IGFBP5 (insulin like growth factor binding protein 5)

2007-02-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
IBP5
FUSION GENES

Other Information

Locus ID:

NCBI: 3488
MIM: 146734
HGNC: 5474
Ensembl: ENSG00000115461

Variants:

dbSNP: 3488
ClinVar: 3488
TCGA: ENSG00000115461
COSMIC: IGFBP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115461ENST00000233813P24593
ENSG00000115461ENST00000233813A0A024R433
ENSG00000115461ENST00000449583C9JXX4

Expression (GTEx)

0
500
1000
1500
2000
2500
3000

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426

References

Pubmed IDYearTitleCitations
156818242005Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition.82
199480512009Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes.74
178048192007Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
214608552011Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma.61
127773772003Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo.50
252480362014Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.50
199502262010Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.45
187625762008IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop.40
256030502015MiR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma.40

Citation

Dessen P

IGFBP5 (insulin like growth factor binding protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45717/igfbp5