBP5 
Exome Variant ServerIGFBP5
ExAC (Exome Aggregation Consortium)IGFBP5 (select the gene name)
Genetic variants : HAPMAP3488
Genomic Variants (DGV)IGFBP5 [DGVbeta]
DECIPHERIGFBP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIGFBP5 
Mutations
ICGC Data PortalIGFBP5 
TCGA Data PortalIGFBP5 
Broad Tumor PortalIGFBP5
OASIS PortalIGFBP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIGFBP5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIGFBP5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IGFBP5
DgiDB (Drug Gene Interaction Database)IGFBP5
DoCM (Curated mutations)IGFBP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IGFBP5 (select a term)
intoGenIGFBP5
Cancer3DIGFBP5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146734   
Orphanet
MedgenIGFBP5
Genetic Testing Registry IGFBP5
NextProtP24593 [Medical]
TSGene3488
GENETestsIGFBP5
Huge Navigator IGFBP5 [HugePedia]
snp3D : Map Gene to Disease3488
BioCentury BCIQIGFBP5
ClinGenIGFBP5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3488
Chemical/Pharm GKB GenePA29707
Clinical trialIGFBP5
Miscellaneous
canSAR (ICR)IGFBP5 (select the gene name)
Probes
Litterature
PubMed150 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIGFBP5
EVEXIGFBP5
GoPubMedIGFBP5
iHOPIGFBP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:20:06 CEST 2017

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